{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T02:39:38Z","timestamp":1762051178104,"version":"build-2065373602"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>It is unknown how body fat distribution modulates the cardiometabolic risk of testicular cancer survivors after cisplatin-based chemotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>For 455 patients enrolled in the Platinum Study at Memorial Sloan Kettering Cancer Center, visceral (VAT) and subcutaneous (SAT) adipose tissue was quantified on prechemotherapy computed tomography. The VAT-to-SAT ratio was calculated as a quantitative measure of central adiposity. Endpoints were incidence of new posthemotherapy cardiometabolic disease (new antihypertensive, lipid-lowering, or diabetes medication), and postchemotherapy Framingham risk scores. Cox models and linear regression with interaction terms were applied. Postchemotherapy body fat distribution was analyzed in 108 patients. All statistical tests were 2-sided.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The baseline median age was 31\u2009years (interquartile range [IQR]\u2009=\u200926-39 years), body mass index (BMI) was 26\u2009kg\/m2 (IQR = 24-29 kg\/m2), and the\u00a0VAT-to-SAT ratio was 0.49 (IQR = 0.31-0.75). The median follow-up was 26\u2009months (IQR = 16-59 months). Higher prechemotherapy\u00a0VAT-to-SAT ratios inferred a higher likelihood of new cardiometabolic disease among patients with a BMI of 30\u2009kg\/m2 or greater (age-adjusted hazard ratio\u2009=\u20093.14, 95% confidence interval\u2009=\u20091.02 to 9.71, P\u2009=\u2009.047), but not other BMI groups. The prechemotherapy\u00a0VAT-to-SAT ratio was associated with postchemotherapy Framingham risk scores in univariate regression analysis (exp(\u03b2)-estimate: 2.10, 95% confidence interval = 1.84 to 2.39, P\u2009&amp;lt;\u2009.001); in a multivariable model, this association was stronger in younger vs older individuals. BMI increased in most patients after chemotherapy and correlated with increases in the\u00a0VAT-to-SAT ratio (Spearman r\u2009=\u20090.39, P\u2009&amp;lt;\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In testicular cancer survivors, central adiposity is associated with increased cardiometabolic risk after cisplatin-based chemotherapy, particularly in obese or young men. Weight gain after chemotherapy occurs preferentially in the visceral compartment, providing insight into the pathogenesis of cardiovascular disease in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkac030","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T19:18:21Z","timestamp":1652210301000},"source":"Crossref","is-referenced-by-count":8,"title":["Associations of Body Fat Distribution and Cardiometabolic Risk of Testicular Cancer Survivors After Cisplatin-Based Chemotherapy"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-6706","authenticated-orcid":false,"given":"Andreas G","family":"Wibmer","sequence":"first","affiliation":[{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center , New York, NY, 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D","family":"Sesso","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital , Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2424-4635","authenticated-orcid":false,"given":"Darren R","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Genitourinary Service, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-133X","authenticated-orcid":false,"given":"Hebert Alberto","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center , New York, NY, 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