{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:25:50Z","timestamp":1787009150249,"version":"build-2736575974"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:00:00Z","timestamp":1570492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01 CA157823"],"award-info":[{"award-number":["1R01 CA157823"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We evaluated for the first time, to our knowledge, adverse health outcomes (AHOs) among US testicular cancer survivors (TCS) given chemotherapy (n\u2009=\u2009381) vs surgery-only patients (n\u2009=\u200998) managed at a single institution, accounting for non-treatment-related risk factors to delineate chemotherapy\u2019s impact. Chemotherapy consisted largely of bleomycin-etoposide-cisplatin (BEP) administered in three or four cycles (BEPx3, n\u2009=\u2009235; BEPx4, n\u2009=\u200982). Incidence of at least 3 AHOs was lowest in surgery-only TCS and increased with BEPx3, BEPx4, and other cisplatin-based regimens (12.2%, 40.8%, 52.5%, 54.8%; P\u2009&amp;lt;\u2009.0001). Multivariable modeling assessed associations of risk factors and treatment with hearing impairment, tinnitus, peripheral neuropathy, and Raynaud phenomenon. Risk for each AHO statistically increased with both increasing chemotherapy burden (P\u2009&amp;lt;\u2009.0001) and selected modifiable risk factors (P\u2009&amp;lt;\u2009.05): hypertension (odds ratio [OR]\u2009=\u20092.40) and noise exposure (OR\u2009\u2265\u20092.3) for hearing impairment; noise exposure for tinnitus (OR\u2009\u2265\u20091.69); peripheral vascular disease for neuropathy (OR\u2009=\u20098.72); and current smoking for Raynaud phenomenon (OR\u2009=\u20092.41). Clinicians should manage modifiable risk factors for AHOs among TCS.<\/jats:p>","DOI":"10.1093\/jncics\/pkz079","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T15:36:35Z","timestamp":1570030595000},"source":"Crossref","is-referenced-by-count":22,"title":["Adverse Health Outcomes Among US Testicular Cancer Survivors After Cisplatin-Based Chemotherapy vs Surgical Management"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6383-3777","authenticated-orcid":false,"given":"Vaibhav","family":"Agrawal","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Paul C","family":"Dinh","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"},{"name":"Department of Epidemiology and Biostatistics, Indiana University of Public Health, Bloomington, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunkit","family":"Fung","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"},{"name":"Division of Hematology and Oncology, Department of Medicine, University of Rochester School of Medicine and Dentistry, James P. Wilmot Cancer Institute, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick O","family":"Monahan","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra K","family":"Althouse","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Norton","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint","family":"Cary","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"},{"name":"Department of Urology, Indiana University School of Medicine, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Einhorn","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie D","family":"Fossa","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"},{"name":"Department of Oncology, Oslo University Hospital, Radium Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Adra","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, 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