{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:45:56Z","timestamp":1791405956176,"version":"4.3.3"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuropathol Exp Neurol"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1093\/jnen\/64.5.378","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T01:22:45Z","timestamp":1452561765000},"page":"378-385","source":"Crossref","is-referenced-by-count":71,"title":["Decreased Neprilysin Immunoreactivity in Alzheimer Disease, but Not in Pathological Aging"],"prefix":"10.1093","volume":"64","author":[{"given":"Deng-Shun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy J.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Buschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Kuslansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Verghese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Younkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Eckman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,5,1]]},"reference":[{"key":"2016030222512282000_64.5.378.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072994"},{"key":"2016030222512282000_64.5.378.2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(93)90096-T"},{"key":"2016030222512282000_64.5.378.3","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00028-0"},{"key":"2016030222512282000_64.5.378.4","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(92)90027-U"},{"key":"2016030222512282000_64.5.378.5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/exnr.1999.7085","article-title":"The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging","volume":"815","author":"Wang","year":"1999","journal-title":"Exp Neurol"},{"key":"2016030222512282000_64.5.378.6","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(95)00013-5"},{"key":"2016030222512282000_64.5.378.7","unstructured":"Dickson DW Ivanushkin A Heitner J Yen S-H Davies P . Apolipoprotein-E immunoreactivity is increased in deposits of Alzheimer's disease, but not pathologic aging or diffuse Lewy body disease. In: Iqbal H Mortimer JA Winblad B Wisniewski HM , eds. Research Advances in Alzheimer's Disease and Related Disorders. New York: John Wiley & Sons, 1995:371\u201383"},{"key":"2016030222512282000_64.5.378.8","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00116-9"},{"key":"2016030222512282000_64.5.378.9","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199704000-00001"},{"key":"2016030222512282000_64.5.378.10","doi-asserted-by":"crossref","first-page":"10987","DOI":"10.1016\/S0021-9258(19)78080-6","article-title":"Chemical characterization of Abeta 17-42 peptide: A component of diffuse amyloid deposits of Alzheimer disease","volume":"269","author":"Gowing","year":"1994","journal-title":"J Biol Chem"},{"key":"2016030222512282000_64.5.378.11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.52.33623"},{"key":"2016030222512282000_64.5.378.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00253-1"},{"key":"2016030222512282000_64.5.378.13","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.9.1381"},{"key":"2016030222512282000_64.5.378.14","doi-asserted-by":"publisher","DOI":"10.1038\/nm0103-3"},{"key":"2016030222512282000_64.5.378.15","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1523\/JNEUROSCI.20-11-03937.2000","article-title":"The plasmin system is induced by and degrades amyloid-beta aggregates","volume":"20","author":"Tucker","year":"2000","journal-title":"J Neurosci"},{"key":"2016030222512282000_64.5.378.16","doi-asserted-by":"publisher","DOI":"10.1021\/bi011193l"},{"key":"2016030222512282000_64.5.378.17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1031520100"},{"key":"2016030222512282000_64.5.378.18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007579200"},{"key":"2016030222512282000_64.5.378.19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200642200"},{"key":"2016030222512282000_64.5.378.20","doi-asserted-by":"publisher","DOI":"10.1038\/72237"},{"key":"2016030222512282000_64.5.378.21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1096\/fasebj.11.5.9141502","article-title":"Mammalian membrane metallopeptidases: NEP, ECE, KELL and PEX","volume":"11","author":"Turner","year":"1997","journal-title":"FASEB J"},{"key":"2016030222512282000_64.5.378.22","doi-asserted-by":"publisher","DOI":"10.1002\/1521-1878(200103)23:3<261::AID-BIES1036>3.0.CO;2-K"},{"key":"2016030222512282000_64.5.378.23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00855.x"},{"key":"2016030222512282000_64.5.378.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(02)00015-9"},{"key":"2016030222512282000_64.5.378.25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64041826.x"},{"key":"2016030222512282000_64.5.378.26","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10390"},{"key":"2016030222512282000_64.5.378.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00030-2"},{"key":"2016030222512282000_64.5.378.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03008-6"},{"key":"2016030222512282000_64.5.378.29","doi-asserted-by":"crossref","unstructured":"Wang DS Cochran E Bennett DM Eckman EC Dickson DW . Amyloid, PHF-tau, ubiquitin and synaptic markers in the progression of Alzheimer's disease: Immunochemical analysis of frontal cortex from prospectively studied elderly humans. In: Iqbal K Sisodia SS Winblad B , eds. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics. New York: John Wiley & Sons, Ltd, 2001:165\u201380","DOI":"10.1002\/0470846453.ch16"},{"key":"2016030222512282000_64.5.378.30","unstructured":"Image J . Bethesda, MD: Research Services Branch, National Institute of Mental Health. November 17, 2004. Available at: http:\/\/rsb.info.nih.gov\/ij\/"},{"key":"2016030222512282000_64.5.378.31","doi-asserted-by":"publisher","DOI":"10.1006\/abio.2000.4772"},{"key":"2016030222512282000_64.5.378.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.01.044"},{"key":"2016030222512282000_64.5.378.33","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200007000-00003"},{"key":"2016030222512282000_64.5.378.34","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.8.1233"},{"key":"2016030222512282000_64.5.378.35","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a022839"},{"key":"2016030222512282000_64.5.378.36","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/S0021-9258(18)53661-9","article-title":"Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease","volume":"268","author":"Roher","year":"1993","journal-title":"J Biol Chem"},{"key":"2016030222512282000_64.5.378.37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7013"},{"key":"2016030222512282000_64.5.378.38","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617700000576"},{"key":"2016030222512282000_64.5.378.39","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.3.370"},{"key":"2016030222512282000_64.5.378.40","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jnen\/62.11.1087","article-title":"Neuropathology of cognitively normal elderly","volume":"62","author":"Knopman","year":"2003","journal-title":"J Neuropathol Exp Neurol"},{"key":"2016030222512282000_64.5.378.41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6448"},{"key":"2016030222512282000_64.5.378.42","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079469"},{"key":"2016030222512282000_64.5.378.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.09.003"},{"key":"2016030222512282000_64.5.378.44","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2303"},{"key":"2016030222512282000_64.5.378.45","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2302"},{"key":"2016030222512282000_64.5.378.46","unstructured":"Eckman EA Eckman CB . A\u03b2 degradation by endothelin-converting enzymes. In: Saido TC , ed. A\u03b2 Metabolism and Alzheimer's Disease. Georgetown, TX: Landes Bioscience, 2003:81\u201394"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T11:40:09Z","timestamp":1654083609000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article-lookup\/doi\/10.1093\/jnen\/64.5.378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2005,5,1]]},"published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1093\/jnen\/64.5.378"],"URL":"https:\/\/doi.org\/10.1093\/jnen\/64.5.378","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}