{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:18:35Z","timestamp":1781648315488,"version":"3.54.5"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Sigmoid colon cancer (SCC) is a common type of colorectal cancer, frequently leading to liver metastasis. Predicting cause-specific survival (CSS) and overall survival (OS) in SCC with liver metastasis (SCCLM) patients is challenging due to the lack of suitable models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from SCCLM patients (2010-2017) in the Surveillance, Epidemiology, and End Results (SEER) Program were recruited. Patients were split into training and validation groups (7:3). Prognostic factors were identified using competing risk and Cox proportional hazards models, and nomograms for CSS and OS were developed. Model performance was evaluated with the concordance index and calibration curves, with a two-sided p\u2009&amp;lt;\u2009.05 was considered statistically significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>4,981 SCCLM patients were included, with a median follow-up of 20\u2009months (IQR: 9-33\u2009months). During follow-up, 72.25% of patients died (68.44% from SCC, 3.81% from other causes). Age, race, grade, T stage, N stage, surgery, chemotherapy, CEA, tumor deposits, lung metastasis, and tumor size were prognostic factors for both CSS and OS. The models demonstrated good discrimination and calibration performance, with C-index values of 0.79 (95% CI: 0.78-0.80) for CSS and 0.74 (95% CI: 0.73-0.75) for OS. A web-based application for real-time CSS predictions was created, accessible at https:\/\/shuaishao.shinyapps.io\/SCCLM\/.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Prognostic factors for SCCLM patients were identified basing on SEER database, and nomograms for CSS and OS showed good performance. A web-based application was developed to predict SCCLM-specific survival, aiding in survival risk stratification.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkae080","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T15:37:34Z","timestamp":1726846654000},"source":"Crossref","is-referenced-by-count":1,"title":["Survival prediction in sigmoid-Colon-cancer patients with liver metastasis: a prospective cohort study"],"prefix":"10.1093","author":[{"given":"Shuai","family":"Shao","sequence":"first","affiliation":[{"name":"Capital Medical University Beijing Clinical Research Institute, Beijing Friendship Hospital, , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Tian","sequence":"additional","affiliation":[{"name":"Capital Medical University General Surgery Department, Beijing Friendship Hospital, , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Li","sequence":"additional","affiliation":[{"name":"Capital Medical University Beijing Clinical Research Institute, Beijing Friendship Hospital, , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wu","sequence":"additional","affiliation":[{"name":"Capital Medical University Beijing Clinical Research Institute, Beijing Friendship Hospital, , Beijing, China"},{"name":"Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease Department of Gastroenterology, Beijing Friendship Hospital, , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Chao-Yang Hospital, Capital Medical University Department of Gastroenterology, , Beijing, China"},{"name":"Capital Medical University Medical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, , Beijing, China"},{"name":"Capital Medical University School of Basic Medicine Beijing Laboratory of Oral Health, , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,20]]},"container-title":["JNCI Cancer Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jncics\/advance-article-pdf\/doi\/10.1093\/jncics\/pkae080\/59212741\/pkae080.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jncics\/advance-article-pdf\/doi\/10.1093\/jncics\/pkae080\/59212741\/pkae080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T15:37:35Z","timestamp":1726846655000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jncics\/advance-article\/doi\/10.1093\/jncics\/pkae080\/7762641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/jncics\/pkae080","relation":{},"ISSN":["2515-5091"],"issn-type":[{"value":"2515-5091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,20]]},"article-number":"pkae080"}}