{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:45:50Z","timestamp":1782578750195,"version":"3.54.5"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"publisher","award":["70116154"],"award-info":[{"award-number":["70116154"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) survival is improving, yet long-term survivors remain at risk for cancer- and treatment-related late effects, which may emerge many years after diagnosis and treatment. We aimed to summarize evidence on late effects and their risk factors reported \u22655\u2009years after CRC diagnosis, compared to cancer-free controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The literature search for this scoping review was conducted in PubMed, EMBASE, and Web of Science from inception to November 18, 2025. Primary research studies investigating late effects and providing relative risk estimates specifically \u22655\u2009years after diagnosis were included. Risk of bias was assessed with the Newcastle-Ottawa-Scale. The study was registered with Open Science Framework, 10.17605\/OSF.IO\/JY6DX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 9 observational studies that reported relative risk estimates for late effects. Seven studies had a low risk of bias and 2 were at moderate risk. The most frequently investigated late effect was incidence of diabetes (5 studies). The highest relative risks were reported for immunity disorders (5-10\u2009years hazard ratio [HR] = 4.56, 99% CI = 1.36 to 15.31), depression (&amp;gt;5\u2009years HR = 2.65, 95% CI =1.61 to 4.36), and nutritional deficiency (5-10\u2009years HR = 1.69, 99% CI = 1.38 to 2.08). Comorbidities at diagnosis, age at diagnosis, and treatment were the most common risk factors associated with late effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This scoping review found that even \u22655\u2009years after diagnosis late effects requiring treatment are considerably more common among CRC survivors than cancer-free controls. The small number of studies and the broad spectrum of identified late effects highlight the need for extensive research to characterize late effects to improve long-term survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag057","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:46:47Z","timestamp":1781178407000},"source":"Crossref","is-referenced-by-count":0,"title":["Late effects among colorectal cancer survivors \u22655 years after diagnosis\u2014a systematic scoping review"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-3363","authenticated-orcid":false,"given":"Toktam","family":"Pour","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology of Early Cancer Detection, German Cancer Research Center (DKFZ) , Heidelberg,","place":["Germany"]},{"name":"Unit of Cancer Survivorship Outcomes & Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg,","place":["Germany"]},{"name":"Medical Faculty, University of Heidelberg , Heidelberg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jose","family":"Urruchua Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology of Early Cancer Detection, German Cancer Research Center (DKFZ) , Heidelberg,","place":["Germany"]},{"name":"Medical Faculty, University of Heidelberg , Heidelberg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S Y","family":"Thong","sequence":"additional","affiliation":[{"name":"Unit of Cancer Survivorship Outcomes & Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-1572","authenticated-orcid":false,"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[{"name":"Cancer Prevention Graduate School, German Cancer Research Center (DKFZ) , Heidelberg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Arndt","sequence":"additional","affiliation":[{"name":"Unit of Cancer Survivorship Outcomes & Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-3197","authenticated-orcid":false,"given":"Michael","family":"Hoffmeister","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology of Early Cancer Detection, German Cancer Research Center (DKFZ) , Heidelberg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"2026062711512744300_pkag057-B1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2026062711512744300_pkag057-B2","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3322\/caac.21565","article-title":"Cancer treatment and survivorship statistics, 2019","volume":"69","author":"Miller","year":"2019","journal-title":"CA"},{"key":"2026062711512744300_pkag057-B3","author":"National Cancer Institute"},{"key":"2026062711512744300_pkag057-B4","doi-asserted-by":"publisher","DOI":"10.1002\/9781119013143","volume-title":"UICC Manual of Clinical Oncology","author":"Jones","year":"2015"},{"key":"2026062711512744300_pkag057-B5","doi-asserted-by":"publisher","first-page":"100458","DOI":"10.1016\/j.lanepe.2022.100458","article-title":"Overall and stage-specific survival of patients with screen-detected colorectal cancer in European countries: a