{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:43:39Z","timestamp":1792568619833,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We sought to evaluate the associations of post-diagnostic consumption of flavonoids and flavonoid-rich foods with survival among patients with stage III colon cancer enrolled in a clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective observational study of 1625 patients with stage III colon cancer enrolled in the CALGB\/SWOG 80702 (Alliance) randomized adjuvant chemotherapy trial who completed a self-reported food frequency questionnaire within 6 weeks of and again 14-16 months post-randomization. Intakes of flavonoids overall and by subclasses (anthocyanidins, flavanones, flavan-3-ols, flavones, flavonols, isoflavones) were computed by multiplying the consumption frequency of each dietary item by the nutrient content of its respective specified portions. Multivariable analyses for the primary (disease-free survival [DFS]) and secondary (overall survival [OS]) endpoints were adjusted for sociodemographic, clinical, dietary, and lifestyle factors. Bonferroni corrections were applied for analyses of flavonoid subclasses and flavonoid-rich foods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over median follow-up of 5.9 years, flavonoid consumption either overall or by subclasses was not significantly associated with survival outcomes, with a hazard ratio (HR) (95% confidence interval [CI]) of 1.01 (0.75-1.37) for DFS among those in the highest relative to lowest consumption quintiles of total flavonoids. Exploratory analyses of flavonoid-rich foods intake did not demonstrate significant associations with DFS or OS after Bonferroni correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among resected stage III colon cancer patients who received standardized treatment and follow-up within a nationwide randomized clinical trial, consumption of flavonoids was not associated with survival outcomes.<\/jats:p>\n                    <jats:p>ClinicalTrials.gov identifier: NCT01150045<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jncics\/pkag112","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:27:03Z","timestamp":1792567623000},"source":"Crossref","is-referenced-by-count":0,"title":["Flavonoids and survival in stage III colon cancer: CALGB\/SWOG 80702 (alliance)"],"prefix":"10.1093","author":[{"given":"Seohyuk","family":"Lee","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center Department of Medicine, , Boston, MA","place":["USA"]},{"name":"Mayo Clinic Department of Medical Oncology, , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"Dana-Farber\/Partners CancerCare Department of Medical Oncology, , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Shi","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alliance Statistics and Data Management Center, , Rochester, MN,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Illinois CancerCare PC , Peoria, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Couture","sequence":"additional","affiliation":[{"name":"H\u00f4tel-Dieu de Qu\u00e9bec , Qu\u00e9bec, QC,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Kuebler","sequence":"additional","affiliation":[{"name":"Columbus NCI Community Oncology Research Program , Columbus, OH,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smitha","family":"Krishnamurthi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic , Cleveland, OH,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Tan","sequence":"additional","affiliation":[{"name":"Siteman Cancer Center, Washington University School of Medicine , Saint Louis, MO,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardaman","family":"Shergill","sequence":"additional","affiliation":[{"name":"Alliance for Clinical Trials in Oncology , Chicago, IL,","place":["USA"]},{"name":"The University of Chicago Medical Center , Chicago, IL,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen M","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center , Weill Cornell Medical Center, New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony F","family":"Shields","sequence":"additional","affiliation":[{"name":"Karmanos Cancer Institute, Wayne State University , Detroit, MI,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A","family":"Meyerhardt","sequence":"additional","affiliation":[{"name":"Dana-Farber\/Partners CancerCare Department of Medical Oncology, , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,21]]},"container-title":["JNCI Cancer Spectrum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jncics\/advance-article-pdf\/doi\/10.1093\/jncics\/pkag112\/72201461\/pkag112.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jncics\/advance-article-pdf\/doi\/10.1093\/jncics\/pkag112\/72201461\/pkag112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:27:04Z","timestamp":1792567624000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jncics\/advance-article\/doi\/10.1093\/jncics\/pkag112\/8956119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/jncics\/pkag112","relation":{},"ISSN":["2515-5091"],"issn-type":[{"value":"2515-5091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"article-number":"pkag112"}}