{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:39:33Z","timestamp":1787827173917,"version":"build-2784847793"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"name":"Frederick National Laboratory\u2019s Laboratory Directed Exploratory Research"},{"name":"Samuel Waxman Cancer Research Foundation Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The consequence of diabetes on lung cancer overall survival (OS) is debated. This retrospective study used 2 large lung cancer databases to assess comprehensively diabetes effects on lung cancer OS in diverse demographic populations, including health disparity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The University of Texas MD Anderson Cancer Center database (32\u200a643 lung cancer patients with 11\u200a973 patients with diabetes) was extracted from electronic health records (EHRs) using natural language processing (NLP). Associations were between diabetes and lung cancer prognostic features (age, sex, race, body mass index [BMI], insurance status, smoking, stage, and histopathology). Hemoglobin A1C (HgbA1c) and glucose levels assessed glycemic control. Validation was with a Louisiana cohort (17\u200a768 lung cancer patients with 5402 patients with diabetes) enriched for health disparity cases. Kaplan-Meier analysis, log-rank test, multivariable Cox proportional hazard models, and survival tree analyses were employed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Lung cancer patients with diabetes exhibited marginally elevated OS or no statistically significant difference versus nondiabetic patients. When examining OS for 2 glycemic levels (HgbA1c &amp;gt; 7.0 or glucose &amp;gt; 154 mg\/dL vs HgbA1c &amp;gt; 9.0 or glucose &amp;gt; 215 mg\/dL), a statistically significant improvement in OS occurred in lung cancer patients with controlled versus uncontrolled glycemia (P &amp;lt; .0001). This improvement spanned sex, age, smoking status, insurance status, stage, race, BMI, histopathology, and therapy. Survival tree analysis revealed that obese and morbidly obese patients with controlled glycemia had higher lung cancer OS than comparison groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings indicate a need for optimal glycemic control to improve lung cancer OS in diverse populations with diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkae081","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T02:00:15Z","timestamp":1726279215000},"source":"Crossref","is-referenced-by-count":7,"title":["Glycemic control in diabetic patients improved overall lung cancer survival across diverse populations"],"prefix":"10.1093","volume":"8","author":[{"given":"Wayne Y","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-7376","authenticated-orcid":false,"given":"Brian","family":"Luke","sequence":"additional","affiliation":[{"name":"Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research , Frederick, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3663-5027","authenticated-orcid":false,"given":"Xiao-Cheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Louisiana State University Health Sciences Center , New Orleans, LA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5469-9214","authenticated-orcid":false,"given":"J Jack","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6101-5175","authenticated-orcid":false,"given":"Yong","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Louisiana State University Health Sciences Center , New Orleans, LA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3679-2915","authenticated-orcid":false,"given":"Samuel C","family":"Okpechi","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Frederick National Laboratory for Cancer Research , Frederick, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Gause","sequence":"additional","affiliation":[{"name":"Clinical Research Program, Frederick National Laboratory for Cancer Research , Frederick, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-5424","authenticated-orcid":false,"given":"Paras","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3079-5153","authenticated-orcid":false,"given":"Steven I","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-8029","authenticated-orcid":false,"given":"Augusto","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center , New Orleans, LA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-9085","authenticated-orcid":false,"given":"Ethan","family":"Dmitrovsky","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Frederick National Laboratory for Cancer Research , Frederick, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-1832","authenticated-orcid":false,"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Frederick National Laboratory for Cancer Research , Frederick, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"issue":"1","key":"2025040706301126300_pkae081-B1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin."