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Causal mediation analysis was tested using the bootstrapping method to examine associations between PA, cognitive difficulties, and other sociodemographic characteristics. Results showed statistically significant disparities in both CD and physical inactivity among CS with low education, low income, high poverty, and certain age categories. Health disparities related to CD based on race\/ethnicity, sex, and age were also identified. Physical activity mediated the relationship between CD and education, income, poverty, and age. Future research is needed to gain deeper insight into the mechanisms of PA-induced health benefits and to develop specific PA prescription guidelines in the subgroups at risk for CD.<\/jats:p>","DOI":"10.1093\/jncics\/pkaf023","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T21:54:06Z","timestamp":1741125246000},"source":"Crossref","is-referenced-by-count":2,"title":["The mediating role of physical activity on cognitive disparities in cancer survivors"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-939X","authenticated-orcid":false,"given":"Jaimi L","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences , Little Rock, AR,","place":["United States"]},{"name":"Winthrop P. 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