{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:28:36Z","timestamp":1785547716934,"version":"3.56.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Professor Martin Tattersall Early Career Researcher Award Scheme"},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health Medical Research Council","award":["APP1176221"],"award-info":[{"award-number":["APP1176221"]}]},{"name":"National Health Medical Research Council","award":["APP1176221"],"award-info":[{"award-number":["APP1176221"]}]},{"DOI":"10.13039\/501100001026","name":"National Breast Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Weight gain and physical inactivity during chemotherapy for patients with early-stage breast cancer are common. We sought to investigate the feasibility of a virtual lifestyle (exercise and diet) intervention for breast cancer survivors during chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-arm phase 2 trial delivered 12 weekly 1-hour telehealth sessions of supervised exercise and diet education to breast cancer survivors (patients with stage I-III disease) starting neoadjuvant chemotherapy. Screening, recruitment, intervention, and study assessments completed at baseline (T0), immediately after the intervention (T1), and 3 months after the intervention (T2) were conducted by telehealth in 2022-2023. The primary outcome was that at least 60% of participants achieved 50% of the predetermined exercise and dietary goals. Secondary outcomes were acceptability (participation, attendance, completion), physical health, and lifestyle outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 73 referrals, 60 individuals were eligible, 58 (97%) provided consent, 51 (85%) commenced the intervention, and 34 (57%) completed at least 1 postintervention assessment (completion rate\u2009=\u200967%). The mean (SD) age of participants was 51 (8.8)\u2009years, and 50% of participants were receiving neoadjuvant chemotherapy. Attendance was lower for exercise than for diet sessions (44% vs 62% attended \u226575% sessions). At T1, 36% of participants adhered to at at least 50% of the preset goals, improving at T2 (62.5%). Weight was not statistically significantly different between T0 and T1 (P\u2009=\u2009.199) but increased substantially at T2 (P\u2009=\u2009.018). Average waist circumference was reduced at T1 (\u20121.9\u2009cm, P\u2009=\u2009.014) and at T2 (\u20123.3\u2009cm, P\u2009&amp;lt;\u2009.001). Weekly exercise time increased by 38.5 minutes from T0 to T1 (P\u2009=\u2009.038), and the proportion of participants who met exercise guidelines improved from 6% (T0) to 41% (T2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our primary outcome was not achieved immediately after the intervention but was observed 3 months later. Individuals completing the intervention attended at least half the diet and exercise sessions during chemotherapy. Results of this study will inform design of a phase 3 study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkaf122","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:12:18Z","timestamp":1769515938000},"source":"Crossref","is-referenced-by-count":2,"title":["Feasibility evaluation of a virtual lifestyle intervention for early-stage breast cancer survivors undergoing chemotherapy"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-9395","authenticated-orcid":false,"given":"Sim Yee (Cindy)","family":"Tan","sequence":"first","affiliation":[{"name":"Concord Cancer Centre, Concord Repatriation General Hospital , NSW,","place":["Australia"]},{"name":"Faculty of Health and Medicine, University of Sydney , Sydney, NSW,","place":["Australia"]},{"name":"Nutrition and Dietetics Department, Concord Hospital , Concord, 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