{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:56:59Z","timestamp":1791417419806,"version":"4.3.3"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuropathol Exp Neurol"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1093\/jnen\/59.8.723","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T23:46:34Z","timestamp":1452555994000},"page":"723-732","source":"Crossref","is-referenced-by-count":80,"title":["Amyloid \u03b2 Protein (A\u03b2) Starts to Deposit As Plasma Membrane-Bound Form in Diffuse Plaques of Brains from Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch Type, Alzheimer Disease and Nondemented Aged Subjects"],"prefix":"10.1093","volume":"59","author":[{"given":"Haruyasu","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion L. C.","family":"Maat-Schieman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd G.","family":"van Duinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans A.","family":"Prins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Neeskens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco","family":"Natt\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymund A. C.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"2016030221162055000_59.8.723.1","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/S0021-9258(18)53661-9","article-title":"Structural alterations in the peptides backbone of \u03b2-amyloid core protein may account for its deposition and stability in Alzheimer's disease","volume":"268","author":"Roher","year":"1993","journal-title":"J Biol Chem"},{"key":"2016030221162055000_59.8.723.2","doi-asserted-by":"publisher","DOI":"10.1038\/325733a0"},{"key":"2016030221162055000_59.8.723.3","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90409-Z"},{"key":"2016030221162055000_59.8.723.4","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050452"},{"key":"2016030221162055000_59.8.723.5","doi-asserted-by":"publisher","DOI":"10.1038\/383710a0"},{"key":"2016030221162055000_59.8.723.6","doi-asserted-by":"publisher","DOI":"10.1038\/nm0198-097"},{"key":"2016030221162055000_59.8.723.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.2111584"},{"key":"2016030221162055000_59.8.723.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227745"},{"key":"2016030221162055000_59.8.723.9","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051143"},{"key":"2016030221162055000_59.8.723.10","first-page":"1257","article-title":"Predominant deposition of amyloid-\u03b242(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene","volume":"148","author":"Mann","year":"1996","journal-title":"Am J Pathol"},{"key":"2016030221162055000_59.8.723.11","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90458-8"},{"key":"2016030221162055000_59.8.723.12","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91725-6"},{"key":"2016030221162055000_59.8.723.13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/13506129509031882","article-title":"Immunohistochemical analysis of COOH-termini of amyloid beta protein (A\u03b2) using end-specific antisera for A\u03b240 and A\u03b242 in Alzheimer's disease and normal aging","volume":"2","author":"Yamaguchi","year":"1995","journal-title":"Amyloid: Int J Clin Invest"},{"key":"2016030221162055000_59.8.723.14","doi-asserted-by":"publisher","DOI":"10.1021\/bi00069a001"},{"key":"2016030221162055000_59.8.723.15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687584"},{"key":"2016030221162055000_59.8.723.16","first-page":"593","article-title":"Electron micrograph of diffuse plaques: Initial stage of senile plaque formation in the Alzheimer brain","volume":"135","author":"Yamaguchi","year":"1989","journal-title":"Am J Pathol"},{"key":"2016030221162055000_59.8.723.17","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050790"},{"key":"2016030221162055000_59.8.723.18","first-page":"98","article-title":"Reflection contrast microscopy","volume":"11","author":"Ploem","year":"1997","journal-title":"Leica Scientific and Technical Information"},{"key":"2016030221162055000_59.8.723.19","first-page":"47","article-title":"Reflection-contrast microscopy for high definition images with light microscopy: Practical tips using new Leica DMR equipment for RCM","volume":"CDR1","author":"Ploem","year":"1998","journal-title":"Leica Scientific and Technical Information"},{"key":"2016030221162055000_59.8.723.20","doi-asserted-by":"publisher","DOI":"10.1007\/BF00592572"},{"key":"2016030221162055000_59.8.723.21","unstructured":"Peters A Palay SL Webster HdeF . The fine structure of the nervous system. 