{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:29:47Z","timestamp":1777498187271,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA226060"],"award-info":[{"award-number":["R01CA226060"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189974"],"award-info":[{"award-number":["UG1CA189974"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA190002"],"award-info":[{"award-number":["UG1CA190002"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189830"],"award-info":[{"award-number":["UG1CA189830"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189858"],"award-info":[{"award-number":["UG1CA189858"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189953"],"award-info":[{"award-number":["UG1CA189953"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189960"],"award-info":[{"award-number":["UG1CA189960"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180858"],"award-info":[{"award-number":["U10CA180858"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180828"],"award-info":[{"award-number":["U10CA180828"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180819"],"award-info":[{"award-number":["U10CA180819"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Deep learning\u2013based mammographic evaluations could noninvasively assess response to breast cancer chemoprevention. We evaluated change in a convolutional neural network\u2013based breast cancer risk model applied to mammograms among women enrolled in SWOG S0812, which randomly assigned 208 premenopausal high-risk women to receive oral vitamin D3 20\u200a000\u2009IU weekly or placebo for 12\u2009months. We applied the convolutional neural network model to mammograms collected at baseline (n\u2009=\u2009109), 12\u2009months (n\u2009=\u200997), and 24\u2009months (n\u2009=\u200967) and compared changes in convolutional neural network-based risk score between treatment groups. Change in convolutional neural network-based risk score was not statistically significantly different between vitamin D and placebo groups at 12\u2009months (0.005 vs 0.002, P\u2009=\u2009.875) or at 24\u2009months (0.020 vs 0.001, P\u2009=\u2009.563). The findings are consistent with the primary analysis of S0812, which did not demonstrate statistically significant changes in mammographic density with vitamin D supplementation compared with placebo. There is an ongoing need to evaluate biomarkers of response to novel breast cancer chemopreventive agents.<\/jats:p>","DOI":"10.1093\/jncics\/pkae042","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T20:39:29Z","timestamp":1717101569000},"source":"Crossref","is-referenced-by-count":4,"title":["Effects of vitamin D supplementation on a deep learning\u2013based mammographic evaluation in SWOG S0812"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5292-1440","authenticated-orcid":false,"given":"Julia E","family":"McGuinness","sequence":"first","affiliation":[{"name":"Department of Medicine, Columbia University Irving Medical Center and the Herbert Irving Comprehensive Cancer Center , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garnet L","family":"Anderson","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, WA, USA"},{"name":"SWOG Cancer Research Network, Statistics and Data Management Center , Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simukayi","family":"Mutasa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lenox Hill Hospital , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn L","family":"Hershman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Irving Medical Center and the Herbert Irving Comprehensive Cancer Center , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Irving Medical Center and the Herbert Irving Comprehensive Cancer Center , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Tehranifar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Irving Medical Center and the Herbert Irving Comprehensive Cancer Center , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danika L","family":"Lew","sequence":"additional","affiliation":[{"name":"SWOG Cancer Research Network, Statistics and Data Management Center , Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Yee","sequence":"additional","affiliation":[{"name":"SWOG Cancer Research Network, Statistics and Data Management Center , Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A","family":"Brown","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Beaumont National Cancer Institute Community Oncology Research Program , Troy, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien S","family":"Kairouz","sequence":"additional","affiliation":[{"name":"Cancer Care Specialists of Central Illinois, Heartland National Cancer Institute Community Oncology Research Program , Decatur, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafisa","family":"Kuwajerwala","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Beaumont National Cancer Institute Community Oncology Research Program , Troy, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese B","family":"Bevers","sequence":"additional","affiliation":[{"name":"Department of Clinical Cancer Prevention, MD Anderson Cancer Center , Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E","family":"Doster","sequence":"additional","affiliation":[{"name":"Anderson