{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:39:55Z","timestamp":1792795195725,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cervical cancer remains a leading cause of morbidity and mortality among women in Uzbekistan, exceeding WHO elimination targets. Despite a school-based HPV vaccination program launched in 2019, screening coverage remains low, leading to delayed diagnoses; we examined cervical cancer trends in Tashkent (2014-2024) to evaluate the impact of the Korea Foundation for International Healthcare (KOFIH) screening project and UNFPA\/UNDP HPV testing initiatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed Tashkent City Oncoregister data for women diagnosed with invasive cervical cancer or carcinoma in situ (CIS) between 2014 and 2024 (n\u2009=\u20092140) after data cleaning. We calculated age-standardized incidence and mortality rates, assessed survival using Kaplan-Meier methods, and identified mortality predictors using Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The age-standardized incidence of invasive cervical cancer was 14.9 per 100\u00a0000. After KOFIH and UNFPA\/UNDP implementation, CIS diagnoses increased 3.4-fold (0.2-4.7 per 100\u00a0000), while the proportion of advanced-stage (III-IV) disease declined by 43%. Five-year survival showed clear stage dependence, ranging from 91.5% for CIS to 27.8% for stage IV. Age and stage were independent predictors of mortality. Crude mortality declined from 10.2 to 1.1 per 100\u00a0000 from 2014 to 2024, and case fatality decreased from 48.6% (2014-2019) to 27.2% (2020-2024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Organized screening through KOFIH and UNFPA initiatives can improve early detection and reduce mortality. However, 76.6% of staged invasive cases remain advanced (II-IV), and more than 80% of women have never been screened, underscoring the need to expand screening, sustain HPV vaccination, and strengthen prevention programs in Central Asia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag107","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:36:49Z","timestamp":1791286609000},"source":"Crossref","is-referenced-by-count":0,"title":["Population-based registry analysis of cervical cancer trends in Tashkent, Uzbekistan 2014-2024"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2986-5660","authenticated-orcid":false,"given":"Ulugbek Khudayberdievich","family":"Mirzaev","sequence":"first","affiliation":[{"name":"Department of Microbiology and Antimicrobial Resistance, National Biopharmaceutical Research Institute , Tashkent, Uzbekistan"},{"name":"Department of Life Sciences, Pharmaceutical Technical University , Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2061-4330","authenticated-orcid":false,"given":"Jasur Ravshanovich","family":"Juraev","sequence":"additional","affiliation":[{"name":"Department of Preventive Service, Kyoto University , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iroda Pulatovna","family":"Sharipova","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Pharmaceutical Technical University , Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8009-3291","authenticated-orcid":false,"given":"Sarvar Temurovich","family":"Islomov","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, National Children\u2019s Medical Center , Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nodira Isroilovna","family":"Tursunova","sequence":"additional","affiliation":[{"name":"Department of Oncology, Tashkent State Medical University , Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitora","family":"Rakhmatova","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Pharmaceutical Technical University , Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Shokir Qizi","family":"Shodieva","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Antimicrobial Resistance, National Biopharmaceutical Research Institute , Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9036-2744","authenticated-orcid":false,"given":"Mirzarakhim Mirzakhakimovich","family":"Baynazarov","sequence":"additional","affiliation":[{"name":"Department of Treatment Management, Ministry of Health of Uzbekistan , Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9649-7449","authenticated-orcid":false,"given":"Khasanjon Kobiljon Ugli","family":"Odilov","sequence":"additional","affiliation":[{"name":"Department Strategic Planning, Ministry of Health of Uzbekistan , Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilbar Yuldashevna","family":"Yuldasheva","sequence":"additional","affiliation":[{"name":"Tashkent City Branch of Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology, Oncologic Gynecology , Tashkent, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golib Abdulloyevich","family":"Khakimov","sequence":"additional","affiliation":[{"name":"Tashkent City Branch of Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology, Oncologic Gynecology , Tashkent, 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