{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:09:58Z","timestamp":1790014198715,"version":"4.0.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GERCOR"},{"name":"Programme Hospitalier de Recherche Clinique 2009"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Small bowel adenocarcinoma is a rare cancer, and the role of adjuvant chemotherapy for localized disease is still debated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective multicenter study included all consecutive patients who underwent curative surgical resection for localized small bowel adenocarcinoma between 1996 and 2019 from 3 French cohort studies. Prognostic and predictive factors of adjuvant chemotherapy efficacy were analyzed for disease-free survival and overall survival. The inverse probability of treatment weighting method was applied in the Cox regression model using the propensity score derived from multivariable logistic regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 354 patients were included: median age, 63.5 years; duodenum location, 53.5%; and tumor stage I, II, and III in 31 (8.7%), 144 (40.7%), and 179 (50.6%) patients, respectively. The adjuvant chemotherapy was administered in 0 (0%), 66 (48.5%), and 143 (80.3%) patients with stage I, II, and III, respectively (P\u2009&amp;lt;\u2009.0001). In the subgroup analysis by inverse probability of treatment weighting method, a statistically significant disease-free survival and overall survival benefit in favor of adjuvant chemotherapy was observed in high-risk stage II (T4 and\/or &amp;lt;8 lymph nodes examined) and III (T4 and\/or N2) but not for low-risk stage II (T3 and \u22658 lymph nodes examined) and III (T1-3\/N1) tumors (Pinteraction &amp;lt; .05). Furthermore, tumor location in jejunum and ileum was also a statistically significant predictive factor of response to adjuvant chemotherapy in stage II and III tumors (Pinteraction &amp;lt; .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In localized small bowel adenocarcinoma, adjuvant chemotherapy seems to provide a statistically significant survival benefit for high-risk stage II and III tumors and for jejunum and ileum tumor locations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkad064","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T17:48:47Z","timestamp":1696009727000},"source":"Crossref","is-referenced-by-count":10,"title":["Adjuvant chemotherapy benefit according to T and N stage in small bowel adenocarcinoma: a large retrospective multicenter study"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-5653","authenticated-orcid":false,"given":"Aziz","family":"Zaanan","sequence":"first","affiliation":[{"name":"Department of Digestive Oncology, European Georges Pompidou Hospital, Assistance Publique-H\u00f4pitaux de Paris (APHP), Universit\u00e9 Paris Cit\u00e9, Paris Cancer Institute CARPEM , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Henriques","sequence":"additional","affiliation":[{"name":"Methodology and Quality of Life Unit in Oncology, centre hospitalier universitaire (CHU) Besan\u00e7on, H\u00f4pital Jean Minjoz , Besan\u00e7on, France"},{"name":"Bourgogne Franche-Comt\u00e9 University, INSERM, Etablissement Fran\u00e7ais du Sang Bourgogne Franche-Comt\u00e9, UMR1098, Interactions H\u00f4te-Greffon-Tumeur\/Ing\u00e9nierie Cellulaire et G\u00e9nique , Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Turpin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, centre hospitalier universitaire (CHU) Lille\u2014H\u00f4pital Claude Huriez , Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology and Digestive Oncology, Dijon University Hospital, EPICAD LNC UMR 1231, University of Burgundy , Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Coriat","sequence":"additional","affiliation":[{"name":"Gastroenterology and Oncology Department, H\u00f4pital Cochin AP-HP, Universit\u00e9 Paris Cit\u00e9 , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Terrebonne","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, CIC 1401, centre hospitalier universitaire (CHU) Haut L\u00e9v\u00e8que , Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Legoux","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology and Digestive Oncology, Centre Hospitalier R\u00e9gional d\u2019Orl\u00e9ans , Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospices Civils de Lyon , Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Locher","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Oncology Department, Meaux Hospital , Meaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dubreuil","sequence":"additional","affiliation":[{"name":"Department of Digestive Oncology, Groupe hospitalier Diaconesses Croix Saint Simon , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Pernot","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Institut Bergoni\u00e9 , Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Vernet","sequence":"additional","affiliation":[{"name":"Department of Digestive Oncology, H\u00f4pital Priv\u00e9 Jean Mermoz , Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bouch\u00e9","sequence":"additional","affiliation":[{"name":"Department of Digestive Oncology and Gastroenterology, University of Reims Champagne-Ardenne (URCA), centre hospitalier universitaire (CHU) Reims , Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Hautefeuille","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology and Digestive Oncology, Amiens University Hospital , Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Gagniere","sequence":"additional","affiliation":[{"name":"Department of Digestive and Hepatobiliary Surgery, University Hospital of Clermont-Ferrand, U1071 INSERM, Clermont-Auvergne University , Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lecomte","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology and Digestive Oncology, University Hospital of Tours, Tours University, U1069 INSERM \u201cNutrition, Croissance et Cancer\u201d , Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tougeron","sequence":"additional","affiliation":[{"name":"Department of Hepato-Gastroenterology, centre hospitalier universitaire (CHU) de Poitiers , Poitiers, 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