{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:15:40Z","timestamp":1788056140358,"version":"build-2784847793"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with cancer are at a higher risk of tuberculosis (TB) infection because of the immunosuppressive effect of prolonged chemotherapy. This study determined the prevalence of TB and TB-related deaths among patients with cancer from a global perspective.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to conduct the current study. Extracted data from relevant articles were analyzed using Stata, version 17.0, software (StataCorp LP). The effect size estimate was computed using a random-effects model, considering a 95% confidence interval (CI). The I2 statistic and Galbraith plot were used to confirm heterogeneity. A univariate meta-regression, sensitivity, and subgroup analyses were conducted to identify the source of heterogeneity. The Egger test and a funnel plot were used to check publication bias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the 13 articles, of the 2\u200a135\u200a402 patients with malignancy, 31\u200a073 had TB. The pooled estimate of TB was 3.69% (95% CI\u2009=\u20091.79% to 5.58%), with high heterogeneity (I2\u2009=\u200999.99%). The pooled TB prevalence in Europe was 7.04 (95% CI\u2009=\u20091.09% to 12.99%). The prevalence of TB in a single study in North America was 8.78% (95% CI\u2009=\u20098.45% to 9.10%). A higher TB prevalence was observed in patients with solid tumors (6.84%, 95% CI\u2009=\u20094.30% to 9.38%), followed by hematologic malignancies and solid tumors (3.63%, 95% CI\u2009=\u20091.46% to 5.80%). Pulmonary and extrapulmonary TB were 3.05% and 0.77%, respectively. The rate of TB-related death was 0.04%. In meta-regression, publication year and sample size did not affect heterogeneity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There is a considerable burden of TB (3.69%) in patients with cancer, which calls for routine TB screening and early treatment of cases to reduce complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkaf062","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T07:54:26Z","timestamp":1749196466000},"source":"Crossref","is-referenced-by-count":2,"title":["Burden of tuberculosis among patients with cancer: a comprehensive systematic review and meta-analysis of global data"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-8809","authenticated-orcid":false,"given":"Muluneh","family":"Assefa","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Gondar 196,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5532-6097","authenticated-orcid":false,"given":"Mitkie","family":"Tigabie","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Gondar 196,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1098-6892","authenticated-orcid":false,"given":"Azanaw","family":"Amare","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Gondar 196,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mebratu","family":"Tamir","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Gondar 196,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5950-5438","authenticated-orcid":false,"given":"Abebaw","family":"Setegn","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Gondar 196,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3797-6096","authenticated-orcid":false,"given":"Yenesew Mihret","family":"Wondmagegn","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Gondar 196,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-1108","authenticated-orcid":false,"given":"Sirak","family":"Biset","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar , Gondar 196,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8435-1208","authenticated-orcid":false,"given":"Wesam Taher","family":"Almagharbeh","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Nursing, Faculty of Nursing, University of Tabuk , Tabuk,","place":["Saudi 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