Area Cancer Center, Southeast Clinical Oncology Research Consortium National Cancer Institute Community Oncology Research Program , Anderson, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrine","family":"Zarwan","sequence":"additional","affiliation":[{"name":"Lahey Hospital and Medical Center , Burlington, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Kruper","sequence":"additional","affiliation":[{"name":"Department of Breast Oncology, City of Hope Medical Center , Duarte, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-4079","authenticated-orcid":false,"given":"Lori M","family":"Minasian","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention, National Cancer Institute , Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Ford","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention, National Cancer Institute , Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Arun","sequence":"additional","affiliation":[{"name":"Department of Clinical Cancer Prevention, MD Anderson Cancer Center , Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-0000","authenticated-orcid":false,"given":"Marian L","family":"Neuhouser","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary E","family":"Goodman","sequence":"additional","affiliation":[{"name":"Swedish Cancer Institute, Pacific Cancer Research Consortium National Cancer Institute Community Oncology Research Program , Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Powel H","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Clinical Cancer Prevention, MD Anderson Cancer Center , Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Irving Medical Center and the Herbert Irving Comprehensive Cancer Center , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine D","family":"Crew","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Irving Medical Center and the Herbert Irving Comprehensive Cancer Center , New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"2024070121173110000_pkae042-B1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-3-540-69297-3_12","article-title":"The use of tamoxifen and raloxifene for the prevention of breast cancer","volume":"181","author":"Wickerham","year":"2009","journal-title":"Recent Results Cancer Res"},{"issue":"1","key":"2024070121173110000_pkae042-B2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/s1470-2045(14)71171-4","article-title":"Tamoxifen for prevention of breast cancer: Extended long-term follow-up of the IBIS-I breast cancer prevention trial","volume":"16","author":"Cuzick","year":"2015","journal-title":"Lancet Oncol"},{"issue":"6","key":"2024070121173110000_pkae042-B3","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1158\/1940-6207.Capr-10-0076","article-title":"Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing breast cancer","volume":"3","author":"Vogel","year":"2010","journal-title":"Cancer Prev Res (Phila)"},{"issue":"25","key":"2024070121173110000_pkae042-B4","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1056\/NEJMoa1103507","article-title":"Exemestane for breast-cancer prevention in postmenopausal women","volume":"364","author":"Goss","year":"2011","journal-title":"New Engl J Med"},{"issue":"9922","key":"2024070121173110000_pkae042-B5","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/s0140-6736(13)62292-8","article-title":"Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial","volume":"383","author":"Cuzick","year":"2014","journal-title":"Lancet"},{"issue":"12","key":"2024070121173110000_pkae042-B6","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1200\/jco.2010.34.0141","article-title":"Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor\u2013positive ductal carcinoma in situ: a study based on NSABP protocol B-24","volume":"30","author":"Allred","year":"2012","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"2024070121173110000_pkae042-B7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1158\/1055-9965.Epi-09-0930","article-title":"Prevalence of tamoxifen use for breast cancer chemoprevention among U.S. women","volume":"19","author":"Waters","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"18","key":"2024070121173110000_pkae042-B8","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.1200\/jco.2009.27.8077","article-title":"Patient decisions about breast cancer chemoprevention: a systematic review and meta-analysis","volume":"28","author":"Ropka","year":"2010","journal-title":"J Clin Oncol"},{"issue":"7","key":"2024070121173110000_pkae042-B9","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1245\/s10434-019-07236-8","article-title":"Chemoprevention uptake for breast cancer risk reduction varies by risk factor","volume":"26","author":"Flanagan","year":"2019","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"2024070121173110000_pkae042-B10","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1200\/jco.2011.38.0261","article-title":"Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer","volume":"30","author":"Henry","year":"2012","journal-title":"J Clin Oncol"},{"issue":"1","key":"2024070121173110000_pkae042-B11","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/1471-2407-13-401","article-title":"Joint pain severity predicts premature discontinuation of aromatase inhibitors in breast cancer