{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:42:41Z","timestamp":1790678561102,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Frequent detection of serous tubal intraepithelial carcinoma (STIC) among BRCA1\/2 mutation carriers undergoing risk-reducing surgery prompted the hypothesis that many adnexal high-grade serous carcinomas (HGSCs) arise from the fallopian tube, rather than the ovary, as supposed. The changing paradigm has important implications for HGSC prevention. Most data related to the frequency of STIC are derived from case series and estimates vary widely. Therefore, we analyzed population-based data from 10\u00a0523 surgeries including salpingectomy (Jan 2014\u2013Dec 2016) that were examined using the \u201cSectioning and Extensively Examining the Fimbria\u201d protocol, which optimizes STIC detection. Overall, STIC was detected in 40 (0.38%) specimens, including 32 diagnosed with concurrent gynecologic cancer. STIC was detected in 8 (&lt;0.01%) of 9392 cases with benign diagnoses. We conclude that the relative rarity of STIC diagnoses in routine pathology practice has critical implications for research aiming to elucidate the pathogenesis of HGSC and developing prevention strategies.<\/jats:p>","DOI":"10.1093\/jncics\/pky061","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T20:03:27Z","timestamp":1538683407000},"source":"Crossref","is-referenced-by-count":49,"title":["Population Frequency of Serous Tubal Intraepithelial Carcinoma (STIC) in Clinical Practice Using SEE-Fim Protocol"],"prefix":"10.1093","volume":"2","author":[{"given":"Goli","family":"Samimi","sequence":"first","affiliation":[{"name":"Division of Cancer Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britton","family":"Trabert","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M","family":"Geczik","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ire A","family":"Duggan","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Bethesda, MD; Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E","family":"Sherman","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Mayo Clinic, Jacksonville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"issue":"4","key":"2019070511530107200_pky061-B1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian 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