},{"issue":"3","key":"2025040706301126300_pkae081-B2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.critrevonc.2005.04.008","article-title":"Prognostic impact of increasing age and co-morbidity in cancer patients: a population-based approach","volume":"55","author":"Janssen-Heijnen","year":"2005","journal-title":"Crit Rev Oncol Hematol."},{"issue":"6","key":"2025040706301126300_pkae081-B3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3892\/mco.2017.1224","article-title":"Survival of patients with lung cancer and diabetes mellitus","volume":"6","author":"Kurishima","year":"2017","journal-title":"Mol Clin Oncol."},{"issue":"1","key":"2025040706301126300_pkae081-B4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/bjc.2016.141","article-title":"Pre-existing diabetes and lung cancer prognosis","volume":"115","author":"Luo","year":"2016","journal-title":"Br J Cancer."},{"issue":"9933","key":"2025040706301126300_pkae081-B5","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/S0140-6736(14)60886-2","article-title":"The global implications of diabetes and cancer","volume":"383","author":"Shi","year":"2014","journal-title":"Lancet."},{"issue":"6865","key":"2025040706301126300_pkae081-B6","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/414782a","article-title":"Global and societal implications of the diabetes epidemic","volume":"414","author":"Zimmet","year":"2001","journal-title":"Nature."},{"issue":"3","key":"2025040706301126300_pkae081-B7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1001\/jamaoncol.2018.6619","article-title":"Risk of diabetes associated with cancer development","volume":"5","author":"Hu","year":"2019","journal-title":"JAMA Oncol."},{"issue":"9","key":"2025040706301126300_pkae081-B8","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1002\/ijc.22532","article-title":"Less aggressive treatment and worse overall survival in cancer patients with diabetes: a large population based analysis","volume":"120","author":"van de Poll-Franse","year":"2007","journal-title":"Int J Cancer."},{"issue":"11","key":"2025040706301126300_pkae081-B9","doi-asserted-by":"crossref","first-page":"e192553","DOI":"10.1001\/jamaoncol.2019.2553","article-title":"Effect of metformin plus tyrosine kinase inhibitors compared with tyrosine kinase inhibitors alone in patients with epidermal growth factor ceceptor-mutated lung adenocarcinoma: a phase 2 randomized clinical trial","volume":"5","author":"Arrieta","year":"2019","journal-title":"JAMA Oncol."},{"issue":"10","key":"2025040706301126300_pkae081-B10","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1158\/1078-0432.CCR-13-2613","article-title":"Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal","volume":"20","author":"Li","year":"2014","journal-title":"Clin Cancer Res."},{"issue":"23","key":"2025040706301126300_pkae081-B11","doi-asserted-by":"crossref","first-page":"6967","DOI":"10.1158\/1078-0432.CCR-19-0437","article-title":"Combination of metformin and Gefitinib as first-line therapy for nondiabetic advanced NSCLC patients with EGFR mutations: a randomized, double-blind phase II trial","volume":"25","author":"Li","year":"2019","journal-title":"Clin Cancer Res."},{"issue":"4","key":"2025040706301126300_pkae081-B12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1164\/rccm.201407-1395OC","article-title":"Survival of patients with stage IV lung cancer with diabetes treated with metformin","volume":"191","author":"Lin","year":"2015","journal-title":"Am J Respir Crit Care Med."},{"issue":"5","key":"2025040706301126300_pkae081-B13","first-page":"513","article-title":"Protective effect of diabetes against metastasis in patients with non-small cell lung cancer","volume":"167","author":"Hanbali","year":"2007","journal-title":"Arch Intern Med."},{"issue":"3","key":"2025040706301126300_pkae081-B14","doi-asserted-by":"crossref","first-page":"812","DOI":"10.2337\/diabetes.52.3.812","article-title":"Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study","volume":"52","author":"Spranger","year":"2003","journal-title":"Diabetes."},{"issue":"4","key":"2025040706301126300_pkae081-B15","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1572-0241.2003.07362.x","article-title":"Relationship between diabetes mellitus and the site of colorectal cancer","volume":"98","author":"Tomiyama","year":"2003","journal-title":"Am J Gastroenterol."},{"issue":"6","key":"2025040706301126300_pkae081-B16","first-page":"667","article-title":"Patients with diabetes-induced microangiopathy show a reduced frequency of carcinomas","volume":"12","author":"Nerlich","year":"1998","journal-title":"In Vivo"},{"issue":"6","key":"2025040706301126300_pkae081-B17","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.mehy.2005.01.015","article-title":"Possible participation of advanced glycation end products in the pathogenesis of colorectal cancer in diabetic patients","volume":"64","author":"Yamagishi","year":"2005","journal-title":"Med Hypotheses"},{"issue":"1","key":"2025040706301126300_pkae081-B18","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1530\/JME-13-0152","article-title":"A new link between diabetes and cancer: enhanced WNT\/beta-catenin signaling by high glucose","volume":"52","author":"Garcia-Jimenez","year":"2014","journal-title":"J Mol Endocrinol."