{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:49:12Z","timestamp":1791575352471,"version":"4.3.4"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute National Community Oncology Research Program","award":["UG1CA189961"],"award-info":[{"award-number":["UG1CA189961"]}]},{"name":"National Cancer Institute National Community Oncology Research Program","award":["R01CA177592"],"award-info":[{"award-number":["R01CA177592"]}]},{"name":"National Cancer Institute National Community Oncology Research Program","award":["K24AG056589"],"award-info":[{"award-number":["K24AG056589"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Cancer-related cognitive impairment is common in patients receiving cancer treatment but may be underdetected by clinician-graded adverse events (AEs) alone. Patient-reported outcomes and cognitive screening may improve identification of cognitive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of the nationwide, multicenter GAP70+ trial of adults aged \u226570\u2009years with advanced cancer starting systemic therapy. Cognitive symptoms were assessed longitudinally using patient-reported and clinician-graded cognitive AEs, and Mini-Cog screening at baseline, 4-6\u2009weeks, 3\u2009months, and 6\u2009months. We examined prevalence, longitudinal trajectories, and associations with Mini-Cog impairment. Statistical significance was set at 2-sided P\u2009&amp;lt;\u2009.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 704 participants (mean age = 77.2\u2009years; range = 70-96\u2009years), patient-reported cognitive AEs were more prevalent than clinician-graded cognitive AEs at all time points: 19% vs 0.48% at 4-6\u2009weeks, 18% vs 2.5% at 3\u2009months, and 22% vs 0.44% at 6\u2009months (all P\u2009&amp;lt;\u2009.001). Patient-reported cognitive AEs also fluctuated within patients over time. Impaired Mini-Cog was associated with higher patient-reported cognitive AEs at all post-baseline time points: 31% vs 15% at 4-6\u2009weeks, 34% vs 14% at 3\u2009months, and 49% vs 15% at 6\u2009months (all P\u2009&amp;lt;\u2009.001). In contrast, associations with clinician-graded cognitive AEs were observed only at 3\u2009months (P\u2009=\u2009.004) and 6\u2009months (P\u2009=\u2009.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cognitive symptomatic AEs are common and often underdetected by clinician grading alone in older adults with advanced cancer. Combining patient-reported AEs with brief cognitive screening may improve detection during treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag086","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:50:22Z","timestamp":1787226622000},"source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of patient-reported and clinician-graded cognitive symptomatic adverse events in older patients with advanced cancer"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7731-6298","authenticated-orcid":false,"given":"Riham","family":"Alieldin","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Supportive Care in Cancer, University of Rochester , Rochester, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, 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