{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:24:44Z","timestamp":1790267084815,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671235"],"award-info":[{"award-number":["81671235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"People\u2019s Benefit Project of Science and Technology in Qingdao","award":["16-6-2-1-nsh"],"award-info":[{"award-number":["16-6-2-1-nsh"]}]},{"name":"Taishan Scholars Program of Shandong Province"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Different mechanisms have been proposed to explain the pathological basis of perifascicular atrophy (PFA), a pathognomonic histologic feature of dermatomyositis (DM); however, the detailed mechanisms remain to be elucidated. There is mitochondrial dysfunction in PFA and expression of mitochondrial apoptosis molecules has been reported in DM. Overexpression of gasdermin E (GSDME) can turn mitochondrial apoptosis to mitochondrial pyroptosis, a newly characterized form of programmed cell death. We determined the expression of proteins involved in the caspase-3- and GSDME-dependent mitochondrial pyroptotic pathway, including BAX, BAK, cytochrome C, caspase-9, caspase-3, GSDME, and IL-1\u03b1, in biopsied muscles from DM and control patients. Immunohistochemical analysis showed that those markers were expressed in most fibers in PFA in DM. GSDME-positive and IL-1\u03b1-positive staining was mainly localized around punched-out vacuoles or sarcolemma. These markers were significantly upregulated at the protein and mRNA levels in DM versus controls. Our results suggest that caspase-3- and GSDME-dependent mitochondrial pyroptosis are involved in the pathogenetic mechanisms of PFA in DM and that targeting GSDME-dependent mitochondrial pyroptosis may be an effective therapeutic approach for this condition.<\/jats:p>","DOI":"10.1093\/jnen\/nlaa023","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T08:06:16Z","timestamp":1587024376000},"page":"551-561","source":"Crossref","is-referenced-by-count":15,"title":["Gasdermine E-Dependent Mitochondrial Pyroptotic Pathway in Dermatomyositis: A Possible Mechanism of Perifascicular Atrophy"],"prefix":"10.1093","volume":"79","author":[{"given":"Meirong","family":"Liu","sequence":"first","affiliation":[{"name":"From the Department of Neurology , The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology , Qilu Hospital (Qingdao), Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingjun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology and Research Institute of Neuromuscular and Neurodegenerative Diseases , Qilu Hospital, Shandong University, Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology and Research Institute of Neuromuscular and Neurodegenerative Diseases , Qilu Hospital, Shandong University, Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology and Research Institute of Neuromuscular and Neurodegenerative Diseases , Qilu Hospital, Shandong University, Jinan, Shandong , 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