{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:46:35Z","timestamp":1773243995823,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuropathol Exp Neurol"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1093\/jnen\/63.6.610","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T01:07:41Z","timestamp":1452560861000},"page":"610-617","source":"Crossref","is-referenced-by-count":16,"title":["Apoptosis of Hippocampal Neurons in Organotypic Slice Culture Models: Direct Effect of Bacteria Revisited"],"prefix":"10.1093","volume":"63","author":[{"given":"Christian","family":"Gianinazzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Grandgirard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Imboden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Joss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin G.","family":"T\u00e4uber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Leib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,6,1]]},"reference":[{"key":"2016030222560239000_63.6.610.1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0092-8674(00)80483-3","article-title":"Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin","volume":"7","author":"Chen","year":"1997","journal-title":"Cell"},{"key":"2016030222560239000_63.6.610.2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1523\/JNEUROSCI.15-02-01001.1995","article-title":"Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis","volume":"2","author":"Nitatori","year":"1995","journal-title":"J Neurosci"},{"key":"2016030222560239000_63.6.610.3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00401-003-0672-7","article-title":"Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis","volume":"5","author":"Gianinazzi","year":"2003","journal-title":"Acta Neuropathol (Berl)"},{"key":"2016030222560239000_63.6.610.4","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.7999"},{"key":"2016030222560239000_63.6.610.5","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1074\/jbc.273.16.9357","article-title":"Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis","volume":"16","author":"Janicke","year":"1998","journal-title":"J Biol Chem"},{"key":"2016030222560239000_63.6.610.6","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1750-3639.2001.tb00410.x","article-title":"Expression of death-related proteins in dentate granule cells in human bacterial meningitis","volume":"4","author":"Gerber","year":"2001","journal-title":"Brain Pathol"},{"key":"2016030222560239000_63.6.610.7","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/6514","article-title":"Neuroprotection by a caspase inhibitor in acute bacterial meningitis","volume":"3","author":"Braun","year":"1999","journal-title":"Nat Med"},{"key":"2016030222560239000_63.6.610.8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/00005072-199606000-00006","article-title":"Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis","volume":"6","author":"Zysk","year":"1996","journal-title":"J Neuropathol Exp Neurol"},{"key":"2016030222560239000_63.6.610.9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1086\/317921","article-title":"The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis","volume":"2","author":"Loeffler","year":"2001","journal-title":"J Infect Dis"},{"key":"2016030222560239000_63.6.610.10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI12035","article-title":"Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis","volume":"1","author":"Braun","year":"2002","journal-title":"J Clin Invest"},{"key":"2016030222560239000_63.6.610.11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/nbdi.2002.0561","article-title":"Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase","volume":"3","author":"Stringaris","year":"2002","journal-title":"Neurobiol Dis"},{"key":"2016030222560239000_63.6.610.12","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/brain\/124.9.1734","article-title":"Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis","volume":"Pt 9","author":"Leib","year":"2001","journal-title":"Brain"},{"key":"2016030222560239000_63.6.610.13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-0270(91)90128-M","article-title":"A simple method for organotypic cultures of nervous tissue","volume":"2","author":"Stoppini","year":"1991","journal-title":"J Neurosci Methods"},{"key":"2016030222560239000_63.6.610.14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-0270(94)00147-9","article-title":"Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen\/glucose deprivation","volume":"2","author":"Strasser","year":"1995","journal-title":"J Neurosci Methods"},{"key":"2016030222560239000_63.6.610.15","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0022-3476(78)81213-X","article-title":"Ventricular involvement in experimental Hemophilus influenzae meningitis","volume":"6","author":"Daum","year":"1978","journal-title":"J Pediatr"},{"key":"2016030222560239000_63.6.610.16","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/infdis\/160.5.818","article-title":"Modulation of inflammation and cachectin activity in relation to treatment of experimental Hemophilus influenzae type b meningitis","volume":"5","author":"Mustafa","year":"1989","journal-title":"J Infect Dis"},{"key":"2016030222560239000_63.6.610.17","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1128\/AAC.47.8.2649-2654.2003","article-title":"Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone","volume":"8","author":"Spreer","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"2016030222560239000_63.6.610.18","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/infdis\/166.3.546","article-title":"Lactate and glucose concentrations in brain interstitial fluid, cerebrospinal