3rd ed, Oxford, Oxford university Press, 1991:70\u2013100"},{"key":"2016030221162055000_59.8.723.22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689591"},{"key":"2016030221162055000_59.8.723.23","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90080-8"},{"key":"2016030221162055000_59.8.723.24","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-192301000-00001"},{"key":"2016030221162055000_59.8.723.25","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893605"},{"key":"2016030221162055000_59.8.723.26","doi-asserted-by":"publisher","DOI":"10.1007\/BF00310918"},{"key":"2016030221162055000_59.8.723.27","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199205000-00006"},{"key":"2016030221162055000_59.8.723.28","first-page":"1594","article-title":"Is the \u201cpreamyloid\u201d of diffuse plaques in Alzheimer's disease really nonfibrillar?","volume":"143","author":"Davies","year":"1993","journal-title":"Am J Pathol"},{"key":"2016030221162055000_59.8.723.29","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90636-8"},{"key":"2016030221162055000_59.8.723.30","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90416-9"},{"key":"2016030221162055000_59.8.723.31","first-page":"777","article-title":"Diffuse senile plaques: amorphous or fibrous?","volume":"146","author":"Bugiani","year":"1995","journal-title":"Am J Pathol"},{"key":"2016030221162055000_59.8.723.32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.1997.8498084.x"},{"key":"2016030221162055000_59.8.723.33","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051121"},{"key":"2016030221162055000_59.8.723.34","first-page":"249","article-title":"Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease","volume":"141","author":"Yamaguchi","year":"1992","journal-title":"An immunoelectron microscopic study. Am J Pathol"},{"key":"2016030221162055000_59.8.723.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80109-X"},{"key":"2016030221162055000_59.8.723.36","first-page":"138","article-title":"Ultrastructural studies of vascular lesion in experimental amyloidosis of mice","volume":"119","author":"Schultz","year":"1985","journal-title":"Am J Pathol"},{"key":"2016030221162055000_59.8.723.37","first-page":"335","article-title":"Familial amyloidosis: A histopathological study","volume":"34","author":"Tanimura","year":"1984","journal-title":"Acta Pathol Jpn"},{"key":"2016030221162055000_59.8.723.38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00266791","article-title":"New sensitive light microscopic detection of collidal gold on ultrathin sections by reflection contrast microscopy: combination of reflection contrast and electron microscopy in post-embedding immunogold histochemistry","volume":"94","author":"Cornelese-ten Velde","year":"1990","journal-title":"Histochemistry"},{"key":"2016030221162055000_59.8.723.39","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274094"},{"key":"2016030221162055000_59.8.723.40","doi-asserted-by":"publisher","DOI":"10.1038\/nm0997-1021"},{"key":"2016030221162055000_59.8.723.41","doi-asserted-by":"publisher","DOI":"10.1038\/nm0997-1016"},{"key":"2016030221162055000_59.8.723.42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.26.16085"},{"key":"2016030221162055000_59.8.723.43","doi-asserted-by":"publisher","DOI":"10.1021\/bi9816195"},{"key":"2016030221162055000_59.8.723.44","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64700-1"},{"key":"2016030221162055000_59.8.723.45","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04937-5"},{"key":"2016030221162055000_59.8.723.46","doi-asserted-by":"publisher","DOI":"10.1038\/nm1095-1062"},{"key":"2016030221162055000_59.8.723.47","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.37.22987"},{"key":"2016030221162055000_59.8.723.48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.16.7437"},{"key":"2016030221162055000_59.8.723.49","doi-asserted-by":"publisher","DOI":"10.1021\/bi981843u"},{"key":"2016030221162055000_59.8.723.50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14945"},{"key":"2016030221162055000_59.8.723.51","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0005-2736(98)00097-2","article-title":"Cholesterol-dependent generation of a unique amyloid \u03b2-protein from apically missorted amyloid precursor protein in MDCK cells","volume":"1373","author":"Mizuno","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"2016030221162055000_59.8.723.52","doi-asserted-by":"publisher","DOI":"10.1038\/nm0698-730"},{"key":"2016030221162055000_59.8.723.53","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389492"},{"key":"2016030221162055000_59.8.723.54","unstructured":"Yamaguchi H Sugihara S . A\u03b2 and its associated proteins with aging: Comparison between senile plaques and amyloid angiopathy. In: Iqbal K Winblad B Nishimura T Takeda M Wisniewski HM , eds. Alzheimer's disease: Biology, diagnosis and therapeutics. Chichester: John Wiley & Sons, 1997:305\u20139"}],"container-title":["Journal of Neuropathology & Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/59\/8\/723\/8133409\/59-8-723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T11:27:07Z","timestamp":1654082827000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article-lookup\/doi\/10.1093\/jnen\/59.8.723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":54,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2000,8,1]]},"published-print":{"date-parts":[[2000,8]]}},"alternative-id":["10.1093\/jnen\/59.8.723"],"URL":"https:\/\/doi.org\/10.1093\/jnen\/59.8.723","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}