{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:27:13Z","timestamp":1780975633386,"version":"3.54.1"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"American Heart Association-Strategically Focused Research Network Grant in Disparities in Cardio-Oncology","award":["#847740"],"award-info":[{"award-number":["#847740"]}]},{"name":"American Heart Association-Strategically Focused Research Network Grant in Disparities in Cardio-Oncology","award":["#863620"],"award-info":[{"award-number":["#863620"]}]},{"name":"Department of Defense Prostate Cancer Research Program\u2019s Physician Research","award":["#HT94252310158"],"award-info":[{"award-number":["#HT94252310158"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Socioeconomic position (SEP) is a fundamental social determinant of health (SDoH) contributing to observed disparities in cancer and cardiovascular (CV) care among individuals with prostate cancer (PC). Understanding the influence of SEP on CV health is essential for addressing outcome inequities within this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study utilizing Surveillance, Epidemiology, and End Results (SEER)-Medicare to evaluate CV outcomes in patients \u226565\u2009years with PC from 2009 to 2017. We studied the impact of SEP on cardiovascular events (CVEs), cardiovascular mortality (CVm), PC-specific mortality (PCsm), and all-cause mortality. CVE, CVm, and PCsm were analyzed using competing risk models and all-cause mortality with Cox proportional hazards models. A subgroup analysis was performed in Non-Hispanic Black and Non-Hispanic White individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 141\u00a0242 patients of whom 76\u00a0844 were in high SEP areas (45.6%) and 64\u00a0398 in low SEP ones (54.4%). Both groups had a mean age of 72\u2009years; patients in low SEP areas were 67.5% Non-Hispanic White, 34.4% having diabetes, 73.3% hypertension, and 67.7% dyslipidemia versus the high SEP group with 85.6% Non-Hispanic White, 30.4% diabetes, 69.9% hypertension, and 70.7% dyslipidemia. Patients in low SEP areas had higher risks of CVm (subdistribution hazard ratio [sHR] = 1.18, 95% CI = 1.12 to 1.25), PCsm (sHR = 1.12, 95% CI = 1.06 to 1.17), CVE (sHR = 1.07, 95% CI = 1.04 to 1.09), and all-cause mortality (HR 1.16, 95% CI = 1.13 to 1.20). Accentuated results were shown in the Non-Hispanic Black subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adverse SEP plays a significant role in shaping outcomes among older patients with PC, contributing to elevated risks of adverse CV and survival outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkaf113","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T13:12:14Z","timestamp":1764162734000},"source":"Crossref","is-referenced-by-count":3,"title":["Socioeconomic position and its effect on cardiovascular outcomes and mortality in patients with prostate cancer"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4584-3308","authenticated-orcid":false,"given":"Tarek","family":"Nahle","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , Augusta, GA,","place":["United States"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8361-9068","authenticated-orcid":false,"given":"Omar M","family":"Makram","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , Augusta, GA,","place":["United States"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA,","place":["United States"]},{"name":"Department of Medicine, Medical College of Georgia at Augusta University , Augusta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5850-9862","authenticated-orcid":false,"given":"Viraj R","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , Augusta, GA,","place":["United States"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-7956","authenticated-orcid":false,"given":"Harikrishnan","family":"Hyma Kunhiraman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University , Augusta, GA,","place":["United States"]},{"name":"Cardio-Oncology Program, Medical College of Georgia at Augusta University , Augusta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3134-0326","authenticated-orcid":false,"given":"Muhammad Umar","family":"Afzal","sequence":"additional","affiliation":[{"name":"Mayo Clinic Comprehensive Cancer Center , Phoenix, AZ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-0311","authenticated-orcid":false,"given":"Irbaz Bin","family":"Riaz","sequence":"additional","affiliation":[{"name":"Mayo Clinic Comprehensive Cancer Center , Phoenix, AZ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1076-0428","authenticated-orcid":false,"given":"Neeraj","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah , Salt Lake City, UT,","place":["Unites 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