{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:26:49Z","timestamp":1789032409032,"version":"build-2803163510"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM104416"],"award-info":[{"award-number":["P20GM104416"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics","doi-asserted-by":"publisher","award":["CP010125-24"],"award-info":[{"award-number":["CP010125-24"]}],"id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P42ES007373"],"award-info":[{"award-number":["P42ES007373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Exposure to arsenic in drinking water may interact with common genetic variants in urinary bladder cancer risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a gene-environment interaction analysis among 1091 bladder cancer cases and 928 controls from the New England Bladder Cancer Study. Genetic variants tested as effect modifiers included those associated with bladder cancer and arsenic metabolism. Interactions with disease-specific polygenic scores and a genome-wide gene-environment interaction analysis were also conducted. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated with average arsenic concentration (\u00b5g\/L), average daily arsenic (\u00b5g\/day), and cumulative arsenic (mg) in water as exposures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Multiplicative interactions for bladder cancer risk were identified for cumulative arsenic and rs1046428 of GSTZ1 on 14q23 (TT and TC genotype: ORT3vsT1 = 1.44, 95% CI = 1.05 to 1.98; Pinteraction= .01) and for average daily arsenic and rs1801133 (C677T) and rs1801131 (A1298C) of MTHFR on 1p36 (TT and TC genotypes: ORT3vsT1 = 1.53, 95% CI = 1.06 to 2.23; Pinteraction= .02; CC and CA genotype: ORT3vsT1 = 1.63, 95% CI = 1.16 to 2.29; Pinteraction=.01, respectively). A global interaction between arsenic exposure and polygenic scores was also observed (ORT3vsT1 = 1.80, 95% CI = 1.26 to 2.56; Pinteraction=. 01). Genome-wide gene-environment interaction analyses suggested interactions with 5 loci with a Pinteraction of no more than 5e-6.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Genetic variants that function in arsenic metabolism involving folate and oxidative stress pathways and a global summary of genetic susceptibility to bladder cancer may modify the association between elevated arsenic exposure from drinking water and bladder cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pkaf064","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T07:49:32Z","timestamp":1749800972000},"source":"Crossref","is-referenced-by-count":2,"title":["Lifetime water arsenic, genetic susceptibility, and bladder cancer in the New England Bladder Cancer Study"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9245-4576","authenticated-orcid":false,"given":"Hugo","family":"Pomares-Millan","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center , Hanover, Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-5485","authenticated-orcid":false,"given":"Stella","family":"Koutros","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health , Bethesda, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6520-9249","authenticated-orcid":false,"given":"Dalsu","family":"Baris","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health , Bethesda, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Schwenn","sequence":"additional","affiliation":[{"name":"Formerly Maine Cancer Registry , Augusta, ME,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-1191","authenticated-orcid":false,"given":"Alison","family":"Johnson","sequence":"additional","affiliation":[{"name":"Formerly Vermont Department of Health , Burlington, VT,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Rothman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health , Bethesda, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra T","family":"Silverman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health , Bethesda, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D","family":"Leach","sequence":"additional","affiliation":[{"name":"Dartmouth Cancer Center, Dartmouth College , Hanover, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R","family":"Karagas","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center , Hanover, Lebanon, NH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6804-2528","authenticated-orcid":false,"given":"Michael N","family":"Passarelli","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Geisel 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