population-based study in 9 countries","volume":"21","author":"Cardoso","year":"2022","journal-title":"Lancet Reg Health Eur"},{"key":"2026062711512744300_pkag057-B6","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/S0140-6736(22)00306-3","article-title":"Improved models of care for cancer survivors","volume":"399","author":"Jefford","year":"2022","journal-title":"Lancet"},{"key":"2026062711512744300_pkag057-B7","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1200\/OP-25-00248","article-title":"Oncology, primary care, and survivorship: time for onco-primary care?","volume":"21","author":"Oeffinger","year":"2025","journal-title":"JCO Oncol Pract"},{"key":"2026062711512744300_pkag057-B8","doi-asserted-by":"publisher","DOI":"10.17226\/11468","volume-title":"From Cancer Patient to Cancer Survivor: Lost in Transition","author":"Maria Hewitt","year":"2005"},{"key":"2026062711512744300_pkag057-B9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.6004\/jnccn.2009.0058","article-title":"The challenges of colorectal cancer survivorship","volume":"7","author":"Denlinger","year":"2009","journal-title":"J Natl Comprehensive Cancer Netw"},{"key":"2026062711512744300_pkag057-B10","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1056\/NEJMra1712502","article-title":"Cancer survivorship","volume":"379","author":"Shapiro","year":"2018","journal-title":"New England J Med"},{"key":"2026062711512744300_pkag057-B11","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2190\/PM.40.2.c","article-title":"It\u2019s not over when it\u2019s over: long-term symptoms in cancer survivors\u2014a systematic review","volume":"40","author":"Harrington","year":"2010","journal-title":"Int J Psychiatry Med"},{"key":"2026062711512744300_pkag057-B12","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s00520-009-0615-5","article-title":"What are the unmet supportive care needs of people with cancer? a systematic review","volume":"17","author":"Harrison","year":"2009","journal-title":"Support Care Cancer"},{"key":"2026062711512744300_pkag057-B13","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/S0140-6736(22)00242-2","article-title":"Management of common clinical problems experienced by survivors of cancer","volume":"399","author":"Emery","year":"2022","journal-title":"Lancet"},{"key":"2026062711512744300_pkag057-B14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/spc.0000000000000692","article-title":"Cancer survivor late-effects, chronic health problems after cancer treatment: what\u2019s the evidence from population and registry data and where are the gaps?","volume":"18","author":"Faithfull","year":"2024","journal-title":"Curr Opin Support Palliat Care"},{"key":"2026062711512744300_pkag057-B15","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/jnci\/djab049","article-title":"Evidence gaps in cancer survivorship care: a report from the 2019 National Cancer Institute Cancer Survivorship Workshop","volume":"113","author":"Gallicchio","year":"2021","journal-title":"J Natl Cancer Inst"},{"key":"2026062711512744300_pkag057-B16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nrclinonc.2016.199","article-title":"Surveillance after curative treatment for colorectal cancer","volume":"14","author":"van der Stok","year":"2017","journal-title":"Nat Rev Clin Oncol."},{"key":"2026062711512744300_pkag057-B17","doi-asserted-by":"publisher","first-page":"E132","DOI":"10.1097\/NCC.0000000000000785","article-title":"Symptom experiences in colorectal cancer survivors after cancer treatments: a systematic review and meta-analysis","volume":"43","author":"Han","year":"2020","journal-title":"Cancer Nurs"},{"key":"2026062711512744300_pkag057-B18","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s11864-019-0635-4","article-title":"Survivorship guidance for patients with colorectal cancer","volume":"20","author":"Simard","year":"2019","journal-title":"Curr Treat Options Oncol"},{"key":"2026062711512744300_pkag057-B19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/codi.16299","article-title":"Management of treatment-related sequelae following colorectal cancer","volume":"25","author":"Haas","year":"2023","journal-title":"Colorectal Dis"},{"key":"2026062711512744300_pkag057-B20","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1001\/jamaoncol.2018.0126","article-title":"Association of survival with adherence to the American Cancer Society nutrition and physical activity guidelines for cancer survivors after colon cancer diagnosis: the CALGB 89803\/Alliance trial","volume":"4","author":"Blarigan","year":"2018","journal-title":"JAMA Oncol"},{"key":"2026062711512744300_pkag057-B21","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s41571-021-00580-3","article-title":"Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care","volume":"19","author":"Carroll","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"2026062711512744300_pkag057-B22","doi-asserted-by":"publisher","first-page":"e70929","DOI":"10.1002\/cam4.70929","article-title":"Accelerated