{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:33:51Z","timestamp":1775151231454,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["NSTC112-2321-B-038-005"],"award-info":[{"award-number":["NSTC112-2321-B-038-005"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent studies propose fallopian tubes as the tissue origin for many ovarian epithelial cancers. To further support this paradigm, we assessed whether salpingectomy for treating ectopic pregnancy had a protective effect using the Taiwan Longitudinal National Health Research Database. We identified 316\u200a882 women with surgical treatment for ectopic pregnancy and 3\u200a168\u200a820 age- and index-date-matched controls from 2000 to 2016. In a nested cohort, 91.5% of cases underwent unilateral salpingectomy, suggesting that most surgically managed patients have salpingectomy. Over a follow-up period of 17\u2009years, the ovarian carcinoma incidence was 0.0069 (95% confidence interval [CI] = 0.0060 to 0.0079) and 0.0089 (95% CI = 0.0086 to 0.0092) in the ectopic pregnancy and the control groups, respectively (P\u2009&amp;lt;\u2009.001). After adjusting the events to per 100 person-years, the hazard ratio (HR) in the ectopic pregnancy group was 0.70 (95% CI = 0.61 to 0.80). The risk reduction occurred only in epithelial ovarian cancer (HR = 0.73, 95% CI = 0.63 to 0.86) and not in non-epithelial subtypes. These findings show a decrease in ovarian carcinoma incidence after salpingectomy for treating ectopic pregnancy.<\/jats:p>","DOI":"10.1093\/jncics\/pkae027","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T21:19:00Z","timestamp":1712611140000},"source":"Crossref","is-referenced-by-count":7,"title":["Salpingectomy for ectopic pregnancy reduces ovarian cancer risk\u2014a nationwide study"],"prefix":"10.1093","volume":"8","author":[{"given":"Ju-Chuan","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Taipei Ren-Ai Branch, and Department of Education and Research, Taipei City Hospital , Taipei, Taiwan"},{"name":"Graduate Institute of Biomedical Informatics, Taipei Medical University , Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-I","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wan Fang Hospital, Taipei Medical University, Cancer Center, Wan Fang Hospital, Taipei Medical University , Taipei, Taiwan"},{"name":"Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University , Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine , Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine , Baltimore, MD, USA"},{"name":"Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions , Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kala","family":"Visvanathan","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions , Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Data Science, Taipei Medical University , Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Huei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Data Science, Taipei Medical University , Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1084-2071","authenticated-orcid":false,"given":"Ie-Ming","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine , Baltimore, MD, USA"},{"name":"Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions , Baltimore, MD, 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