{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:17:33Z","timestamp":1784603853604,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017012","name":"Children\u2019s Oncology Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017012","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NCI Community Oncology Research Program"},{"name":"Research Base","award":["UG1CA189955"],"award-info":[{"award-number":["UG1CA189955"]}]},{"DOI":"10.13039\/100017012","name":"Children\u2019s Oncology Group","doi-asserted-by":"publisher","award":["U10CA180899"],"award-info":[{"award-number":["U10CA180899"]}],"id":[{"id":"10.13039\/100017012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017012","name":"Children\u2019s Oncology Group","doi-asserted-by":"publisher","award":["U10CA180886"],"award-info":[{"award-number":["U10CA180886"]}],"id":[{"id":"10.13039\/100017012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006316","name":"Alliance for Clinical Trials in Oncology","doi-asserted-by":"crossref","award":["UG1CA189823"],"award-info":[{"award-number":["UG1CA189823"]}],"id":[{"id":"10.13039\/100006316","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SWOG","award":["UG1CA189974"],"award-info":[{"award-number":["UG1CA189974"]}]},{"DOI":"10.13039\/100017788","name":"ECOG-ACRIN","doi-asserted-by":"publisher","award":["UG1CA189828"],"award-info":[{"award-number":["UG1CA189828"]}],"id":[{"id":"10.13039\/100017788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Individuals diagnosed with acute lymphoblastic leukemia (ALL) between adolescents and young adults aged 15-39 years face poor survival and unique challenges. We evaluated facility-level factors and guideline-concordant care among adolescents and young adults with ALL at National Cancer Institute Community Oncology Research Program (NCORP) practices.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We assembled a retrospective cohort of adolescents and young adults aged 15-39 years with ALL treated at participating NCORPs between 2012 and 2016. NCORPs abstracted patient data and completed facility-level questionnaires for each clinical facility (study-defined criteria). The central review committee adjudicated whether treatment was concordant with adolescent and young adult\u2013specific National Comprehensive Cancer Network ALL guidelines (ie, pediatric-inspired therapy or clinical trial). Guideline-concordant care was described by age, facility model (adult\/internal medicine, pediatric, mixed [pediatric services within a general hospital]), and average annual adolescents and young adult ALL volume. Generalized linear mixed effects models estimated the odds of guideline-concordant care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Adolescents and young adults receiving guideline-concordant care were younger (n\u2009=\u2009196; median\u2009=\u200919.5 years) than those who did not (n\u2009=\u200931; median\u2009=\u200932.1 years). Guideline-concordant care was observed in many adolescents and young adults aged 22-39 years (68.8%), and nearly universal in those aged 15-21\u2009years. In multivariable analyses, adolescents and young adults at adult\/internal medicine clinical facilities had lower odds of guideline-concordant care (odds ratio =\u20090.02, 95% confidence interval = 0.0 to 0.18); there was no statistically significant association between annual adolescent and young ALL volume and receiving guideline-concordant care. Guideline-concordant care was observed more often in adult\/internal medicine and\/or mixed clinical facilities with communication between adult or pediatric counterparts, adolescents and young adult ALL clinical pathways, and\/or adolescent and young adult\u2013specific meetings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Guideline-concordant care among adolescents and young adults with ALL (specifically pediatric-inspired therapy) at NCORPs is associated with facility model (adult\/internal medicine) but not adolescent and young adult ALL volume. Strategies to improve guideline-concordant care could include facilitating communication and clinical pathways at adult\/internal medicine clinical facilities treating adolescent and young adult ALL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkaf033","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T15:45:18Z","timestamp":1744818318000},"source":"Crossref","is-referenced-by-count":2,"title":["Guideline-concordant treatment among adolescents and young adults with acute lymphoblastic leukemia"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-2239","authenticated-orcid":false,"given":"Julie A","family":"Wolfson","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology-Oncology, University of Alabama at Birmingham , Birmingham, AL,","place":["United States"]},{"name":"Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham , Birmingham, AL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-2778","authenticated-orcid":false,"given":"Allison C","family":"Grimes","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology-Oncology, University of Texas Health Science Center San Antonio , San Antonio, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-929X","authenticated-orcid":false,"given":"Michelle M","family":"Nu\u00f1o","sequence":"additional","affiliation":[{"name":"Children\u2019s Oncology Group , Monrovia, CA,","place":["United States"]},{"name":"Department of Population and Public Health Sciences, University of Southern California , Los Angeles, CA,","place":["United 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States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh B","family":"Boayue","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology-Oncology, University of New Mexico Cancer Center , Albuquerque, NM,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-2736","authenticated-orcid":false,"given":"Charlotte L","family":"Kerber","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of California , Davis, Davis, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Ponce","sequence":"additional","affiliation":[{"name":"Children\u2019s Oncology Group , Monrovia, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Vargas","sequence":"additional","affiliation":[{"name":"Children\u2019s Oncology Group , Monrovia, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-5361","authenticated-orcid":false,"given":"George J","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Colon and Rectal Surgery and Department of Health Services Research, The University of Texas, MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8349-9200","authenticated-orcid":false,"given":"Wendy","family":"Stock","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, University of Chicago Medicine , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8807-153X","authenticated-orcid":false,"given":"Dawn","family":"Hershman","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Columbia University, New York , NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Curran","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, University of Cincinnati , Cincinnati, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Advani","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Cleveland Clinic, Taussig Cancer Institute , Cleveland, OH,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-8198","authenticated-orcid":false,"given":"Kristen","family":"O\u2019Dwyer","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, University of Rochester, Wilmot Cancer Institute , Rochester, NY,","place":["United 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