{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:03:55Z","timestamp":1791896635357,"version":"4.3.4"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuropathol Exp Neurol"],"published-print":{"date-parts":[[2003,9]]},"DOI":"10.1093\/jnen\/62.9.885","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:51:18Z","timestamp":1452559878000},"page":"885-898","source":"Crossref","is-referenced-by-count":233,"title":["Cerebral Amyloid Angiopathies: A Pathologic, Biochemical, and Genetic View"],"prefix":"10.1093","volume":"62","author":[{"given":"Tamas","family":"Revesz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Ghiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammaryn","family":"Lashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Plant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agueda","family":"Rostagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blas","family":"Frangione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Holton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,9,1]]},"reference":[{"key":"2016011116510759000_62.9.885.1","first-page":"36","article-title":"Familial cerebral amyloid angiopathy related to stroke and dementia","volume":"8Suppl 1","author":"Frangione","year":"2001","journal-title":"Amyloid"},{"key":"2016011116510759000_62.9.885.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00149-7"},{"key":"2016011116510759000_62.9.885.3","first-page":"311","article-title":"Cerebral amyloid angiopathy","volume":"18","author":"Vinters","year":"1987","journal-title":"A critical review. Stroke"},{"key":"2016011116510759000_62.9.885.4","doi-asserted-by":"crossref","unstructured":"Plant GT Ghiso J Holton JL Frangione B Revesz T . Familial and sporadic cerebral amyloid angiopathies associated with dementia and the BRI dementias. In: Esiri MM Lee V-MY Trojanowski JQ , eds. The neuropathology of dementia. Cambridge: Cambridge University Press, in press","DOI":"10.1017\/CBO9780511526886.015"},{"key":"2016011116510759000_62.9.885.5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1750-3639.2002.tb00449.x","article-title":"Sporadic and familial cerebral amyloid angiopathies","volume":"12","author":"Revesz","year":"2002","journal-title":"Brain Pathol"},{"key":"2016011116510759000_62.9.885.6","doi-asserted-by":"crossref","unstructured":"Vinters HV Vonsattel JP . Neuropathologic features and grading of Alzheimer-related and sporadic CAA. In: Verbeek MM de Waal RMW Vinters HV , eds. Cerebral amyloid angiopathy in Alzheimer's disease and related disorders. Dordrecht: Kluwer Academic Publishers, 2000;137\u201355","DOI":"10.1007\/978-94-017-1007-7_8"},{"key":"2016011116510759000_62.9.885.7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300503"},{"key":"2016011116510759000_62.9.885.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63993-4"},{"key":"2016011116510759000_62.9.885.9","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.3.254"},{"key":"2016011116510759000_62.9.885.10","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000014774.88027.22"},{"key":"2016011116510759000_62.9.885.11","doi-asserted-by":"crossref","unstructured":"Greenberg SM . Clinical aspects and diagnostic criteria of sporadic CAA-related hemorrhage. In: Verbeek MM de Waal RMW Vinters HV , eds. Cerebral amyloid angiopathy in Alzheimer's disease and related disorders. Dordrecht: Kluwer Academic Publishers, 2000;3\u201319","DOI":"10.1007\/978-94-017-1007-7_1"},{"key":"2016011116510759000_62.9.885.12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1629"},{"key":"2016011116510759000_62.9.885.13","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1523\/JNEUROSCI.21-05-01619.2001","article-title":"Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy","volume":"21","author":"Winkler","year":"2001","journal-title":"J Neurosci"},{"key":"2016011116510759000_62.9.885.14","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/jnen\/59.9.768","article-title":"Cerebral beta amyloid angiopathy is a risk factor for cerebral ischemic infarction","volume":"59","author":"Cadavid","year":"2000","journal-title":"A case control study in human brain biopsies. J Neuropathol Exp Neurol"},{"key":"2016011116510759000_62.9.885.15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10040"},{"key":"2016011116510759000_62.9.885.16","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1009"},{"key":"2016011116510759000_62.9.885.17","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/jnen\/60.3.274","article-title":"Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy","volume":"60","author":"Kimchi","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"2016011116510759000_62.9.885.