{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:37Z","timestamp":1792785997010,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21 CA283132"],"award-info":[{"award-number":["R21 CA283132"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K22 CA297064"],"award-info":[{"award-number":["K22 CA297064"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Virginia Precision Health Initiative","id":[{"id":"https:\/\/ror.org\/0153tk833","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ultra-processed food (UPF) intake is associated with colorectal cancer (CRC) risk and may contribute to rising early-onset CRC incidence, although underlying mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined associations between UPF intake and accelerated epigenetic aging (AgeAccel) in normal colorectal tissues among 106 participants (73 African American (AA); 33 European American) in the Cleveland Colon Screening and Risk Factors Study (2012-2018). Ultra-processed food intake was assessed using a Food Frequency Questionnaire and classified according to the NOVA system. AgeAccel was derived from DNA methylation assays of colorectal biopsies. Linear mixed-effects regression models adjusted for energy intake, race, and colorectal location assessed associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher UPF intake was significantly associated with increased AgeAccel in overall colorectum (P\u2009=\u20096.87\u2009\u00d7\u200910\u221203; \u03b2\u2009=\u2009.061; SE = 0.028), corresponding to a\u2009+\u20091.41-year difference between the highest and lowest quartiles. Associations were significant in the right colon and among AA participants (P\u2009&amp;lt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest a potential mechanistic link between UPF intake and CRC risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag092","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:52:43Z","timestamp":1788616363000},"source":"Crossref","is-referenced-by-count":0,"title":["Intake of ultra-processed foods and accelerated epigenetic aging of colorectal tissues"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-4397","authenticated-orcid":false,"given":"Matthew A","family":"Devall","sequence":"first","affiliation":[{"name":"Department of Family Medicine, University of Virginia , Charlottesville, VA,","place":["United 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