{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:22:17Z","timestamp":1790400137621,"version":"4.1.0"},"reference-count":91,"publisher":"Oxford University Press (OUP)","issue":"58","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Plant-based, synthetic, and endogenous cannabinoids have been shown to control a diverse array of biological processes, including regulation of cell fate across cancers. Their promise as broad-based antitumor agents in preclinical models has led to the initiation of pilot clinical trials. Session 5 of the National Cancer Institute\u2019s Cannabis, Cannabinoids and Cancer Research Symposium provides an overview of this research topic. Overall, the presentations highlight cannabinoid signal transduction and specific molecular mechanisms underlying cannabinoid antitumor activity. They also demonstrate the broad-based antitumor activity of the plant-based, synthetic, and endogenous cannabinoid compounds. Importantly, evidence is presented demonstrating when cannabinoids may be contraindicated as a treatment for cancer, as in the case of human papilloma virus\u2013meditated oropharynx cancer or potentially other p38 MAPK pathway\u2013driven cancers. Finally, it is discussed that a key to advancing cannabinoids into the clinic is to conduct well-designed, large-scale clinical trials to determine whether cannabinoids are effective antitumor agents in cancer patients.<\/jats:p>","DOI":"10.1093\/jncimonographs\/lgab008","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T03:27:59Z","timestamp":1629343679000},"page":"99-106","source":"Crossref","is-referenced-by-count":24,"title":["Cannabinoid Cancer Biology and Prevention"],"prefix":"10.1093","volume":"2021","author":[{"given":"Sean D","family":"McAllister","sequence":"first","affiliation":[{"name":"California Pacific Medical Center Research Institute, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E","family":"Abood","sequence":"additional","affiliation":[{"name":"Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Califano","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2014Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA"},{"name":"Moores Cancer Center, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, CIBERNED, IUIN and IRYCIS, Complutense University, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"issue":"12","key":"2021120111525626700_lgab008-B1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0166-2236(98)01283-1","article-title":"Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action","volume":"21","author":"Di Marzo","year":"1998","journal-title":"Trends Neurosci"},{"issue":"5","key":"2021120111525626700_lgab008-B2","first-page":"605","article-title":"Determination and characterization of a cannabinoid receptor in rat brain","volume":"34","author":"Devane","year":"1988","journal-title":"Mol Pharmacol"},{"issue":"6284","key":"2021120111525626700_lgab008-B3","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/346561a0","article-title":"Structure of a cannabinoid receptor and functional expression of the cloned cDNA","volume":"346","author":"Matsuda","year":"1990","journal-title":"Nature"},{"issue":"5090","key":"2021120111525626700_lgab008-B4","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science"},{"issue":"1","key":"2021120111525626700_lgab008-B5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","article-title":"Identification of a 2-mono-glyceride, present in canine gut, that binds to cannabinoid receptors","volume":"50","author":"Mechoulam","year":"1995","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"2021120111525626700_lgab008-B6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/bbrc.1996.1757","article-title":"2-arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells","volume":"229","author":"Sugiura","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2021120111525626700_lgab008-B7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.pnpbp.2012.02.009","article-title":"Cannabinoid receptors: nomenclature and pharmacological principles","volume":"38","author":"Console-Bram","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"4","key":"2021120111525626700_lgab008-B8","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/pr.110.003004","article-title":"International Union of Basic and Clinical Pharmacology. 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