{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:25Z","timestamp":1753877185330,"version":"3.41.2"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"USA National Cancer Institute","award":["U01 CA164920"],"award-info":[{"award-number":["U01 CA164920"]}]},{"name":"kConFab and the kConFab Follow-Up Study from Cancer Australia","award":["809195, 1100868"],"award-info":[{"award-number":["809195, 1100868"]}]},{"DOI":"10.13039\/501100001026","name":"Australian National Breast Cancer Foundation","doi-asserted-by":"crossref","award":["IF 17 kConFab"],"award-info":[{"award-number":["IF 17 kConFab"]}],"id":[{"id":"10.13039\/501100001026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["454508, 288704, 145684"],"award-info":[{"award-number":["454508, 288704, 145684"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health USA","award":["1R01CA159868"],"award-info":[{"award-number":["1R01CA159868"]}]},{"name":"Queensland Cancer Fund"},{"name":"Cancer Councils of New South Wales, Victoria, Tasmania and South Australia"},{"DOI":"10.13039\/501100001170","name":"Cancer Foundation of Western Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"crossref"}]},{"name":"KAP is a National Health and Medical Research Council Leadership Fellow","award":["1195294"],"award-info":[{"award-number":["1195294"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Recreational physical activity (RPA) is associated with improved survival after breast cancer (BC) in average-risk women, but evidence is limited for women who are at increased familial risk because of a BC family history or BRCA1 and BRCA2 pathogenic variants (BRCA1\/2 PVs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We estimated associations of RPA (self-reported average hours per week within 3 years of BC diagnosis) with all-cause mortality and second BC events (recurrence or new primary) after first invasive BC in women in the Prospective Family Study Cohort (n = 4610, diagnosed 1993-2011, aged 22-79 years at diagnosis). We fitted Cox proportional hazards regression models adjusted for age at diagnosis, demographics, and lifestyle factors. We tested for multiplicative interactions (Wald test statistic for cross-product terms) and additive interactions (relative excess risk due to interaction) by age at diagnosis, body mass index, estrogen receptor status, stage at diagnosis, BRCA1\/2 PVs, and familial risk score estimated from multigenerational pedigree data. Statistical tests were 2-sided.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We observed 1212 deaths and 473 second BC events over a median follow-up from study enrollment of 11.0 and 10.5 years, respectively. After adjusting for covariates, RPA (any vs none) was associated with lower all-cause mortality of 16.1% (95% confidence interval [CI] = 2.4% to 27.9%) overall, 11.8% (95% CI = -3.6% to 24.9%) in women without BRCA1\/2 PVs, and 47.5% (95% CI = 17.4% to 66.6%) in women with BRCA1\/2 PVs (RPA*BRCA1\/2 multiplicative interaction P = .005; relative excess risk due to interaction = 0.87, 95% CI = 0.01 to 1.74). RPA was not associated with risk of second BC events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Findings support that RPA is associated with lower all-cause mortality in women with BC, particularly in women with BRCA1\/2 PVs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkab090","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T04:17:29Z","timestamp":1638332249000},"source":"Crossref","is-referenced-by-count":4,"title":["Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6089-6799","authenticated-orcid":false,"given":"Rebecca D","family":"Kehm","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-5047","authenticated-orcid":false,"given":"Robert J","family":"MacInnis","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3259-8003","authenticated-orcid":false,"given":"Esther M","family":"John","sequence":"additional","affiliation":[{"name":"Department of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-9470","authenticated-orcid":false,"given":"Allison W","family":"Kurian","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-0412","authenticated-orcid":false,"given":"Jeanine M","family":"Genkinger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA"},{"name":"Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia A","family":"Knight","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada"},{"name":"Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-6990","authenticated-orcid":false,"given":"Sarah V","family":"Colonna","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Huntsman Cancer Institute, Salt Lake City, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-5685","authenticated-orcid":false,"given":"Wendy K","family":"Chung","sequence":"additional","affiliation":[{"name":"Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA"},{"name":"Departments of Pediatrics and Medicine, Columbia University Medical Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-7268","authenticated-orcid":false,"given":"Roger","family":"Milne","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-8599","authenticated-orcid":false,"given":"Nur","family":"Zeinomar","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2448-2548","authenticated-orcid":false,"given":"Gillian S","family":"Dite","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-9005","authenticated-orcid":false,"given":"Melissa C","family":"Southey","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"},{"name":"Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4946-9099","authenticated-orcid":false,"given":"Graham G","family":"Giles","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia"},{"name":"Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-0322","authenticated-orcid":false,"given":"Sue-Anne","family":"McLachlan","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent\u2019s Hospital, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Department of Medical Oncology, St Vincent\u2019s Hospital, Fitzroy, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-3838","authenticated-orcid":false,"given":"Kristen D","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3090-795X","authenticated-orcid":false,"given":"Michael L","family":"Friedlander","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia"},{"name":"Department of Medical Oncology, Prince of Wales Hospital, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prue C","family":"Weideman","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8630-6673","authenticated-orcid":false,"given":"Gord","family":"Glendon","sequence":"additional","affiliation":[{"name":"Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Nesci","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"kConFab Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0475-1771","authenticated-orcid":false,"given":"Kelly-Anne","family":"Phillips","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and 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S","family":"Buys","sequence":"additional","affiliation":[{"name":"Department of Medicine and Huntsman Cancer Institute, University of Utah Health, Salt Lake City, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary B","family":"Daly","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-173X","authenticated-orcid":false,"given":"John L","family":"Hopper","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-5033","authenticated-orcid":false,"given":"Mary Beth","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of 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