{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:58:48Z","timestamp":1761562728591,"version":"3.41.2"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"publisher","award":["No. 70112095 and 70113330"],"award-info":[{"award-number":["No. 70112095 and 70113330"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Federal Ministry of Education and Research","award":["No. 01GL1712"],"award-info":[{"award-number":["No. 01GL1712"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Polygenic risk scores (PRS), which are derived from results of large genome-wide association studies, are increasingly propagated for colorectal cancer (CRC) risk stratification. The majority of studies included in the large genome-wide association studies consortia were conducted in the United States and Germany, where colonoscopy with detection and removal of polyps has been widely practiced over the last decades. We aimed to assess if and to what extent the history of colonoscopy with polypectomy may alter metrics of the predictive ability of PRS for CRC risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A PRS based on 140 single nucleotide polymorphisms was compared between 4939\u00a0CRC patients and 3797\u00a0control persons of the Darmkrebs: Chancen der Verh\u00fctung durch Screening (DACHS) study, a population-based case-control study conducted in Germany. Risk discrimination was quantified according to the history of colonoscopy and polypectomy by areas under the curves (AUCs) and their 95% confidence intervals (CIs). All statistical tests were 2-sided.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>AUCs and 95% CIs were higher among subjects without previous colonoscopy (AUC = 0.622, 95% CI = 0.606 to 0.639) than among those with previous colonoscopy and polypectomy (AUC = 0.568, 95% CI = 0.536 to 0.601; difference [\u0394 AUC] = 0.054, P\u2009=\u2009.004). Such differences were consistently seen in sex-specific groups (women: \u0394 AUC = 0.073, P\u2009=\u2009.02; men: \u0394 AUC = 0.046, P\u2009=\u2009.048) and age-specific groups (younger than 70\u2009years: \u0394 AUC = 0.052, P\u2009=\u2009.07; 70\u2009years or older: \u0394 AUC = 0.049, P\u2009=\u2009.045).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Predictive performance of PRS may be underestimated in populations with widespread use of colonoscopy. Future studies using PRS to develop CRC prediction models should carefully consider colonoscopy history to provide more accurate estimates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkab008","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T05:19:43Z","timestamp":1610515183000},"source":"Crossref","is-referenced-by-count":3,"title":["Colorectal Cancer Risk by Genetic Variants in Populations With and Without Colonoscopy History"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5026-7024","authenticated-orcid":false,"given":"Feng","family":"Guo","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, 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