{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:16:14Z","timestamp":1790878574278,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":190,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis, Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["R01AR060209"],"award-info":[{"award-number":["R01AR060209"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA194118"],"award-info":[{"award-number":["R21CA194118"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001427"],"award-info":[{"award-number":["UL1TR001427"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001368","name":"V Foundation for Cancer Research","doi-asserted-by":"publisher","award":["V2015-021"],"award-info":[{"award-number":["V2015-021"]}],"id":[{"id":"10.13039\/100001368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32-HD-043730"],"award-info":[{"award-number":["T32-HD-043730"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical and Translational Science Award","award":["UL1-TR001430"],"award-info":[{"award-number":["UL1-TR001430"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cancer cachexia is a catabolic condition characterized by skeletal muscle wasting, consequent to tumor burden, which negatively impacts tolerance to cancer therapies and contributes to increased mortality. Partly because of the limited knowledge of the underlying mechanisms of cancer cachexia derived from human studies, however, the ability to therapeutically intervene remains elusive. The purpose of the current study was therefore to better define the phenotype of skeletal muscle obtained from patients with pancreatic ductal adenocarcinoma (PDAC), which has one of the highest rates of cachexia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Morphological analyses were performed on rectus abdominis muscle biopsies obtained from resectable PDAC patients undergoing tumor resection surgery (N\u2009=\u200920) and from weight-stable non-cancer control subjects undergoing benign abdominal surgery (N\u2009=\u200916). PDAC patients with a body weight loss of greater than 5% during the previous 6\u2009months were considered cachectic (N\u2009=\u200915). Statistical tests were two sided.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Skeletal muscle from cachectic PDAC patients had increased collagen content compared with non-cancer control subjects (1.43% vs 9.66%, P\u2009=\u2009.0004, Dunn test). Across all PDAC patients, collagen content positively correlated with body weight loss (P\u2009=\u2009.0016, r\u2009=\u20090.672), was increased in patients with lymph node metastasis (P\u2009=\u2009.007, Mann-Whitney U test), and was associated with survival on univariate (HR\u2009=\u20091.08, 95% confidence interval [CI] = 1.02 to 1.04, P\u2009=\u2009.008) and multivariable analyses (HR\u2009=\u20091.08, 95% CI = 1.00 to 1.17, P\u2009=\u2009.038). Cachectic PDAC patients also displayed increased lipid deposition (2.63% vs 5.72%, P\u2009=\u2009.042), infiltration of CD68+ macrophages (63.6 cells\/mm2 vs 233.8 cells\/mm2, P\u2009=\u2009.0238), calcium deposition (0.21% vs 2.51%, P\u2009=\u2009.030), and evidence of deficient cellular quality control mechanisms (Mann-Whitney U test). Transcriptional profiling of all patients supported these findings by identifying gene clusters related to wounding, inflammation, and cellular response to TGF-\u03b2 upregulated in cachectic PDAC patients compared with non-cancer control subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>To our knowledge, this work is the first to demonstrate increased collagen content in cachectic PDAC patients that is associated with poor survival.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jncics\/pky043","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T19:20:10Z","timestamp":1532632810000},"source":"Crossref","is-referenced-by-count":88,"title":["Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival"],"prefix":"10.1093","volume":"2","author":[{"given":"Sarah M","family":"Judge","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, University of Florida Health Science Center, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L","family":"Nosacka","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Florida Health Science Center, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Delitto","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles E","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G","family":"Trevino","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, University of Florida Health Science Center, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R","family":"Judge","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Florida Health Science Center, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"issue":"5","key":"2019070511330739200_pky043-B1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an 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