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04799.x"},{"key":"2016011116510759000_62.9.885.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04797.x"},{"key":"2016011116510759000_62.9.885.20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.6.1592"},{"key":"2016011116510759000_62.9.885.21","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380219"},{"key":"2016011116510759000_62.9.885.22","first-page":"2083","article-title":"Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease","volume":"148","author":"Premkumar","year":"1996","journal-title":"Am J Pathol"},{"key":"2016011116510759000_62.9.885.23","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199804000-00008"},{"key":"2016011116510759000_62.9.885.24","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410607"},{"key":"2016011116510759000_62.9.885.25","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: Genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol Rev"},{"key":"2016011116510759000_62.9.885.26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2002.tb00187.x"},{"key":"2016011116510759000_62.9.885.27","first-page":"1257","article-title":"Predominant deposition of amyloid-beta(42(43)) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene","volume":"148","author":"Mann","year":"1996","journal-title":"Am J Pathol"},{"key":"2016011116510759000_62.9.885.28","doi-asserted-by":"publisher","DOI":"10.1126\/science.2111584"},{"key":"2016011116510759000_62.9.885.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1996.tb00794.x"},{"key":"2016011116510759000_62.9.885.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64207-1"},{"key":"2016011116510759000_62.9.885.31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.160115697"},{"key":"2016011116510759000_62.9.885.32","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64688-3"},{"key":"2016011116510759000_62.9.885.33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007183200"},{"key":"2016011116510759000_62.9.885.34","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-002-0536-6"},{"key":"2016011116510759000_62.9.885.35","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430124"},{"key":"2016011116510759000_62.9.885.36","first-page":"132","article-title":"Apolipoprotein E and amyloidogenesis","volume":"199","author":"Frangione","year":"1996","journal-title":"Ciba Found Symp"},{"key":"2016011116510759000_62.9.885.37","first-page":"32185","article-title":"The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type","volume":"271","author":"Castano","year":"1996","journal-title":"Implications for the role of amyloid-beta 1\u201342 in Alzheimer's disease. J Biol Chem"},{"key":"2016011116510759000_62.9.885.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64644-5"},{"key":"2016011116510759000_62.9.885.39","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80406-7"},{"key":"2016011116510759000_62.9.885.40","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199801000-00009"},{"key":"2016011116510759000_62.9.885.41","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)91274-V"},{"key":"2016011116510759000_62.9.885.42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104135200"},{"key":"2016011116510759000_62.9.885.43","doi-asserted-by":"crossref","first-page":"27110","DOI":"10.1016\/S0021-9258(19)61486-9","article-title":"Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells","volume":"275","author":"Miravalle","year":"2000","journal-title":"J Biol Chem"},{"key":"2016011116510759000_62.9.885.44","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050944"},{"key":"2016011116510759000_62.9.885.45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.9.2974"},{"key":"2016011116510759000_62.9.885.46","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.5.1771"},{"key":"2016011116510759000_62.9.885.47","doi-asserted-by":"publisher","DOI":"10.3109\/13506120108993809"},{"key":"2016011116510759000_62.9.885.48","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00256.x"},{"key":"2016011116510759000_62.9.885.49","doi-asserted-by":"publisher","DOI":"10.1097\/60-1-94"},{"key":"2016011116510759000_62.9.885.50","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.6.763"},{"key":"2016011116510759000_62.9.885.51","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)00274-R"},{"key":"2016011116510759000_62.9.885.52","first-page":"351","article-title":"Leptomeningeal amyloid and variant transthyretins","volume":"148","author":"Benson","year":"1996","journal-title":"Am J