{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:14Z","timestamp":1753877174502,"version":"3.41.2"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA233524","P01CA206980","R01CA112243","U01CA83180","R01CA112524","R01CA098438","R03CA125829","R03CA173806","P30CA016086"],"award-info":[{"award-number":["R01CA233524","P01CA206980","R01CA112243","U01CA83180","R01CA112524","R01CA098438","R03CA125829","R03CA173806","P30CA016086"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES010126"],"award-info":[{"award-number":["P30ES010126"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of North Carolina Center for Environmental Health and Susceptibility"},{"name":"NHMCR Career Development Fellowship"},{"name":"NHMCR Early Career Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>It is unclear whether genetic variants affecting vitamin D metabolism are associated with melanoma prognosis. Two functional missense variants in the vitamin D\u2013binding protein gene (GC), rs7041 and rs4588, determine 3 common haplotypes, Gc1s, Gc1f, and Gc2, of which Gc1f may be associated with decreased all-cause death among melanoma patients based on results of a prior study, but the association of Gc1f with melanoma-specific death is unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We investigated the association of the Gc1s, Gc1f, and Gc2 haplotypes with melanoma-specific and all-cause death among 4490 individuals with incident, invasive primary melanoma in 2 population-based studies using multivariable Cox-proportional hazards regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the pooled analysis of both datasets, the patients with the Gc1f haplotype had a 37% lower risk of melanoma-specific death than the patients without Gc1f (hazard ratio [HR] = 0.63, 95% confidence interval [CI] = 0.47 to 0.83, P\u2009=\u2009.001), with adjustments for age, sex, study center, first- or higher-order primary melanoma, tumor site, pigmentary phenotypes, and Breslow thickness. Associations were similar in both studies. In pooled analyses stratified by Breslow thickness, the corresponding melanoma-specific death HRs for those patients with the Gc1f haplotype compared with those without Gc1f were 0.89 (95% CI\u2009=\u20090.63 to 1.27) among participants with tumor Breslow thickness equal to or less than 2.0\u2009mm and 0.40 (95% CI\u2009=\u20090.25 to 0.63) among participants with tumor Breslow thickness greater than 2.0\u2009mm (Pinteraction\u2009=\u2009.003).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings suggest that individuals with the GC haplotype Gc1f may have a lower risk of dying from melanoma\u2014specifically from thicker, higher-risk melanoma\u2014than individuals without this Gc1f haplotype.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkad051","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T12:22:41Z","timestamp":1690287761000},"source":"Crossref","is-referenced-by-count":2,"title":["Association of functional, inherited vitamin D\u2013binding protein variants with melanoma-specific death"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-6272","authenticated-orcid":false,"given":"David Corley","family":"Gibbs","sequence":"first","affiliation":[{"name":"Department of Dermatology, Emory University , Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy E","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of North Carolina , Chapel Hill, NC, USA"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-9618","authenticated-orcid":false,"given":"Peter A","family":"Kanetsky","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute , Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico , Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus J","family":"Busam","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E","family":"Cust","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, The University of Sydney , Sydney, NSW, Australia"},{"name":"The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW , Sydney, NSW, Australia"},{"name":"Melanoma Institute Australia, The University of Sydney , Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-0110","authenticated-orcid":false,"given":"Hoda","family":"Anton-Culver","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of California , Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Cancer Control Research, British Columbia Cancer and Department of Dermatology and Skin Science, University of British Columbia , Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Zanetti","sequence":"additional","affiliation":[{"name":"Center for Cancer Prevention, Piedmont Cancer Registry , Torino, Italy"},{"name":"Fondo Elena Moroni for Oncology , Torino, Italy"},{"name":"Department of Surgery, University of North Carolina , Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Rosso","sequence":"additional","affiliation":[{"name":"Center for Cancer Prevention, Piedmont Cancer Registry , Torino, Italy"},{"name":"Fondo Elena Moroni for Oncology , Torino, Italy"},{"name":"Department of Surgery, University of North Carolina , Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Sacchetto","sequence":"additional","affiliation":[{"name":"Center for Cancer Prevention, Piedmont Cancer Registry , Torino, Italy"},{"name":"Fondo Elena Moroni for Oncology , Torino, Italy"},{"name":"Department of Surgery, University of North Carolina , Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon N","family":"Edmiston","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Conway","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC, USA"},{"name":"Department of Epidemiology, Gillings Global School of Public Health, University of North Carolina , Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W","family":"Ollila","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC, USA"},{"name":"Department of Surgery, University of North Carolina , Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin B","family":"Begg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, NY, 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