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Data collected includes demographics, medical history, family history, and lifestyle risk factors from patient-completed surveys. Vital status, cause of death, treatment, and clinicopathological characteristics were obtained through medical chart abstraction, pathology reports, and\/or linkage to state cancer registries. Blood, saliva, or normal colonic tissues were used to extract and genotype germline DNA. Tumor tissue (snap frozen or formalin-fixed paraffin-embedded) was evaluated by pathologists for diagnosis, tissue content, tumor cellularity, necrosis, immune infiltration, and additional histopathological characteristics. A centralized database with a virtual tumor repository was created to facilitate collaborative research.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>As of April 2024, LC3 assembled data from 2210 patients (diagnosed 1994 to 2023). The mean age at diagnosis was 57 (range: 19\u201393) years; 54.3% of participants were male, and 62.0% had been diagnosed with colon cancer. Surveys were completed by 1722 (77.8%) participants. Ongoing multi-omics profiling on up to 600 patients include: genome-wide germline genotyping, paired tumor\/normal whole exome sequencing, bulk RNA-seq, T cell receptor immunosequencing, and multiplex immunofluorescence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This consortium fills an important gap in research infrastructure in CRC as well as improving precision medicine initiatives for all individuals.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkaf027","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T20:21:44Z","timestamp":1742588504000},"source":"Crossref","is-referenced-by-count":1,"title":["Building research infrastructure to advance precision medicine in colorectal cancer"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5931-1194","authenticated-orcid":false,"given":"Stephanie L","family":"Schmit","sequence":"first","affiliation":[{"name":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic , Cleveland, OH,","place":["United States"]},{"name":"Population and Cancer Prevention Program, Case Comprehensive Cancer Center , Cleveland, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-3157","authenticated-orcid":false,"given":"Nicole C","family":"Loro\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sobieski","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic , Cleveland, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9468-0664","authenticated-orcid":false,"given":"Marco","family":"Matejcic","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic , Cleveland, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4282-103X","authenticated-orcid":false,"given":"Nathalie T","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-9671","authenticated-orcid":false,"given":"Hannah J","family":"Hoehn","sequence":"additional","affiliation":[{"name":"Non-Therapeutic Research Office, H. Lee Moffitt Cancer Center & Research Institute , Tampa, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana B","family":"Diaz","sequence":"additional","affiliation":[{"name":"Non-Therapeutic Research Office, H. 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