survivors","volume":"13","author":"Chim","year":"2013","journal-title":"BMC Cancer"},{"issue":"6","key":"2024070121173110000_pkae042-B12","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1158\/1055-9965.Epi-06-0034","article-title":"Breast density and parenchymal patterns as markers of breast cancer risk: A meta-analysis","volume":"15","author":"McCormack","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"2024070121173110000_pkae042-B13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1056\/NEJMoa062790","article-title":"Mammographic density and the risk and detection of breast cancer","volume":"356","author":"Boyd","year":"2007","journal-title":"N Engl J Med"},{"issue":"9","key":"2024070121173110000_pkae042-B14","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1093\/jnci\/djr079","article-title":"Tamoxifen-induced reduction in mammographic density and breast cancer risk reduction: a nested case-control study","volume":"103","author":"Cuzick","year":"2011","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"2024070121173110000_pkae042-B15","doi-asserted-by":"publisher","first-page":"457","DOI":"10.7326\/M15-2934","article-title":"Variation in mammographic breast density assessments among radiologists in clinical practice: a multicenter observational study","volume":"165","author":"Sprague","year":"2016","journal-title":"Annals of Internal Medicine"},{"issue":"8","key":"2024070121173110000_pkae042-B16","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1158\/1078-0432.Ccr-12-2789","article-title":"Mammographic breast density response to aromatase inhibition","volume":"19","author":"Vachon","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"12","key":"2024070121173110000_pkae042-B17","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1158\/1940-6207.Capr-11-0154","article-title":"Changes in breast density and circulating estrogens in postmenopausal women receiving adjuvant anastrozole","volume":"4","author":"Prowell","year":"2011","journal-title":"Cancer Prev Res"},{"issue":"4","key":"2024070121173110000_pkae042-B18","doi-asserted-by":"publisher","first-page":"pky071","DOI":"10.1093\/jncics\/pky071","article-title":"Adjuvant therapy and mammographic density changes in women with breast cancer","volume":"2","author":"Eriksson","year":"2018","journal-title":"JNCI Cancer Spectr"},{"issue":"4","key":"2024070121173110000_pkae042-B19","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.acra.2018.06.020","article-title":"Convolutional neural network based breast cancer risk stratification using a mammographic dataset","volume":"26","author":"Ha","year":"2019","journal-title":"Acad Radiol"},{"issue":"2","key":"2024070121173110000_pkae042-B20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s10549-023-06966-4","article-title":"Breast cancer risk prediction combining a convolutional neural network-based mammographic evaluation with clinical factors","volume":"200","author":"Michel","year":"2023","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"2024070121173110000_pkae042-B21","doi-asserted-by":"publisher","first-page":"e312","DOI":"10.1016\/j.clbc.2020.11.007","article-title":"Dynamic changes of convolutional neural network-based mammographic breast cancer risk score among women undergoing chemoprevention treatment","volume":"21","author":"Manley","year":"2020","journal-title":"Clin Breast Cancer"},{"issue":"7","key":"2024070121173110000_pkae042-B22","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1158\/1940-6207.Capr-18-0444","article-title":"Randomized double-blind placebo-controlled biomarker modulation study of vitamin D supplementation in premenopausal women at high risk for breast cancer (SWOG S0812)","volume":"12","author":"Crew","year":"2019","journal-title":"Cancer Prev Res"},{"issue":"13","key":"2024070121173110000_pkae042-B23","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1093\/jnci\/djs254","article-title":"A novel automated mammographic density measure and breast cancer risk","volume":"104","author":"Heine","year":"2012","journal-title":"JNCI J Natl Cancer Inst"},{"issue":"5","key":"2024070121173110000_pkae042-B24","doi-asserted-by":"publisher","first-page":"337","DOI":"10.7326\/0003-4819-148-5-200803040-00004","article-title":"Using clinical factors and mammographic breast density to estimate breast cancer risk: development and validation of a new predictive model","volume":"148","author":"Tice","year":"2008","journal-title":"Ann Intern Med"}],"container-title":["JNCI Cancer Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jncics\/advance-article-pdf\/doi\/10.1093\/jncics\/pkae042\/58011096\/pkae042.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jncics\/article-pdf\/8\/4\/pkae042\/58384818\/pkae042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jncics\/article-pdf\/8\/4\/pkae042\/58384818\/pkae042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T21:21:11Z","timestamp":1719868871000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jncics\/article\/doi\/10.1093\/jncics\/pkae042\/7685408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jncics\/pkae042","relation":{},"ISSN":["2515-5091"],"issn-type":[{"value":"2515-5091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8,1]]},"published":{"date-parts":[[2024,5,30]]},"article-number":"pkae042"}}