aging in cancer and cancer treatment: current status of biomarkers","volume":"14","author":"Abraham","year":"2025","journal-title":"Cancer Med"},{"key":"2026062711512744300_pkag057-B23","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/s41574-025-01159-z","article-title":"Early-onset colorectal cancer as an emerging disease of metabolic dysregulation","volume":"21","author":"Du","year":"2025","journal-title":"Nat Rev Endocrinol"},{"key":"2026062711512744300_pkag057-B24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S1470-2045(24)00600-4","article-title":"Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data","volume":"26","author":"Sung","year":"2025","journal-title":"Lancet Oncol"},{"key":"2026062711512744300_pkag057-B25","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.3748\/wjg.v29.i8.1289","article-title":"Early-onset colorectal cancer: a review of current knowledge","volume":"29","author":"Saraiva","year":"2023","journal-title":"World J Gastroenterol"},{"key":"2026062711512744300_pkag057-B26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"2026062711512744300_pkag057-B27","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1002\/cncr.35133","article-title":"Diabetes mellitus in long-term survivors with colorectal, breast, or prostate cancer: prevalence and prognosis. A population-based study","volume":"130","author":"Yang","year":"2024","journal-title":"Cancer"},{"key":"2026062711512744300_pkag057-B28","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1186\/s12885-023-11329-9","article-title":"The risk of acute kidney injury in colorectal cancer survivors: an English population-based matched cohort study","volume":"23","author":"Andresen","year":"2023","journal-title":"BMC Cancer"},{"key":"2026062711512744300_pkag057-B29","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.6004\/jnccn.2022.7042","article-title":"Incident cardiovascular diseases among survivors of high-risk stage II\u2013III colorectal cancer: a cluster-wide cohort study","volume":"20","author":"Lee","year":"2022","journal-title":"J Natl Compr Cancer Netw."},{"key":"2026062711512744300_pkag057-B30","doi-asserted-by":"publisher","first-page":"104345","DOI":"10.1016\/j.ebiom.2022.104345","article-title":"New onset of type 2 diabetes after colorectal cancer diagnosis: results from three prospective US cohort studies, systematic review, and meta-analysis","volume":"86","author":"Zeng","year":"2022","journal-title":"eBioMedicine"},{"key":"2026062711512744300_pkag057-B31","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081979","article-title":"Risk of pharmacological or hospital treatment for depression in patients with colorectal cancer\u2013associations with pre-cancer lifestyle, comorbidity and clinical factors","volume":"13","author":"Kjaer","year":"2021","journal-title":"Cancers"},{"key":"2026062711512744300_pkag057-B32","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/jnci\/djz040","article-title":"Endocrine and metabolic diseases among colorectal cancer survivors in a population-based cohort","volume":"112","author":"Hawkins","year":"2020","journal-title":"J Natl Cancer Inst."},{"key":"2026062711512744300_pkag057-B33","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1016\/j.ijrobp.2018.02.083","article-title":"Mental health disorders are more common in colorectal cancer survivors and associated with decreased overall survival","volume":"101","author":"Lloyd","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026062711512744300_pkag057-B34","doi-asserted-by":"publisher","first-page":"djv402","DOI":"10.1093\/jnci\/djv402","article-title":"Incidence of diabetes in colorectal cancer survivors","volume":"108","author":"Singh","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"2026062711512744300_pkag057-B35","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1038\/bjc.2011.420","article-title":"Long-term health outcomes in a British cohort of breast, colorectal and prostate cancer survivors: a database study","volume":"105(Suppl 1)","author":"Khan","year":"2011","journal-title":"Br J Cancer"},{"key":"2026062711512744300_pkag057-B36","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S1470-2045(13)70244-4","article-title":"Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: a systematic review and meta-analysis","volume":"14","author":"Mitchell","year":"2013","journal-title":"Lancet Oncol"},{"key":"2026062711512744300_pkag057-B37","doi-asserted-by":"publisher","first-page":"102826","DOI":"10.1016\/j.eclinm.2024.102826","article-title":"Early, medium and long-term mental health in cancer survivors compared with cancer-free comparators: matched cohort study using linked UK electronic health records","volume":"76","author":"Forbes","year":"2024","journal-title":"EClinicalMedicine"},{"key":"2026062711512744300_pkag057-B38","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.mcna.2017.06.005","article-title":"Anxiety