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The National Institute of Aging convened a meeting to discuss the implications of these observations for research priorities. A summary of the discussion is presented here, with a focus on limitations of current knowledge, highlighting areas that appear to require further investigation in order to guide scientific practice while minimizing potential exposure or risk in the laboratory setting. The committee concluded that, based on all currently available data, although neurodegenerative disease-associated aggregates of several different non-prion proteins can be propagated from humans to experimental animals, there is currently insufficient evidence to suggest more than a negligible risk, if any, of a direct infectious etiology for the human neurodegenerative disorders defined in part by these proteins. Given the importance of this question, the potential for noninvasive human transmission of proteopathic disorders is deserving of further investigation.<\/jats:p>","DOI":"10.1093\/jnen\/nlaa109","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T17:15:30Z","timestamp":1603300530000},"page":"1141-1146","source":"Crossref","is-referenced-by-count":33,"title":["Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns"],"prefix":"10.1093","volume":"79","author":[{"given":"David M","family":"Asher","sequence":"first","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermias","family":"Belay","sequence":"additional","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention , Atlanta, 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