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Ewing Foundation Endowed Chair of Hematology and Oncology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cognitive effects of breast cancer antiestrogen endocrine therapy are a salient concern for survivors, given the growing evidence that estrogen plays a role in late-life dementia risk. The APOE4 genotype has been linked with risk for cognitive difficulties, studied mainly in younger cancer survivors. We found that women aged 60+ with nonmetastatic breast cancer enrolled in the prospective Thinking and Living with Cancer study who underwent endocrine therapy had lower subjective (P\u2009=\u2009.06) and objective (P\u2009=\u2009.08) cognitive function than frequency-matched controls across time. At 5 years, however, women with breast cancer exposed to endocrine therapy and APOE4 carriers in particular exhibited lower learning and memory scores than other groups (P\u2009&amp;lt;\u2009.05). Our results suggest endocrine therapy may have long-term effects on cognitive function in women with breast cancer, particularly APOE4 carriers. Further characterization of genetic risk for long-term cognitive decline will be useful to inform survivorship care of older women.<\/jats:p>","DOI":"10.1093\/jncics\/pkag028","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:53:57Z","timestamp":1773806037000},"source":"Crossref","is-referenced-by-count":0,"title":["Interaction of endocrine therapy for breast cancer with APOE4 status on cognition over 5-year follow-up"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-930X","authenticated-orcid":false,"given":"Kathleen","family":"Van Dyk","sequence":"first","affiliation":[{"name":"Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles , Los Angeles, CA,","place":["United States"]},{"name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles , Los Angeles, CA,","place":["United States"]},{"name":"City of Hope , Duarte, CA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanting","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University , Washington, DC,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7936-2818","authenticated-orcid":false,"given":"Tim A","family":"Ahles","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center , New York, NY,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-6165","authenticated-orcid":false,"given":"James C","family":"Root","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center , New York, NY,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-4759","authenticated-orcid":false,"given":"Jaeil","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University , Washington, DC,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8811-566X","authenticated-orcid":false,"given":"Ashley L","family":"Artese","sequence":"additional","affiliation":[{"name":"Department of Exercise Science and Health Promotion, Charles E. Schmidt College of Science, Florida Atlantic University , Boca Raton, FL,","place":["United States"]},{"name":"Center for the Study of Aging and Human Development, Duke University Medical Center , Durham, NC,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-2078","authenticated-orcid":false,"given":"Traci N","family":"Bethea","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University , Washington, DC,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey J","family":"Cohen","sequence":"additional","affiliation":[{"name":"Center for the Study of Aging and Human Development, Duke University Medical Center , Durham, NC,","place":["United 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