Pathol"},{"key":"2016011116510759000_62.9.885.53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.9989"},{"key":"2016011116510759000_62.9.885.54","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.6.1562"},{"key":"2016011116510759000_62.9.885.55","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410305"},{"key":"2016011116510759000_62.9.885.56","first-page":"361","article-title":"Meningocerebrovascular amyloidosis associated with a novel transthyretin mis-sense mutation at codon 18 (TTRD 18G)","volume":"148","author":"Vidal","year":"1996","journal-title":"Am J Pathol"},{"key":"2016011116510759000_62.9.885.57","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/13506129809007291","article-title":"Gelsolin-related familial amyloidosis, Finnish type (FAF), and its variants found worldwide","volume":"5","author":"Kiuru","year":"1998","journal-title":"Amyloid: Int J Exp Clin Invest"},{"key":"2016011116510759000_62.9.885.58","first-page":"1223","article-title":"Amyloid in familial amyloidosis, Finnish type, is antigenically and structurally related to gelsolin","volume":"136","author":"Haltia","year":"1990","journal-title":"Am J Pathol"},{"key":"2016011116510759000_62.9.885.59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.6.1865"},{"key":"2016011116510759000_62.9.885.60","doi-asserted-by":"publisher","DOI":"10.1042\/bj2720827"},{"key":"2016011116510759000_62.9.885.61","first-page":"558","article-title":"Amyloid fibril formation in gelsolin-derived amyloidosis","volume":"70","author":"Maury","year":"1994","journal-title":"Definition of the amyloidogenic region and evidence of accelerated amyloid formation of mutant Asn-187 and Tyr-187 gelsolin peptides. Lab Invest"},{"key":"2016011116510759000_62.9.885.62","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199903)45:3<305::AID-ANA5>3.0.CO;2-E"},{"key":"2016011116510759000_62.9.885.63","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105173442006"},{"key":"2016011116510759000_62.9.885.64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.2.744"},{"key":"2016011116510759000_62.9.885.65","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.5.975"},{"key":"2016011116510759000_62.9.885.66","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.3.721"},{"key":"2016011116510759000_62.9.885.67","doi-asserted-by":"publisher","DOI":"10.1038\/21637"},{"key":"2016011116510759000_62.9.885.68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.080076097"},{"key":"2016011116510759000_62.9.885.69","doi-asserted-by":"publisher","DOI":"10.1038\/14783"},{"key":"2016011116510759000_62.9.885.70","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105956200"},{"key":"2016011116510759000_62.9.885.71","first-page":"49782","article-title":"Complement activation in chromosome 13 dementias","volume":"277","author":"Rostagno","year":"2002","journal-title":"Similarities with Alzheimer's disease. J Biol Chem"},{"key":"2016011116510759000_62.9.885.72","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00150-3"},{"key":"2016011116510759000_62.9.885.73","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00400-6"},{"key":"2016011116510759000_62.9.885.74","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.37.22908"},{"key":"2016011116510759000_62.9.885.75","first-page":"249","article-title":"Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease","volume":"141","author":"Yamaguchi","year":"1992","journal-title":"An immunoelectron microscopic study. Am J Pathol"},{"key":"2016011116510759000_62.9.885.76","first-page":"219","article-title":"High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice","volume":"149","author":"Fukuchi","year":"1996","journal-title":"Am J Pathol"},{"key":"2016011116510759000_62.9.885.77","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199411000-00011"},{"key":"2016011116510759000_62.9.885.78","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00180-Z"},{"key":"2016011116510759000_62.9.885.79","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1749-6632.2000.tb06381.x","article-title":"Mechanisms of cerebrovascular amyloid deposition","volume":"903","author":"Burgermeister","year":"2000","journal-title":"Lessons from mouse models. Ann NY Acad Sci"},{"key":"2016011116510759000_62.9.885.80","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65616-7"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T11:35:13Z","timestamp":1654083313000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article-lookup\/doi\/10.1093\/jnen\/62.9.885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":80,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2003,9,1]]},"published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1093\/jnen\/62.9.885"],"URL":"https:\/\/doi.org\/10.1093\/jnen\/62.9.885","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}