{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T21:22:40Z","timestamp":1787433760585,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1143502C"],"award-info":[{"award-number":["TCVGH-1143502C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite effective antiretroviral therapy, people living with human immunodeficiency virus (HIV) (PLWH) remain at a higher risk of developing Hodgkin lymphoma (HL). Further, survival disparities persist despite similar treatment recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Herein, we present a global retrospective cohort study including data of adults (\u226518\u2009years) diagnosed with HL between 2015 and 2025 from the TriNetX database to evaluate the survival outcomes of Hodgkin lymphoma in HIV-infected vs non-HIV-infected patients and analyze the associated risk factors. Patients were stratified according to HIV status and matched 1:1 for age, sex, race, and comorbidities. Overall survival (OS) was analyzed using Kaplan-Meier and Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 927 matched HIV-infected and non-HIV-infected patients were included. Overall, HIV-positive status was associated with significantly inferior OS (HR 1.42; 95% CI 1.10-1.84; P\u2009=\u2009.033). Among PLWH, cerebrovascular disease, hepatitis C virus infection, and chronic kidney disease independently predicted increased mortality. In a matched subgroup of patients treated with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy (n\u2009=\u2009154 per group), OS did not differ significantly between the HIV-positive and HIV-negative groups (HR 1.37; 95% CI 0.73-2.56; P\u2009=\u2009.247).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, HIV-infected patients with HL experienced worse OS compared with non-HIV-infected individuals, but the outcomes were comparable when treated with ABVD chemotherapy, highlighting the importance of optimal treatment delivery and comorbidity management in PLWH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag076","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:53:08Z","timestamp":1786535588000},"source":"Crossref","is-referenced-by-count":0,"title":["HIV infection and survival in Hodgkin lymphoma: a real-world analysis of a multicenter research network"],"prefix":"10.1093","volume":"10","author":[{"given":"Shih-Ping","family":"Lin","sequence":"first","affiliation":[{"name":"Department of internal medicine, Taichung Veterans General Hospital , Taichung,","place":["Taiwan"]},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University , Taichung,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Han","family":"Yen","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Taichung Veterans General Hospital , Taichung,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4626-9369","authenticated-orcid":false,"given":"Jian-Ri","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Taichung Veterans General Hospital , Taichung,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1801-4964","authenticated-orcid":false,"given":"Cheng-Wei","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University , Taichung,","place":["Taiwan"]},{"name":"Division of Medical Oncology, Department of Oncology, Taichung Veterans General Hospital , Taichung,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026082216564327000_pkag076-B1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/hiv.12322","article-title":"Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons","volume":"17","author":"Ryom","year":"2016","journal-title":"HIV 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