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Herein, the metabolic and circadian rhythm mechanisms underlying the proposed benefits of intermittent fasting for the cancer population are described. We summarize epidemiological, preclinical, and clinical studies in cancer published between January 2020 and August 2022 and propose avenues for future research. An outstanding concern regarding the use of intermittent fasting among cancer patients is that fasting often results in caloric restriction, which can put patients already prone to malnutrition, cachexia, or sarcopenia at risk. Although clinical trials do not yet provide sufficient data to support the general use of intermittent fasting in clinical practice, this summary may be useful for patients, caregivers, and clinicians who are exploring intermittent fasting as part of their cancer journey for clinical outcomes and symptom management.<\/jats:p>","DOI":"10.1093\/jncimonographs\/lgad008","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T23:31:46Z","timestamp":1676935906000},"page":"84-103","source":"Crossref","is-referenced-by-count":47,"title":["Intermittent fasting interventions to leverage metabolic and circadian mechanisms for cancer treatment and supportive care outcomes"],"prefix":"10.1093","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-4009","authenticated-orcid":false,"given":"Faiza","family":"Kalam","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University. Chicago , IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-9185","authenticated-orcid":false,"given":"Dara L","family":"James","sequence":"additional","affiliation":[{"name":"College of Nursing, University of South Alabama , Mobile, AL, USA"},{"name":"Edson College of Nursing and Health Innovation, Arizona State University , Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8077-4975","authenticated-orcid":false,"given":"Yun Rose","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and Cancer Genetics and Epigenetics, City of Hope , Duarte, CA, USA"},{"name":"Division of Quantitative Medicine & Systems Biology, Translational Genomics Research Institute , Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6914-848X","authenticated-orcid":false,"given":"Michael 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