{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:35Z","timestamp":1792785995994,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mentored Patient Oriented Career Research Development Award","award":["1-K08CA230170-01A1"],"award-info":[{"award-number":["1-K08CA230170-01A1"]}]},{"name":"Sub-Saharan African Collaborative HIV"},{"name":"Cancer Consortia-U54","award":["1U54 CA190158-01"],"award-info":[{"award-number":["1U54 CA190158-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cervical cancer is a leading morbidity\/mortality cause, frequently co-occurring with human immunodeficiency virus (HIV) positivity, in Botswana. We examined long-term outcomes for Ipabalele study participants receiving curative chemoradiation for locally advanced cervical cancer (2015-2019) by HIV status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and outcome data were collected at baseline, treatment completion, and 3\u2009months thereafter. Patients were followed for up to 5\u2009years. Overall survival (OS) was evaluated using Kaplan-Meier curves and Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort comprised 295 patients (73.8% with HIV, younger at diagnosis [P\u2009&amp;lt;\u2009.001]) followed for a median of 44.2\u2009months. Complete response was seen in 217\/278 (76.1%) patients. Two- and 5-year OS rates were 73.4% and 59.9%, respectively, with no difference by HIV status. OS was associated negatively with advanced disease stage (III: hazard ratio [HR] 13.23, P\u2009&amp;lt;\u2009.001; IV: HR 7.8, P\u2009=\u2009.008) and positively with increased radiation (HR 0.977, P\u2009=\u2009.0005) and chemotherapy (HR 0.85, P\u2009=\u2009.005). Clinical response was associated negatively with advanced disease (IV: HR 0.113, P\u2009=\u2009.002) and positively with increased radiation (P\u2009=\u2009.009). Toxicity did not differ by HIV status. The most common grade-\u2265-2 non-hematological and hematological toxicities were radiation dermatitis (39.8%) and reduced white blood cell count (66.05%), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this cervical cancer cohort with good HIV status control, treatment outcomes and OS were associated with disease and treatment factors, not the HIV status. Early screening and education regarding treatment protocols are crucial to improve cervical cancer outcomes in Botswana.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkaf045","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T07:52:34Z","timestamp":1746431554000},"source":"Crossref","is-referenced-by-count":2,"title":["Cervical cancer treatment outcomes and survival in Botswana by human immunodeficiency virus status:\n                    <i>Ipabalele<\/i>\n                    study results"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-5937","authenticated-orcid":false,"given":"Surbhi","family":"Grover","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Perelman School of Medicine , Philadelphia, PA,","place":["United States"]},{"name":"Botswana-University of Pennsylvania Partnership , 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Gaborone,","place":["Botswana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7681-8966","authenticated-orcid":false,"given":"Lilie L","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-6219","authenticated-orcid":false,"given":"Shalini","family":"Vinod","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales , Sydney,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark N","family":"Polizzotto","sequence":"additional","affiliation":[{"name":"Clinical Hub for Interventional Research, The Australian National University College of Health and Medicine , 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