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Sixteen sheep received a bolus infusion of QA (75\u2009\u00b5L, 180\u2009mM) or saline, first into the left and then (4\u2009weeks later) into the right striatum. Magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) of the striata were performed. Metabolite concentrations and fractional anisotropy (FA) were measured at baseline, acutely (1\u2009week after each surgery) and chronically (5\u2009weeks or greater after the surgeries). There was a significant decrease in the neuronal marker N-acetylaspartate (NAA) and in FA in acutely lesioned striata of the QA-lesioned sheep, followed by a recovery of NAA and FA in the chronically lesioned striata. NAA level changes indicate acute death and\/or impairment of neurons immediately after surgery, with recovery of reversibly impaired neurons over time. The change in FA values of the QA-lesioned striata is consistent with acute structural disruption, followed by re-organization and glial cell infiltration with time. Our study demonstrates that MRS and DTI changes in QA-sheep are consistent with HD-like pathology shown in other model species and that the MR investigations can be performed in sheep using a clinically relevant human 3T MRI scanner.<\/jats:p>","DOI":"10.1093\/jnen\/nlaa053","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T21:11:10Z","timestamp":1596402670000},"page":"1084-1092","source":"Crossref","is-referenced-by-count":6,"title":["Longitudinal Magnetic Resonance Spectroscopy and\u00a0Diffusion Tensor Imaging in Sheep (<i>Ovis aries<\/i>) With Quinolinic Acid Lesions of the Striatum: Time-Dependent Recovery of <i>N-<\/i>Acetylaspartate and Fractional Anisotropy"],"prefix":"10.1093","volume":"79","author":[{"given":"Adam B","family":"O\u2019Connell","sequence":"first","affiliation":[{"name":"Pre-Clinical, Imaging and Research Laboratories (PIRL), South Australia Health and Medical Research Institute (SAHMRI), Adelaide, South 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Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Neumann","sequence":"additional","affiliation":[{"name":"Childhood Dementia Research Group, Hopwood Centre for Neurobiology , SAHMRI, Adelaide, Australia"},{"name":"Childhood Dementia Research Group, College of Medicine and Public Health, Flinders University , Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"Finnie","sequence":"additional","affiliation":[{"name":"Discipline of Anatomy and Pathology, Adelaide Medical School, University of Adelaide and SA Pathology, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M","family":"Hemsley","sequence":"additional","affiliation":[{"name":"Childhood Dementia Research Group, Hopwood Centre for Neurobiology , SAHMRI, Adelaide, Australia"},{"name":"Childhood Dementia Research Group, College of Medicine and Public Health, Flinders University , Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Jennifer","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Physiology, Development and Neuroscience, Cambridge University , Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,2]]},"reference":[{"key":"2024032523340485500_nlaa053-B1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.nbd.2004.07.006","article-title":"Neostriatal and cortical quinolinate levels are increased in early grade Huntington\u2019s disease","volume":"17","author":"Guidetti","year":"2004","journal-title":"Neurobiol Dis"},{"key":"2024032523340485500_nlaa053-B2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.pneurobio.2009.04.005","article-title":"Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington\u2019s 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