},{"issue":"1","key":"2025040706301126300_pkae081-B19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12253-016-0086-1","article-title":"Biologic evaluation of diabetes and local recurrence in non-small cell lung cancer","volume":"23","author":"Yang","year":"2017","journal-title":"Pathol Oncol Res."},{"issue":"9","key":"2025040706301126300_pkae081-B20","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1097\/JTO.0b013e3182614877","article-title":"Prolonged survival in lung cancer patients with diabetes mellitus","volume":"7","author":"Kurishima","year":"2012","journal-title":"J Thorac Oncol."},{"issue":"1","key":"2025040706301126300_pkae081-B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5761\/atcs.ra.19-00170","article-title":"The effect of diabetes mellitus on prognosis of patients with non-small-cell lung cancer: a systematic review and meta-analysis","volume":"26","author":"Bi","year":"2020","journal-title":"Ann Thorac Cardiovasc Surg."},{"issue":"3","key":"2025040706301126300_pkae081-B22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/1759-7714.12985","article-title":"Diabetes mellitus and survival of non-small cell lung cancer patients after surgery: a comprehensive systematic review and meta-analysis","volume":"10","author":"Deng","year":"2019","journal-title":"Thorac Cancer."},{"issue":"31","key":"2025040706301126300_pkae081-B23","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1200\/JCO.2006.07.0243","article-title":"Impact of prediagnosis smoking, alcohol, obesity, and insulin resistance on survival in male cancer patients: National Health Insurance Corporation Study","volume":"24","author":"Park","year":"2006","journal-title":"J Clin Oncol."},{"key":"2025040706301126300_pkae081-B24","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/1471-2407-12-174","article-title":"Decreased survival among lung cancer patients with co-morbid tuberculosis and diabetes","volume":"12","author":"Shieh","year":"2012","journal-title":"BMC Cancer."},{"issue":"6","key":"2025040706301126300_pkae081-B25","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1007\/s00125-017-4229-z","article-title":"Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium","volume":"60","author":"Chen","year":"2017","journal-title":"Diabetologia."},{"issue":"6","key":"2025040706301126300_pkae081-B26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1159\/000323856","article-title":"Effect of diabetes mellitus on the outcome of patients with resected non-small cell lung carcinoma","volume":"57","author":"Bartling","year":"2011","journal-title":"Gerontology"},{"issue":"11","key":"2025040706301126300_pkae081-B27","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1097\/JTO.0b013e31822a75be","article-title":"Prolonged survival in patients with lung cancer with diabetes mellitus","volume":"6","author":"Hatlen","year":"2011","journal-title":"J Thorac Oncol."},{"issue":"14","key":"2025040706301126300_pkae081-B28","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1001\/archinte.160.14.2217","article-title":"Diabetes is associated with longer survival rates in patients with malignant tumors","volume":"160","author":"De Giorgio","year":"2000","journal-title":"Arch Intern Med."},{"issue":"2","key":"2025040706301126300_pkae081-B29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2337\/diacare.23.2.187","article-title":"Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. population","volume":"23","author":"Rohlfing","year":"2000","journal-title":"Diabetes Care."},{"issue":"9713","key":"2025040706301126300_pkae081-B30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0140-6736(09)61969-3","article-title":"Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort study","volume":"375","author":"Currie","year":"2010","journal-title":"Lancet."},{"issue":"suppl 1","key":"2025040706301126300_pkae081-B31","first-page":"S83","article-title":"American Diabetes Association Professional Practice Committee. 6. Glycemic targets: standards of medical care in diabetes\u20132022","volume":"45","year":"2022","journal-title":"Diabetes Care."},{"key":"2025040706301126300_pkae081-B32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.diabres.2016.12.009","article-title":"Optimal glycemic target level for colon cancer patients with diabetes","volume":"124","author":"Lee","year":"2017","journal-title":"Diabetes Res Clin Pract."},{"issue":"1","key":"2025040706301126300_pkae081-B33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.6004\/jnccn.2014.0006","article-title":"Baseline hemoglobin-A1c impacts clinical outcomes in patients with pancreatic cancer","volume":"12","author":"Fan","year":"2014","journal-title":"J Natl Compr Canc Netw."