{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:55:09Z","timestamp":1791582909980,"version":"4.3.4"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA265729"],"award-info":[{"award-number":["U01CA265729"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U24CA272897"],"award-info":[{"award-number":["U24CA272897"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32DK083256"],"award-info":[{"award-number":["T32DK083256"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite the frequent late-stage diagnosis of gastric cancer (GC), the United States lacks a routine GC screening program. Liquid biopsy (LB), specifically blood-based tests, has emerged as a potential screening approach, but it is unclear whether such a strategy is cost-effective. We, therefore, evaluated the cost-effectiveness of LB screening for GC in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Markov model was developed to compare no screening (current standard-of-care) and 2 LB-screening strategies. The study used a simulated cohort of 45-year-old individuals with average risk of GC. Primary model outcomes included life expectancy, quality-adjusted life-years (QALYs), total cost, and incremental cost-effectiveness ratios (ICERs). A strategy was considered cost-effective if the ICER was\u2009&amp;lt;\u2009the US willingness-to-pay threshold of $100\u00a0000 per quality-adjusted-life-year gained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the base-case analysis, LB screening strategies were not cost-effective, with an ICER of $917\u00a0826 per QALY gained. Screening became cost-effective for high-risk subpopulations or when the per-test cost was approximately $89.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This economic evaluation of LB for GC screening found that while LB strategies are effective in reducing cancer incidence and mortality, they are not cost-effective due to high test costs. Our findings could help inform the potential planning of future clinical validation studies for LB tests used for GC screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag090","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T11:20:36Z","timestamp":1788693636000},"source":"Crossref","is-referenced-by-count":0,"title":["Cost-effectiveness of liquid biopsy screening for gastric cancer in the United States"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-8566","authenticated-orcid":false,"given":"Jeong Yun","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine , New York, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Agyekum","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Irving Medical 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