fluid, and serum during experimental pneumococcal meningitis","volume":"3","author":"Guerra-Romero","year":"1992","journal-title":"J Infect Dis"},{"key":"2016030222560239000_63.6.610.19","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1203\/00006450-199611000-00016","article-title":"Near-infrared spectroscopy in experimental pneumococcal meningitis in the rabbit: Cerebral hemodynamics and metabolism","volume":"5","author":"Tureen","year":"1996","journal-title":"Pediatr Res"},{"key":"2016030222560239000_63.6.610.20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02736849","article-title":"Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9","volume":"1","author":"Cagnoli","year":"1996","journal-title":"J Mol Neurosci"},{"key":"2016030222560239000_63.6.610.21","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/excr.1997.3558","article-title":"Glutamate-treated rat cortical neuronal cultures die in a way different from the classical apoptosis induced by staurosporine","volume":"2","author":"MacManus","year":"1997","journal-title":"Exp Cell Res"},{"key":"2016030222560239000_63.6.610.22","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1523\/JNEUROSCI.18-20-08186.1998","article-title":"Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector","volume":"20","author":"Krohn","year":"1998","journal-title":"J Neurosci"},{"key":"2016030222560239000_63.6.610.23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0092-8674(00)80748-5","article-title":"Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation","volume":"3","author":"Gervais","year":"1999","journal-title":"Cell"},{"key":"2016030222560239000_63.6.610.24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0165-5728(00)00402-1","article-title":"Organotypic hippocampal culturesA model of brain tissue damage in Streptococcus pneumoniae meningitis","volume":"1","author":"Schmidt","year":"2001","journal-title":"J Neuroimmunol"},{"key":"2016030222560239000_63.6.610.25","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1750-3639.2001.tb00399.x","article-title":"Transcriptional regulation of caspases in experimental pneumococcal meningitis","volume":"3","author":"von Mering","year":"2001","journal-title":"Brain Pathol"},{"key":"2016030222560239000_63.6.610.26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/1531-8249(200003)47:3<329::AID-ANA8>3.0.CO;2-R","article-title":"Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis","volume":"3","author":"Pfister","year":"2000","journal-title":"Ann Neurol"},{"key":"2016030222560239000_63.6.610.27","doi-asserted-by":"crossref","unstructured":"Imboden H Felix D . Immunocytochemistry in brain tissue. In: Methods in neuroscience. Academic Press, Inc., 1995;24:236\u201360","DOI":"10.1016\/S1043-9471(06)80153-9"},{"key":"2016030222560239000_63.6.610.28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0006-8993(02)04080-5","article-title":"Colchicine induces apoptosis in organotypic hippocampal slice cultures","volume":"2","author":"Kristensen","year":"2003","journal-title":"Brain Res"},{"key":"2016030222560239000_63.6.610.29","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1182\/blood.V96.3.1030","article-title":"Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: Reversibility at low apoptotic insult","volume":"3","author":"Dumont","year":"2000","journal-title":"Blood"},{"key":"2016030222560239000_63.6.610.30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0306-4522(93)90335-D","article-title":"Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat","volume":"2","author":"Cameron","year":"1993","journal-title":"Neuroscience"},{"key":"2016030222560239000_63.6.610.31","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"11","author":"Eriksson","year":"1998","journal-title":"Nat Med"},{"key":"2016030222560239000_63.6.610.32","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0014-4827(91)90166-R","article-title":"Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases","volume":"1","author":"Abe","year":"1991","journal-title":"Exp Cell Res"},{"key":"2016030222560239000_63.6.610.33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1023\/A:1012564620853","article-title":"Cytotoxicity induced by manipulation of signal transduction pathways is associated with down-regulation of Bcl-2 but not Mcl-1 in MCF-7 human breast cancer","volume":"1","author":"Hu","year":"2001","journal-title":"Breast Cancer Res Treat"},{"key":"2016030222560239000_63.6.610.34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF01947561","article-title":"Slice cultures of cerebellar, hippocampal and hypothalamic tissue","volume":"3","author":"G\u00e4hwiler","year":"1984","journal-title":"Experientia"},{"key":"2016030222560239000_63.6.610.35","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1086\/324013","article-title":"Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus","volume":"10","author":"Braun","year":"2001","journal-title":"J Infect Dis"},{"key":"2016030222560239000_63.6.610.36","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1128\/IAI.64.8.3148-3153.1996","article-title":"Neurotoxicity of glia activated by gram-positive bacterial products depends on nitric oxide production","volume":"8","author":"Kim","year":"1996","journal-title":"Infect Immun"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T19:12:26Z","timestamp":1718305946000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article-lookup\/doi\/10.1093\/jnen\/63.6.610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2004,6,1]]},"published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1093\/jnen\/63.6.610"],"URL":"https:\/\/doi.org\/10.1093\/jnen\/63.6.610","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}