and depression in cancer survivors","volume":"101","author":"Yi","year":"2017","journal-title":"Med Clin North Am"},{"key":"2026062711512744300_pkag057-B39","doi-asserted-by":"publisher","first-page":"e13086","DOI":"10.1111\/ecc.13086","article-title":"A systematic review on the prevalence of symptoms of depression, anxiety and distress in long-term cancer survivors: implications for primary care","volume":"28","author":"Brandenbarg","year":"2019","journal-title":"Eur J Cancer Care"},{"key":"2026062711512744300_pkag057-B40","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00761-021-00924-9","article-title":"Psychische Sp\u00e4t- und Langzeitfolgen einer Krebserkrankung","volume":"27","author":"G\u00f6tze","year":"2021","journal-title":"Onkologe"},{"key":"2026062711512744300_pkag057-B41","doi-asserted-by":"publisher","first-page":"e100871","DOI":"10.1136\/gpsych-2022-100871","article-title":"Cancer-related psychosocial challenges","volume":"35","author":"Wang","year":"2022","journal-title":"Gen Psychiatr"},{"key":"2026062711512744300_pkag057-B42","doi-asserted-by":"publisher","first-page":"102942","DOI":"10.1016\/j.eclinm.2024.102942","article-title":"Global unmet psychosocial needs in cancer care: health policy","volume":"78","author":"Bergerot","year":"2024","journal-title":"eClinicalMedicine"},{"key":"2026062711512744300_pkag057-B43","doi-asserted-by":"publisher","first-page":"227","DOI":"10.4239\/wjd.v11.i6.227","article-title":"Diabetes and cancer: epidemiological and biological links","volume":"11","author":"Wang","year":"2020","journal-title":"World J Diabetes"},{"key":"2026062711512744300_pkag057-B44","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7120484","article-title":"Association between cardiovascular risk and diabetes with colorectal neoplasia: a site-specific analysis","volume":"7","author":"Niederseer","year":"2018","journal-title":"J Clin Med"},{"key":"2026062711512744300_pkag057-B45","doi-asserted-by":"publisher","first-page":"108751","DOI":"10.1016\/j.diabres.2021.108751","article-title":"Incidence and disease course of new-onset diabetes mellitus in breast and colorectal cancer patients undergoing chemotherapy: a prospective multicenter cohort study","volume":"174","author":"Lee","year":"2021","journal-title":"Diabetes Res Clin Pract"},{"key":"2026062711512744300_pkag057-B46","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1001\/jamaoncol.2018.1684","article-title":"Incidence of diabetes after cancer development. A Korean national cohort study","volume":"4","author":"Hwangbo","year":"2018","journal-title":"JAMA Oncol."},{"key":"2026062711512744300_pkag057-B47","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1158\/1055-9965.EPI-25-0037","article-title":"The risk of type 2 diabetes among older Asian, Native Hawaiian, and Pacific Islander colorectal cancer survivors: a population-based study using the SEER-Medicare database","volume":"34","author":"Liu","year":"2025","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2026062711512744300_pkag057-B48","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41568-021-00347-z","article-title":"Systemic immunity in cancer","volume":"21","author":"Hiam-Galvez","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"2026062711512744300_pkag057-B49","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1001\/jama.294.20.2587","article-title":"Risk of pelvic fractures in older women following pelvic irradiation","volume":"294","author":"Baxter","year":"2005","journal-title":"JAMA"},{"key":"2026062711512744300_pkag057-B50","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1002\/cam4.2030","article-title":"Increased risk of pelvic fracture after radiotherapy in rectal cancer survivors: a propensity matched study","volume":"8","author":"Kang","year":"2019","journal-title":"Cancer Med"},{"key":"2026062711512744300_pkag057-B51","doi-asserted-by":"publisher","first-page":"e66839","DOI":"10.7759\/cureus.66839","article-title":"A comprehensive narrative review of the impact of pelvic radiotherapy on pelvic bone health: pathophysiology, early diagnosis, and prevention strategies","volume":"16","author":"Elgendy","year":"2024","journal-title":"Cureus"},{"key":"2026062711512744300_pkag057-B52","doi-asserted-by":"publisher","first-page":"47","DOI":"10.4137\/CMC.S19704","article-title":"Getting to the heart of the matter: an overview of cardiac toxicity related to cancer therapy","volume":"9","author":"Hamo","year":"2015","journal-title":"Clin Med Insights Cardiol"},{"key":"2026062711512744300_pkag057-B53","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1200\/JCO.2017.74.9739","article-title":"New-onset cardiovascular morbidity in older adults with stage I to III colorectal cancer","volume":"36","author":"Kenzik","year":"2018","journal-title":"J Clin Oncol"},{"key":"2026062711512744300_pkag057-B54","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jacc.2022.04.042","article-title":"Cardiovascular