{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:36Z","timestamp":1792785996202,"version":"4.5.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T00:00:00Z","timestamp":1582502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Basic Science Research Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1A5A2008833"],"award-info":[{"award-number":["2015R1A5A2008833"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Obesity causes brain injuries with inflammatory and structural changes, leading to neurodegeneration. Although increased circulating lipocalin 2 (LCN2) level has been implicated in neurodegenerative diseases, the precise mechanism of neurodegeneration in obesity is not clear. Here, we investigated whether LCN2-mediated signaling promotes neurodegeneration in the hippocampus of leptin-deficient ob\/ob mice, which are characterized by obesity, insulin resistance, systemic inflammation, and neuroinflammation. In particular, there was significant upregulation of both LCN2 and matrix metalloproteinase 9 levels from serum and hippocampus in ob\/ob mice. Using RNA-seq analysis, we found that neurodegeneration- sortilin-related receptor 1 (Sorl1) and brain-derived neurotrophic factor (Bdnf) genes were significantly reduced in the hippocampus of ob\/ob mice. We additionally found that the endosome-related WD repeat and FYVE-domain-containing 1 (Wdfy1) gene were upregulated in ob\/ob mice. In particular, iron overload-related mitochondrial ferritin and nuclear factor erythroid 2-related factor 2 (Nrf2)\/heme oxygenase-1 (HO-1) proteins were increased in the hippocampus of ob\/ob. Thus, these findings indicate that iron-binding protein LCN2-mediated oxidative stress promotes neurodegeneration in ob\/ob mice.<\/jats:p>","DOI":"10.1093\/jnen\/nlaa017","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T04:06:21Z","timestamp":1587009981000},"page":"530-541","source":"Crossref","is-referenced-by-count":31,"title":["Hippocampal Lipocalin 2 Is Associated With Neuroinflammation and Iron-Related Oxidative Stress in ob\/ob Mice"],"prefix":"10.1093","volume":"79","author":[{"given":"Zhen","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Joo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ae","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Ah","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Youl","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong Seok","family":"An","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Bee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woori","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"},{"name":"C&K Genomics, Inc. , Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu Seob","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Convergence Medical Science , College of Medicine, Institute of Health Sciences, Bio Anti-aging Medical Research Center, Gyeongsang National University, Jinju-si, Gyeongnam, Republic of Korea (ZJ, KEK, HJS, EAJ, K-AP, JYL, HSA, EBC, JHJ, WK, GSR)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,24]]},"reference":[{"key":"2024032523321250300_nlaa017-B1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","article-title":"Obesity","volume":"366","author":"Haslam","year":"2005","journal-title":"Lancet"},{"key":"2024032523321250300_nlaa017-B2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bbadis.2008.10.004","article-title":"Obesity and vulnerability of the CNS","volume":"1792","author":"Bruce-Keller","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"2024032523321250300_nlaa017-B3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/dom.12124","article-title":"Diabetes and cancer: Two diseases with obesity as a common risk 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