{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:30:52Z","timestamp":1780421452587,"version":"3.54.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"US National Institute of Health","award":["RO1CA159868"],"award-info":[{"award-number":["RO1CA159868"]}]},{"name":"Australian Breast Cancer Family Registry"},{"name":"ABCFR"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New South Wales Cancer Council"},{"DOI":"10.13039\/100007220","name":"Victorian Health Promotion Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007220","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Victorian Breast Cancer Research Consortium"},{"DOI":"10.13039\/501100001026","name":"National Breast Cancer Foundation","doi-asserted-by":"publisher","award":["UM1 CA164920"],"award-info":[{"award-number":["UM1 CA164920"]}],"id":[{"id":"10.13039\/501100001026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"US National Cancer Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The performance of breast cancer risk models for women with a family history but negative BRCA1 and\/or BRCA2 mutation test results is uncertain. We calculated the cumulative 10-year invasive breast cancer risk at cohort entry for 14 657 unaffected women (96.1% had an affected relative) not known to carry BRCA1 or BRCA2 mutations at baseline using three pedigree-based models (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm, BRCAPRO, and International Breast Cancer Intervention Study). During follow-up, 482 women were diagnosed with invasive breast cancer. Mutation testing was conducted independent of incident cancers. All models underpredicted risk by 26.3%\u201356.7% for women who tested negative but whose relatives had not been tested (n\u2009=\u20091363; 63 breast cancers). Although replication studies with larger sample sizes are needed, until these models are recalibrated for women who test negative and have no relatives tested, caution should be used when considering changing the breast cancer risk management intensity of such women based on risk estimates from these models.<\/jats:p>","DOI":"10.1093\/jnci\/djz194","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T03:55:43Z","timestamp":1569902143000},"page":"418-422","source":"Crossref","is-referenced-by-count":1,"title":["Considerations When Using Breast Cancer Risk Models for Women with Negative BRCA1\/BRCA2 Mutation Results"],"prefix":"10.1093","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-5047","authenticated-orcid":false,"given":"Robert J","family":"MacInnis","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population & Global Health, The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A","family":"Knight","sequence":"first","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-7268","authenticated-orcid":false,"given":"Roger L","family":"Milne","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population & Global Health, The University of Melbourne, Parkville, Victoria, Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S","family":"Whittemore","sequence":"first","affiliation":[{"name":"Departments of Health Research and Policy and Biomedical Data Science, Stanford University School of Medicine, Stanford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K","family":"Chung","sequence":"first","affiliation":[{"name":"Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York"},{"name":"Departments of Pediatrics and Medicine, Columbia University, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Leoce","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public 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C","family":"Southey","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"},{"name":"Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldgar","sequence":"first","affiliation":[{"name":"Department of Medicine and Huntsman Cancer Institute, University of Utah Health, Salt Lake City, UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham G","family":"Giles","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia"},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population & Global Health, The University of Melbourne, Parkville, Victoria, Australia"},{"name":"Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue-Anne","family":"McLachlan","sequence":"first","affiliation":[{"name":"Department of Medicine, St Vincent\u2019s Hospital, The University of Melbourne, Parkville, Victoria, Australia"},{"name":"Department of Medical Oncology, St Vincent\u2019s Hospital, Fitzroy, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3672-5201","authenticated-orcid":false,"given":"Prue C","family":"Weideman","sequence":"first","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population & Global Health, The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Nesci","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L","family":"Friedlander","sequence":"first","affiliation":[{"name":"Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia"},{"name":"Department of Medical Oncology, Prince of Wales Hospital, Randwick, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gord","family":"Glendon","sequence":"first","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"kConFab Investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene L","family":"Andrulis","sequence":"first","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada"},{"name":"Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"The Research Department, The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"},{"name":"Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3259-8003","authenticated-orcid":false,"given":"Esther M","family":"John","sequence":"first","affiliation":[{"name":"Department of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B","family":"Daly","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics, Fox Chase Cancer 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