{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:47:00Z","timestamp":1786117620862,"version":"build-2736575974"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and Objectives<\/jats:title>\n                    <jats:p>This project elucidates the pivotal scientific discoveries that culminated in the isolation of luteinizing hormone-releasing hormone (LHRH). It details the contributions of scientists Andrew Schally and Roger Guillemin, whose competitive biochemical research led to the Nobel Prize in 1977.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This project entails a comprehensive review of the pivotal scientific developments that culminated in the discovery of LHRH, examined through the historical lens. The sources included peer-reviewed articles, Nobel lectures, and oral history transcripts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Harris first showed the anterior pituitary\u2019s regulation by the hypothalamus in 1937, establishing the principles for Schally and Guillemin. Schally and Guillemin independently isolated TRF in 1969, requiring 160\u200a000 porcine hypothalami for purification. Both then pursued LHRH, isolating it independently in 1971 using 240\u200a000 porcine brains and developing advanced biochemical techniques. These methods have enabled LHRH analog synthesis for prostate cancer research. In 1971, Schally demonstrated that LHRH could suppress gonadotropin secretion. Synthetic LHRH infusion in monkeys showed LHRH\u2019s ability to desensitize pituitary gonadotropin-releasing hormone receptors. This discovery enabled the use of LHRH analog treatments for hormone-sensitive conditions. Schally conducted the first clinical trials in Mexico in 1972 and organized the first LHRH agonist study for prostate cancer, which was published in 1982.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The discovery of LHRH represents a landmark convergence of evolving physiological concepts, rigorous biochemical innovation, and impactful clinical translation, leading to the Nobel Prize. The rivalry between Schally and Guillemin led to foundational discoveries that transformed the management of androgen-dependent malignancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag075","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:59:26Z","timestamp":1783684766000},"source":"Crossref","is-referenced-by-count":0,"title":["Luteinizing hormone-releasing hormone in prostate cancer treatment: from hypothalamic discovery to clinical translation"],"prefix":"10.1093","volume":"10","author":[{"given":"Samuel","family":"Benisti","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Montreal , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM) , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guila","family":"Delouya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-3213","authenticated-orcid":false,"given":"Daniel","family":"Taussky","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al , Montreal, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"2026080610140110700_pkag075-B1","first-page":"145","article-title":"Current status of luteinizing hormone-releasing hormone in diagnosis and treatment of disorders in reproductive 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