{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:36Z","timestamp":1792785996516,"version":"4.5.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["GNT1163120"],"award-info":[{"award-number":["GNT1163120"]}],"id":[{"id":"https:\/\/ror.org\/011kf5r70","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Pooling Project of Prospective Studies of Diet and Cancer"},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["GNT1163120"],"award-info":[{"award-number":["GNT1163120"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AAA R01AA024770"],"award-info":[{"award-number":["AAA R01AA024770"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["GNT1163120"],"award-info":[{"award-number":["GNT1163120"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stomach cancer presents complex etiological heterogeneity. Ethanol in alcoholic beverages and its metabolite acetaldehyde are carcinogens causally linked to several cancers, but their role in gastric carcinogenesis has not been established. We analyzed harmonized, individual-level prospective data to examine associations between alcohol intake and risk of stomach cancer and its subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 2\u2009009\u2009951 participants in 20 cohorts (mean follow-up\u2009=\u20099 to 29\u2009years) within the Pooling Project of Prospective Studies of Diet and Cancer (n\u2009=\u20098357 incident invasive gastric adenocarcinomas) were included. We used Cox regression to assess associations between alcohol intake and risk of stomach cancer overall and by anatomical and histological subtype and population subgroup, adjusting for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Evidence for an association between alcohol intake and overall stomach cancer risk was weak (hazard ratio, HR, for \u226530 vs 0.1-&amp;lt;5\u2009g\/day: 1.06 [95% confidence interval, CI = 0.96 to 1.16], Pbetween-studies heterogeneity = .43). Positive associations with stomach cancer risk were observed in never smokers (HR, for \u226530 vs 0.1-&amp;lt;5\u2009g\/day: 1.20 [95% CI = 1.02 to 1.42]; Pinteraction = .02) and for Asian studies (HR, 1.21 [95% CI = 1.02 to 1.42]; Pinteraction = .01). Modest increased risks were observed for noncardia cancers such as those of the fundus, body, and greater curvature, but not distally located noncardia cancers. HRs did not differ materially between diffuse- and intestinal-type cancers (Pheterogeneity &amp;gt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was little evidence of an overall association between alcohol intake and stomach cancer risk, although modest positive associations were observed among never smokers and in Asian<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag073","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:44:53Z","timestamp":1784893493000},"source":"Crossref","is-referenced-by-count":0,"title":["Alcohol intake and risk of stomach cancer: a pooled analysis of 20 cohorts"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-0183","authenticated-orcid":false,"given":"Harindra","family":"Jayasekara","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria , Melbourne, Victoria,","place":["Australia"]},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne , Melbourne, Victoria,","place":["Australia"]},{"name":"School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University , Clayton, Victoria,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1951-8961","authenticated-orcid":false,"given":"Molin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]},{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, MA,","place":["United States"]},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Peng","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Division, Cancer Council Victoria , Melbourne, Victoria,","place":["Australia"]},{"name":"School of Public Health, The University of Queensland , Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Prevention, National Cancer Center Institute for Cancer Control , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C","family":"Abnet","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Rockville, MD,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine , Nashville, TN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T","family":"Chan","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA,","place":["United States"]},{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mridul","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition, Iowa State University , Ames, IA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-6609","authenticated-orcid":false,"given":"A Heather","family":"Eliassen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard T.H. 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