{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:34:27Z","timestamp":1789598067850,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuropathol Exp Neurol"],"published-print":{"date-parts":[[2000,3]]},"DOI":"10.1093\/jnen\/59.3.188","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T23:35:50Z","timestamp":1452555350000},"page":"188-196","source":"Crossref","is-referenced-by-count":59,"title":["Novel Cerebral Lesions in the Eker Rat Model of Tuberous Sclerosis: Cortical Tuber and Anaplastic Ganglioglioma"],"prefix":"10.1093","volume":"59","author":[{"given":"Masashi","family":"Mizuguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachio","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yamanouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Mitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okio","family":"Hino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2016011115353903000_59.3.188.1","first-page":"339","article-title":"The pathology of tuberous sclerosis","volume":"17","author":"Bender","year":"1982","journal-title":"Pathol Annu"},{"key":"2016011115353903000_59.3.188.2","first-page":"1201","article-title":"Tuberous sclerosis-associated renal cell carcinoma","volume":"149","author":"Bjornsson","year":"1996","journal-title":"Clinical, pathological, and genetic features. Am J Pathol"},{"key":"2016011115353903000_59.3.188.3","unstructured":"Mizuguchi M Yamanouchi H Takashima S . Neurological aspects of tuberous sclerosis. In: Niimura M Otsuka F Okio H , eds. Phacomatosis in Japan. Epidemiology, clinical picture, and molecular biology. Tokyo: Japan Scientific Societic Press, 1999:61\u201371"},{"key":"2016011115353903000_59.3.188.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90416-8"},{"key":"2016011115353903000_59.3.188.5","doi-asserted-by":"publisher","DOI":"10.1038\/ng0992-37"},{"key":"2016011115353903000_59.3.188.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5327.805"},{"key":"2016011115353903000_59.3.188.7","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90618-Z"},{"key":"2016011115353903000_59.3.188.8","first-page":"4766","article-title":"Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles","volume":"58","author":"Plank","year":"1998","journal-title":"Cancer Res"},{"key":"2016011115353903000_59.3.188.9","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.6.1053"},{"key":"2016011115353903000_59.3.188.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1996.tb00866.x"},{"key":"2016011115353903000_59.3.188.11","first-page":"1071","article-title":"Tissue and cell-type specific expression of the tuberous sclerosis gene, TSC2, in human tissues","volume":"9","author":"Menchine","year":"1996","journal-title":"Mod Pathol"},{"key":"2016011115353903000_59.3.188.12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400621"},{"key":"2016011115353903000_59.3.188.13","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050746"},{"key":"2016011115353903000_59.3.188.14","first-page":"1639","article-title":"Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors","volume":"151","author":"Henske","year":"1997","journal-title":"Am J Pathol"},{"key":"2016011115353903000_59.3.188.15","first-page":"43","article-title":"Expression of the TSC2 product tuberin and its target Rap1 in normal human tissues","volume":"150","author":"Wienecke","year":"1997","journal-title":"Am J Pathol"},{"key":"2016011115353903000_59.3.188.16","first-page":"952","article-title":"HMB-45 and tuberin in hamartomas associated with tuberous sclerosis","volume":"10","author":"Kimura","year":"1997","journal-title":"Mod Pathol"},{"key":"2016011115353903000_59.3.188.17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1750-3639.1999.tb00209.x","article-title":"Colocalization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis","volume":"9","author":"Johnson","year":"1999","journal-title":"Brain Pathol"},{"key":"2016011115353903000_59.3.188.18","doi-asserted-by":"publisher","DOI":"10.1038\/ng0195-70"},{"key":"2016011115353903000_59.3.188.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.1.327"},{"key":"2016011115353903000_59.3.188.20","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/S0022-5347(17)37087-8","article-title":"Hereditary renal cell carcinoma in the Eker rat: A rodent familial cancer syndrome","volume":"148","author":"Everitt","year":"1992","journal-title":"J Urol"},{"key":"2016011115353903000_59.3.188.21","first-page":"1477","article-title":"Subependymal astrocytic hamartoma in the Eker rat model of tuberous sclerosis","volume":"151","author":"Yeung","year":"1997","journal-title":"Am J Pathol"},{"key":"2016011115353903000_59.3.188.22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb37743.x"},{"key":"2016011115353903000_59.3.188.23","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021963"},{"key":"2016011115353903000_59.3.188.24","first-page":"16409","article-title":"Identification of tuberin, the tuberous sclerosis-2 product","volume":"170","author":"Wienecke","year":"1995","journal-title":"Tuberin possesses specific Rap1GAP activity. J Biol Chem"},{"key":"2016011115353903000_59.3.188.25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.10.6097"},{"key":"2016011115353903000_59.3.188.26","first-page":"29301","article-title":"Role of the tuberous sclerosis gene-2 product in cell cycle control","volume":"272","author":"Soucek","year":"1997","journal-title":"Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase. J Biol Chem"},{"key":"2016011115353903000_59.3.188.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80657-1"},{"key":"2016011115353903000_59.3.188.28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.4.820"},{"key":"2016011115353903000_59.3.188.29","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.2.249"},{"key":"2016011115353903000_59.3.188.30","doi-asserted-by":"publisher","DOI":"10.1086\/301705"},{"key":"2016011115353903000_59.3.188.31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/jmg.36.4.285","article-title":"Mutational spectrum of the TSC1 gene in a cohort of 225 tuberous sclerosis complex patients: No evidence for genotype-phenotype correlation","volume":"36","author":"van Slegtenhorst","year":"1999","journal-title":"J Med Genet"},{"key":"2016011115353903000_59.3.188.32","doi-asserted-by":"publisher","DOI":"10.1086\/302381"},{"key":"2016011115353903000_59.3.188.33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.1998.6240277.x"},{"key":"2016011115353903000_59.3.188.34","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/3.10.1829"},{"key":"2016011115353903000_59.3.188.35","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/3.10.1833"},{"key":"2016011115353903000_59.3.188.36","doi-asserted-by":"publisher","DOI":"10.1038\/ng0294-193"},{"key":"2016011115353903000_59.3.188.37","first-page":"400","article-title":"Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions","volume":"59","author":"Henske","year":"1996","journal-title":"Am J Hum Genet"},{"key":"2016011115353903000_59.3.188.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(97)00036-2"},{"key":"2016011115353903000_59.3.188.39","doi-asserted-by":"publisher","DOI":"10.1148\/110.3.635"},{"key":"2016011115353903000_59.3.188.40","first-page":"649","article-title":"Glioblastoma multiforme with tuberous sclerosis","volume":"104","author":"Padmaltha","year":"1980","journal-title":"Report of a case. Arch Pathol Lab Med"},{"key":"2016011115353903000_59.3.188.41","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(94)90307-7"},{"key":"2016011115353903000_59.3.188.42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.14152"},{"key":"2016011115353903000_59.3.188.43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15629"}],"container-title":["Journal of Neuropathology & Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/59\/3\/188\/8132216\/59-3-188.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T12:59:47Z","timestamp":1692190787000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article-lookup\/doi\/10.1093\/jnen\/59.3.188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2000,3,1]]},"published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1093\/jnen\/59.3.188"],"URL":"https:\/\/doi.org\/10.1093\/jnen\/59.3.188","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}