{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:04:23Z","timestamp":1782900263816,"version":"3.54.5"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Health and Medical Research Council of Australia","award":["1037746"],"award-info":[{"award-number":["1037746"]}]},{"name":"University of New South Wales and Neuroscience Research Australia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study proposes a practical approach, using the minimum number of brain regions and stains, to consolidate previously published neuropathological criteria into one operationalized schema to differentiate subtypes of frontotemporal lobar degeneration with tau-immunopositive inclusions (FTLD-tau). This approach uses the superior frontal and precentral cortices and hippocampus stained for phosphorylated-tau, p62 and modified Bielschowsky silver, and the midbrain stained only for modified Bielschowsky silver. Accuracy of interrater reliability was determined by 10 raters in 24 FTLD-tau cases (Pick disease = 4, corticobasal degeneration = 9, progressive supranuclear palsy = 5, globular glial tauopathy = 6) including 4 with a mutation in MAPT collected with consent by Sydney Brain Bank. All brain regions and stains assessed proved informative for accurate pathological subtyping, and many neuropathological features were identified as common across the FTLD-tau subtypes. By identifying subtype-specific neuropathological features in the sections selected, 10 independent observers assigned the cases to a FTLD-tau subtype with almost perfect agreement between raters, emphasizing the requirement for the assessment of subtype-specific features for the accurate subtyping of FTLD-tau. This study consolidates current consensus diagnostic criteria for classifying FTLD-tau subtypes with an efficient, simple and accurate approach that can be implemented in future clinicopathological studies.<\/jats:p>","DOI":"10.1093\/jnen\/nlaa100","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T06:25:25Z","timestamp":1600669525000},"page":"1122-1126","source":"Crossref","is-referenced-by-count":2,"title":["A Practical Approach to Differentiate the Frontotemporal Tauopathy Subtypes"],"prefix":"10.1093","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-5389","authenticated-orcid":false,"given":"Shelley L","family":"Forrest","sequence":"first","affiliation":[{"name":"Discipline of Pathology, School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda M","family":"Halliday","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre and Central Clinical School"},{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Neuroscience Research Australia , Sydney, New South Wales, Australia"},{"name":"School of Medical Sciences, University of New South Wales , Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Sizemova","sequence":"additional","affiliation":[{"name":"Discipline of Pathology, School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"van Roijen","sequence":"additional","affiliation":[{"name":"Discipline of Pathology, School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciara V","family":"McGinley","sequence":"additional","affiliation":[{"name":"Discipline of Pathology, School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Bright","sequence":"additional","affiliation":[{"name":"Discipline of Pathology, School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Kapur","sequence":"additional","affiliation":[{"name":"Discipline of Pathology, School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B","family":"McGeachie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Neuroscience Research Australia , Sydney, New South Wales, Australia"},{"name":"School of Medical Sciences, University of New South Wales , Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"McCann","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Neuroscience Research Australia , Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Neuroscience Research Australia , Sydney, New South Wales, Australia"},{"name":"School of Medical Sciences, University of New South Wales , Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel H","family":"Tan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Neuroscience Research Australia , Sydney, New South Wales, Australia"},{"name":"School of Medical Sciences, University of New South Wales , Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Affleck","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Neuroscience Research Australia , Sydney, New South Wales, Australia"},{"name":"School of Medical Sciences, University of New South Wales , Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Huang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Neuroscience Research Australia , Sydney, New South Wales, Australia"},{"name":"School of Medical Sciences, University of New South Wales , Sydney, New South Wales, Australia"},{"name":"China National Clinical Research Centre for Neurological Disorders, Beijing Tiantan Hospital, Capital Medical University , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian J","family":"Kril","sequence":"additional","affiliation":[{"name":"Discipline of Pathology, School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"2024032523351836200_nlaa100-B1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-007-0237-2","article-title":"Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: Consensus of the Consortium for Frontotemporal Lobar Degeneration","volume":"114","author":"Cairns","year":"2007","journal-title":"Acta Neuropathol"},{"key":"2024032523351836200_nlaa100-B2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5414\/NPP29271","article-title":"Current concepts of neuropathological diagnostics in practice: Neurodegenerative diseases","volume":"29","author":"Kovacs","year":"2010","journal-title":"Clin Neuropathol"},{"key":"2024032523351836200_nlaa100-B3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/jnnp-2013-306948","article-title":"New criteria for frontotemporal dementia syndromes: Clinical and pathological diagnostic implications","volume":"85","author":"Chare","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2024032523351836200_nlaa100-B4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00401-013-1171-0","article-title":"Globular glial tauopathies (GGT): Consensus recommendations","volume":"126","author":"Ahmed","year":"2013","journal-title":"Acta Neuropathol"},{"key":"2024032523351836200_nlaa100-B5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/jnen\/61.9.789","article-title":"Severe involvement of ambient gyrus in dementia with grains","volume":"61","author":"Saito","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523351836200_nlaa100-B6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3233\/JAD-171115","article-title":"Argyrophilic grain pathology in frontotemporal lobar degeneration: Demographic, clinical, neuropathological, and genetic features","volume":"63","author":"Gil","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"2024032523351836200_nlaa100-B7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/awx328","article-title":"Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies","volume":"141","author":"Forrest","year":"2018","journal-title":"Brain"},{"key":"2024032523351836200_nlaa100-B8","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/jnen\/61.11.935","article-title":"Office of Rare Diseases neuropathologic criteria for corticobasal degeneration","volume":"61","author":"Dickson","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523351836200_nlaa100-B9","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1212\/WNL.44.11.2015","article-title":"Preliminary NINDS neuropathologic criteria for Steele\u2013Richardson\u2013Olszewski syndrome (progressive supranuclear palsy)","volume":"44","author":"Hauw","year":"1994","journal-title":"Neurology"},{"key":"2024032523351836200_nlaa100-B10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00401-006-0156-7","article-title":"Neurofibrillary tangle-predominant dementia: Comparison with classical Alzheimer disease","volume":"113","author":"Jellinger","year":"2007","journal-title":"Acta Neuropathol"},{"key":"2024032523351836200_nlaa100-B11","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1212\/WNL.56.suppl_4.S16","article-title":"Neuropathology of Pick's disease","volume":"56","author":"Dickson","year":"2001","journal-title":"Neurology"},{"key":"2024032523351836200_nlaa100-B12","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1037\/h0031619","article-title":"Measuring nominal scale agreement among many rater","volume":"76","author":"Fleiss","year":"1971","journal-title":"Psychol Bull"},{"key":"2024032523351836200_nlaa100-B13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"2024032523351836200_nlaa100-B14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00401-011-0839-6","article-title":"Neuropathological background of phenotypical variability in frontotemporal dementia","volume":"122","author":"Josephs","year":"2011","journal-title":"Acta Neuropathol"},{"key":"2024032523351836200_nlaa100-B15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-015-1509-x","article-title":"Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy","volume":"131","author":"Kovacs","year":"2016","journal-title":"Acta Neuropathol"},{"key":"2024032523351836200_nlaa100-B16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1179\/his.1991.14.1.39","article-title":"Rapid, reliable and economical silver staining for neurofibrillary tangles and senile plaques","volume":"14","author":"Garvey","year":"1991","journal-title":"J Histotechnol"},{"key":"2024032523351836200_nlaa100-B17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1901\/jaba.1977.10-103","article-title":"Considerations in the choice of interobserver reliability estimates","volume":"10","author":"Hartmann","year":"1977","journal-title":"J Appl Behav Anal"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/79\/10\/1122\/33892271\/nlaa100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/79\/10\/1122\/33892271\/nlaa100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T23:53:34Z","timestamp":1711410814000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/79\/10\/1122\/5909355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,15]]},"references-count":17,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,9,15]]},"published-print":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlaa100","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,10]]},"published":{"date-parts":[[2020,9,15]]}}}