{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:47:38Z","timestamp":1791928058078,"version":"4.3.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients diagnosed with breast cancer are at increased risk of multiple common diseases; however, the spectrum of these diseases and the contribution of inherited genetic susceptibility remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated 15 common diseases and tested their associations with breast cancer exposure and disease-specific polygenic risk scores in the UK Biobank (n\u2009=\u2009254\u2009736). Analyses were performed using cause-specific Cox proportional hazards models within a full-cohort framework, with time-updated breast cancer status, delayed entry at study recruitment, and age as the underlying time scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After recruitment, incident breast cancer was diagnosed in 11\u2009386 women (4.47%), including 2742 (24.08%) with metastatic breast cancer. Patients with breast cancer had an increased risk of 9 diseases spanning cardiovascular, metabolic, and neuropsychiatric domains (P\u2009&amp;lt;\u2009.003, Bonferroni corrected). Elevated risks were generally observed among patients with both early-stage and advanced breast cancer. Inherited susceptibility further stratified disease risk, with the highest risks observed among patients with breast cancer and elevated disease-specific polygenic risk scores. For example, compared with women without breast cancer, the hazard ratio for osteoporosis was 2.33 (95% CI = 2.15 to 2.52) among women with any breast cancer, 2.38 (95% CI = 2.18 to 2.59) among women with nonmetastatic breast cancer, and 2.12 (95% CI = 1.78 to 2.54) among women with metastatic breast cancer; the hazard ratio was 4.48 (95% CI = 3.99 to 5.02) among patients with breast cancer in the highest quartile of osteoporosis-specific polygenic risk scores (all P\u2009&amp;lt;\u2009.001). In contrast, breast cancer was not statistically significantly associated with risk of coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Breast cancer and inherited genetic susceptibility jointly contribute to increased risk of multiple common diseases, supporting the integration of genetic risk stratification into survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag089","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:15:28Z","timestamp":1788520528000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic risk stratification of common diseases in breast cancer survivors: a population-based cohort study"],"prefix":"10.1093","volume":"10","author":[{"given":"Annabelle","family":"Ashworth","sequence":"first","affiliation":[{"name":"Program for Genomic Translational Research , Endeavor Health, Evanston, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqing","family":"Shi","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research , Endeavor Health, Evanston, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy","family":"Tran","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research , Endeavor Health, Evanston, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research , Endeavor Health, Evanston, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley J","family":"Mulford","sequence":"additional","affiliation":[{"name":"Genomic Health Initiative , Endeavor Health, Evanston, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqun Lilly","family":"Zheng","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research , Endeavor Health, Evanston, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Duggan","sequence":"additional","affiliation":[{"name":"Translational Genomics Research Institute, Part of City of Hope , Phoenix, AZ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T","family":"Helfand","sequence":"additional","affiliation":[{"name":"Program for Genomic Translational Research , Endeavor Health, Evanston, IL,","place":["United States"]},{"name":"University of Chicago Pritzker School of Medicine , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R","family":"Sanders","sequence":"additional","affiliation":[{"name":"Genomic Health Initiative , Endeavor Health, Evanston, IL,","place":["United States"]},{"name":"University of Chicago Pritzker School of Medicine , Chicago, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Azam","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Endeavor Health Cardiovascular Institute , Evanston, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Brockstein","sequence":"additional","affiliation":[{"name":"Kellogg Cancer Center , Endeavor Health, Evanston, IL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"DePersia","sequence":"additional","affiliation":[{"name":"Mark R. 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