{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:16:16Z","timestamp":1791688576753,"version":"4.3.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01CA154292 (to K.K.)"],"award-info":[{"award-number":["P01CA154292 (to K.K.)"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA166269 (to J.J.H.)"],"award-info":[{"award-number":["R01CA166269 (to J.J.H.)"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA207804 (to C.M.V.)"],"award-info":[{"award-number":["R01CA207804 (to C.M.V.)"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA177150 (to K.K. and C.M.V.)"],"award-info":[{"award-number":["R01CA177150 (to K.K. and C.M.V.)"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High alcohol intake and breast density increase breast cancer (BC) risk, but their interrelationship is unknown. We examined whether volumetric density modifies and\/or mediates the alcohol-BC association. BC cases (n\u2009=\u20092233) diagnosed from 2006 to 2013 in the San Francisco Bay area had screening mammograms 6\u2009or more months before diagnosis; controls (n\u2009=\u20094562) were matched on age, mammogram date, race or ethnicity, facility, and mammography machine. Logistic regression was used to estimate alcohol-BC associations adjusted for age, body mass index, and menopause; interaction terms assessed modification. Percent mediation was quantified as the ratio of log (odds ratios [ORs]) from models with and without density measures. Alcohol consumption was associated with increased BC risk (2-sided Ptrend\u2009=\u2009.004), as were volumetric percent density (OR\u2009=\u20091.45 per SD, 95% confidence interval [CI]\u2009=\u20091.36 to 1.56) and dense volume (OR\u2009=\u20091.30, 95% CI\u2009=\u20091.24 to 1.37). Breast density did not modify the alcohol-BC association (2-sided P\u2009&amp;gt;\u2009.10 for all). Dense volume mediated 25.0% (95% CI\u2009=\u20095.5% to 44.4%) of the alcohol-BC association (2-sided P\u2009=\u2009.01), suggesting alcohol may partially increase BC risk by increasing fibroglandular tissue.<\/jats:p>","DOI":"10.1093\/jncics\/pkaa124","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T12:06:48Z","timestamp":1609675608000},"source":"Crossref","is-referenced-by-count":5,"title":["Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-7658","authenticated-orcid":false,"given":"Alison S","family":"Rustagi","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California at San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-0647","authenticated-orcid":false,"given":"Christopher G","family":"Scott","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey J","family":"Winham","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-2708","authenticated-orcid":false,"given":"Aaron D","family":"Norman","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"Jensen","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Hawaii, Honolulu, HI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Hruska","sequence":"additional","affiliation":[{"name":"Division of Medical Physics, Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Heine","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Department, MCC, Moffitt Cancer Center & Research Institute, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon S","family":"Pankratz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Biochemistry, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Kerlikowske","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs, University of California at San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine M","family":"Vachon","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 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