{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:49:21Z","timestamp":1791575361953,"version":"4.3.4"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Region Stockholm","award":["FoUI-1025616"],"award-info":[{"award-number":["FoUI-1025616"]}],"id":[{"id":"https:\/\/ror.org\/02zrae794","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early-onset colorectal cancer (EOCRC; age &amp;lt;50\u2009years) has increased in high-income countries. We updated a nationwide Swedish cohort study with data from 2020 to 2024 to compare recent trends with those reported during 1993-2019. Using the National Cancer Register, we identified all incident EOCRC at ages 20-49\u2009years. Temporal trends in age-standardized incidence were assessed using segmented Poisson regression with a breakpoint at 2020 to estimate annual percentage changes (APCs). A total of 1616 EOCRC cases were diagnosed during 2020-2024. Annual percentage changes for left-sided colon and rectal cancers were consistent with continued increases in incidence. In contrast, right-sided colon cancer showed a significant change in trend (P\u2009=\u2009.01), with a nonsignificant decline during 2020-2024 (APC \u22123.48, 95% CI = \u22127.88 to 1.14). These findings indicate that the continued rise in EOCRC is primarily driven by distal tumors, that is, left-sided colon and rectal cancers. Continued surveillance is needed to clarify long-term patterns and underlying drivers.<\/jats:p>","DOI":"10.1093\/jncics\/pkag097","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:11:00Z","timestamp":1789989060000},"source":"Crossref","is-referenced-by-count":0,"title":["Early-onset colorectal cancer in Sweden: increase in distal tumors but a shift in right-sided incidence, 2020-2024"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4558-5325","authenticated-orcid":false,"given":"Shabane","family":"Barot","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Education, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Department of Oncology, S\u00f6dersjukhuset , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-1537","authenticated-orcid":false,"given":"Cecilia","family":"Radkiewicz","sequence":"additional","affiliation":[{"name":"Clinical Pharmacoepidemiology, Clinical Epidemiology Unit, Department of Medicine, Solna, Karolinska Institutet , Stockholm,","place":["Sweden"]},{"name":"Department of Surgery and Oncology, Capio Sankt G\u00f6rans Hospital , Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2026100914522417900_pkag097-B1","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/S1470-2045(21)00199-6","article-title":"Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based 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