disease risk among cancer survivors: the Atherosclerosis Risk in Communities (ARIC) study","volume":"80","author":"Florido","year":"2022","journal-title":"J Am College Cardiol"},{"key":"2026062711512744300_pkag057-B55","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1200\/JCO.2015.64.0409","article-title":"Cardiovascular disease among survivors of adult-onset cancer: a community-based retrospective cohort study","volume":"34","author":"Armenian","year":"2016","journal-title":"JCO"},{"key":"2026062711512744300_pkag057-B56","doi-asserted-by":"publisher","first-page":"721107","DOI":"10.3389\/fcvm.2021.721107","article-title":"Estimating risk of cardiovascular disease among long-term colorectal cancer survivors: a nationwide cohort study","volume":"8","author":"Jeong","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2026062711512744300_pkag057-B57","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1002\/bjs.5525","article-title":"Late adverse effects of short-course preoperative radiotherapy in rectal cancer","volume":"93","author":"Pollack","year":"2006","journal-title":"Br J Surg"},{"key":"2026062711512744300_pkag057-B58","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1093\/jnci\/djaf243","article-title":"Cardiovascular risk in long-term survivors of breast, prostate, colon, and rectal cancer","volume":"118","author":"Westvold","year":"2026","journal-title":"J Natl Cancer Inst"},{"key":"2026062711512744300_pkag057-B59","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/s41569-020-0348-1","article-title":"Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia","volume":"17","author":"Herrmann","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2026062711512744300_pkag057-B60","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s10741-025-10531-0","article-title":"Cancer therapy-induced cardiotoxicity: mechanisms and mitigations","volume":"30","author":"Shil","year":"2025","journal-title":"Heart Fail Rev"},{"key":"2026062711512744300_pkag057-B61","doi-asserted-by":"publisher","first-page":"1629675","DOI":"10.3389\/fendo.2025.1629675","article-title":"Cardiovascular-kidney-metabolic comorbidities in colorectal cancer survivors: a nationwide cohort study on the role of metabolic syndrome","volume":"16","author":"Liu","year":"2025","journal-title":"Front Endocrinol"},{"key":"2026062711512744300_pkag057-B62","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1038\/s41467-023-37231-3","article-title":"Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers","volume":"14","author":"Chang","year":"2023","journal-title":"Nat Commun"},{"key":"2026062711512744300_pkag057-B63","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1001\/jamaoncol.2018.7192","article-title":"Long-term somatic disease risk in adult Danish cancer survivors","volume":"5","author":"Kjaer","year":"2019","journal-title":"JAMA Oncol"},{"key":"2026062711512744300_pkag057-B64","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s11764-021-01102-x","article-title":"Future research in cancer survivorship","volume":"15","author":"Chan","year":"2021","journal-title":"J Cancer Surviv"},{"key":"2026062711512744300_pkag057-B65","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3322\/caac.21286","article-title":"American Cancer Society Colorectal Cancer Survivorship Care Guidelines","volume":"65","author":"El-Shami","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"2026062711512744300_pkag057-B66","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/j.annonc.2020.06.022","article-title":"Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"31","author":"Argil\u00e9s","year":"2020","journal-title":"Ann Oncol"},{"key":"2026062711512744300_pkag057-B67","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.annonc.2025.05.528","article-title":"Localised rectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"36","author":"Hofheinz","year":"2025","journal-title":"Ann Oncol"},{"key":"2026062711512744300_pkag057-B68","author":"National Comprehensive Cancer Network (NCCN)","year":"2024"}],"container-title":["JNCI Cancer Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jncics\/advance-article-pdf\/doi\/10.1093\/jncics\/pkag057\/68520391\/pkag057.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jncics\/article-pdf\/10\/3\/pkag057\/68520391\/pkag057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jncics\/article-pdf\/10\/3\/pkag057\/68520391\/pkag057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:51:37Z","timestamp":1782575497000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jncics\/article\/doi\/10.1093\/jncics\/pkag057\/8707342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5,9]]}},"URL":"https:\/\/doi.org\/10.1093\/jncics\/pkag057","relation":{},"ISSN":["2515-5091"],"issn-type":[{"value":"2515-5091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,5,9]]},"article-number":"pkag057"}}