{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:12:40Z","timestamp":1774307560499,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Black men in the United States bear a disproportionate share of the prostate cancer (PCa) burden, with more than 50% higher incidence and double the mortality compared with White men. Previous studies have examined racial disparities in the incidence of fatal PCa (fPCa), defined as diagnosis leading to disease-specific death within 10\u2009years,\u00a0and found that they are greater in younger vs older men. However, the extent to which these trends are driven by disparities in incidence or survival is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conduct a retrospective analysis of data from the Surveillance, Epidemiology, and End Results program over the period 1980-2009 to decompose the incidence of fPCa into incidence and 10-year probability of death and quantify the relative disparities in these metrics by age at diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>We find that relative PCa incidence for Black vs White men significantly decreases by 0.116 units with each successive 5-year age group (95% CI\u2009=\u2009\u22120.183 to \u22120.049) but the relative probability of death within 10\u2009years does not differ significantly by age (slope\u2009=\u2009\u22120.012, 95% CI\u2009=\u2009\u22120.060 to 0.035). Further, this deconstruction is similar before and after the introduction of prostate-specific antigen screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We conclude that higher relative incidence of fPCa in young Black men vs young White men appears to be largely driven by their significantly increased incidence of disease. This finding supports investigating targeted screening of Black men beginning at younger ages than White men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkaf103","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:25:10Z","timestamp":1760959510000},"source":"Crossref","is-referenced-by-count":1,"title":["Age-specific racial disparities in the incidence of fatal prostate cancer: an analytic deconstruction"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1132-6244","authenticated-orcid":false,"given":"Mohamed","family":"Albirair","sequence":"first","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, WA,","place":["United States"]},{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-6749","authenticated-orcid":false,"given":"Yaw","family":"Nyame","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United States"]},{"name":"Department of Urology, University of Washington Medical Center , Seattle, WA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-6567","authenticated-orcid":false,"given":"Roman","family":"Gulati","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9164-6370","authenticated-orcid":false,"given":"Ruth","family":"Etzioni","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Fred Hutchinson Cancer Center , Seattle, WA,","place":["United States"]},{"name":"Department of Health Systems and Population Health, University of Washington , Seattle, WA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"2025120911274286800_pkaf103-B1","doi-asserted-by":"publisher","first-page":"606","DOI":"10.3390\/ijerph16040606","article-title":"Reducing racial inequities in health: using what we already know to take action","volume":"16","author":"Williams","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"2025120911274286800_pkaf103-B2","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41416-020-01038-6","article-title":"Cancer health disparities in racial\/ethnic minorities in the United States","volume":"124","author":"Zavala","year":"2021","journal-title":"Br J Cancer"},{"key":"2025120911274286800_pkaf103-B3","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3322\/caac.21340","article-title":"Cancer statistics for African Americans, 2016: progress and opportunities in reducing racial disparities: cancer statistics for African Americans, 2016","volume":"66","author":"DeSantis","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"2025120911274286800_pkaf103-B4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3322\/caac.21555","article-title":"Cancer statistics for African Americans, 2019","volume":"69","author":"DeSantis","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"2025120911274286800_pkaf103-B5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fpubh.2015.00051","article-title":"Health disparities and cancer: racial disparities in cancer mortality in the United States, 2000\u20132010","volume":"3","author":"O\u2019Keefe","year":"2015","journal-title":"Front Public Health"},{"key":"2025120911274286800_pkaf103-B6","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1001\/jamaoncol.2019.0826","article-title":"Association of Black race with prostate cancer\u2013specific and other-cause mortality","volume":"5","author":"Dess","year":"2019","journal-title":"JAMA Oncol"},{"key":"2025120911274286800_pkaf103-B7","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1002\/cncr.33152","article-title":"Racial disparities in mortality for patients with prostate cancer after radical prostatectomy","volume":"127","author":"Wen","year":"2021","journal-title":"Cancer"},{"key":"2025120911274286800_pkaf103-B8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41391-021-00451-z","article-title":"Racial disparities in prostate cancer among Black men: epidemiology and outcomes","volume":"25","author":"Chowdhury-Paulino","year":"2021","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"2025120911274286800_pkaf103-B9","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1002\/cncr.30687","article-title":"Is prostate cancer different in Black men? 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