},{"issue":"3","key":"2025040706301126300_pkae081-B34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10238-018-0497-2","article-title":"Good glycaemic control is associated with a better prognosis in breast cancer patients with type 2 diabetes mellitus","volume":"18","author":"Chang","year":"2018","journal-title":"Clin Exp Med."},{"issue":"5","key":"2025040706301126300_pkae081-B35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/jso.24989","article-title":"Prognostic factors for resected non-small cell lung cancer in patients with type 2 diabetes mellitus","volume":"117","author":"Yu","year":"2018","journal-title":"J Surg Oncol."},{"issue":"1","key":"2025040706301126300_pkae081-B36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12885-019-5370-5","article-title":"Fasting plasma glucose is an independent predictor of survival in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy","volume":"19","author":"Bergamino","year":"2019","journal-title":"BMC Cancer."},{"key":"2025040706301126300_pkae081-B37","doi-asserted-by":"crossref","first-page":"745150","DOI":"10.3389\/fonc.2021.745150","article-title":"The survival benefit for optimal glycemic control in advanced non-small cell lung cancer patients with preexisting diabetes mellitus","volume":"11","author":"Qian","year":"2021","journal-title":"Front Oncol"},{"issue":"9","key":"2025040706301126300_pkae081-B38","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/JTO.0b013e31829cf942","article-title":"Body mass index and its association with clinical outcomes for advanced non-small-cell lung cancer patients enrolled on Eastern Cooperative Oncology Group clinical trials","volume":"8","author":"Dahlberg","year":"2013","journal-title":"J Thorac Oncol."},{"issue":"10","key":"2025040706301126300_pkae081-B39","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.jtho.2017.07.022","article-title":"Obesity paradox in lung cancer prognosis: evolving biological insights and clinical implications","volume":"12","author":"Zhang","year":"2017","journal-title":"J Thorac Oncol."},{"issue":"8","key":"2025040706301126300_pkae081-B40","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.jtho.2017.05.010","article-title":"The influence of body mass index on overall survival following surgical resection of non-small cell lung cancer","volume":"12","author":"Sepesi","year":"2017","journal-title":"J Thorac Oncol."},{"issue":"7","key":"2025040706301126300_pkae081-B41","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1158\/2767-9764.CRC-22-0179","article-title":"Real-world studies link nonsteroidal anti-inflammatory drug use to improved overall lung cancer survival","volume":"2","author":"Roszik","year":"2022","journal-title":"Cancer Res Commun."},{"issue":"7","key":"2025040706301126300_pkae081-B42","doi-asserted-by":"crossref","first-page":"e3042","DOI":"10.1002\/dmrr.3042","article-title":"Obesity and diabetes\u2014not only a simple link between two epidemics","volume":"34","author":"Chobot","year":"2018","journal-title":"Diabetes Metab Res Rev"},{"key":"2025040706301126300_pkae081-B43","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2147\/DMSO.S67400","article-title":"Mechanism linking diabetes mellitus and obesity","volume":"7","author":"Al-Goblan","year":"2014","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"3","key":"2025040706301126300_pkae081-B44","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1001\/jamaoncol.2021.7015","article-title":"Association of BMI with benefit of metformin plus epidermal growth factor receptor-tyrosine kinase inhibitors in patients with advanced lung adenocarcinoma: a secondary analysis of a phase 2 randomized clinical trial","volume":"8","author":"Arrieta","year":"2022","journal-title":"JAMA Oncol."},{"key":"2025040706301126300_pkae081-B45","volume-title":"Survminer: drawing survival curves using 'ggplot2'","author":"Kassambara"},{"key":"2025040706301126300_pkae081-B46","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-3294-8","volume-title":"Modeling survival data: extending the Cox model","author":"Therneau","year":"2000"},{"key":"2025040706301126300_pkae081-B47","author":"Therneau"},{"key":"2025040706301126300_pkae081-B48","author":"Herneau"},{"key":"2025040706301126300_pkae081-B49","author":"Hothorn"}],"container-title":["JNCI Cancer Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jncics\/advance-article-pdf\/doi\/10.1093\/jncics\/pkae081\/59107326\/pkae081.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jncics\/article-pdf\/8\/5\/pkae081\/59748222\/pkae081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jncics\/article-pdf\/8\/5\/pkae081\/59748222\/pkae081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:34:23Z","timestamp":1744007663000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jncics\/article\/doi\/10.1093\/jncics\/pkae081\/7756410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jncics\/pkae081","relation":{},"ISSN":["2515-5091"],"issn-type":[{"value":"2515-5091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,9,2]]},"article-number":"pkae081"}}