{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:47:15Z","timestamp":1792669635013,"version":"4.5.0"},"reference-count":99,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Long-term diabetic patients suffer immensely from diabetic neuropathy. This study was designed to investigate the effects of hydrogen sulfide (H2S) on peripheral neuropathy, activation of microglia, astrocytes, and the cascade secretion of proinflammatory cytokines in the streptozotocin (STZ)-induced peripheral diabetic neuropathy rat model. STZ-induced diabetic rats were treated with the water-soluble, slow-releasing H2S donor GYY4137 (50\u2009mg\/kg; i.p.) daily for 4\u2009weeks. Antiallodynic\/antihyperalgesic activities were evaluated using different tests and histopathological changes and the expression of proinflammatory cytokines in the spinal cord were examined. GYY4137 treatment produced neuroprotective effects in the spinal cord of diabetic animals and modulated their sensory deficits. The treatment decreased allodynia (p\u2009&amp;lt;\u20090.05) and mechanical hyperalgesia (p\u2009&amp;lt;\u20090.01) and restored thermal hyperalgesia (p\u2009&amp;lt;\u20090.001) compared with diabetic rats. The treatment decreased the microglial response and increased astrocyte counts in spinal cord gray and white matter compared with untreated diabetic rats. Proinflammatory cytokines were reduced in the treated group compared with diabetic rats. These results suggest that H2S has a potentially ameliorative effect on the neuropathic pain through the control of astrocyte activation and microglia-mediated inflammation, which may be considered as a possible treatment of peripheral nerve hypersensitivity in diabetic patients.<\/jats:p>","DOI":"10.1093\/jnen\/nlaa127","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T20:01:57Z","timestamp":1607025717000},"page":"1320-1343","source":"Crossref","is-referenced-by-count":23,"title":["Chronic Treatment With Hydrogen Sulfide Donor GYY4137 Mitigates Microglial and Astrocyte Activation in the Spinal Cord of Streptozotocin-Induced Diabetic Rats"],"prefix":"10.1093","volume":"79","author":[{"given":"Abdulaziz M F","family":"Shayea","sequence":"first","affiliation":[{"name":"Departments of Anatomy, Faculty of Medicine Health Science Center"},{"name":"Occupational Therapy Faculty of Allied Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyaa M A","family":"Mousa","sequence":"additional","affiliation":[{"name":"Departments of Anatomy, Faculty of Medicine Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed M","family":"Renno","sequence":"additional","affiliation":[{"name":"Departments of Anatomy, Faculty of Medicine Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Shaban","family":"Nadar","sequence":"additional","affiliation":[{"name":"Occupational Therapy Faculty of Allied Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bedoor","family":"Qabazard","sequence":"additional","affiliation":[{"name":"Pharmacology and Therapeutics, Faculty of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam H M","family":"Yousif","sequence":"additional","affiliation":[{"name":"Pharmacology & Toxicology Department, Faculty of Medicine (MHMY), Kuwait University , Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"2024032523371784100_nlaa127-B1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.2337\/dc10-2177","article-title":"Medical expenditures associated with diabetes among privately insured US youth in 2007","volume":"34","author":"Shrestha","year":"2011","journal-title":"Diabetes Care"},{"key":"2024032523371784100_nlaa127-B2","first-page":"541","article-title":"Classification, pathophysiology, diagnosis and management of diabetes mellitus","volume":"6","author":"Baynes","year":"2015","journal-title":"J Diabetes Metab"},{"key":"2024032523371784100_nlaa127-B3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jns5.12072","article-title":"Phenotyping animal models of diabetic neuropathy: A consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab)","volume":"19","author":"Biessels","year":"2014","journal-title":"J Peripher Nerv Syst"},{"key":"2024032523371784100_nlaa127-B4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/pgmj.2005.036137","article-title":"Diabetic neuropathy","volume":"82","author":"Bansal","year":"2006","journal-title":"Postgrad Med J"},{"key":"2024032523371784100_nlaa127-B5","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/dc10-1303","article-title":"Diabetic neuropathies: Update on definitions, diagnostic criteria, estimation of severity, and treatments","volume":"33","author":"Tesfaye","year":"2010","journal-title":"Diabetes Care"},{"key":"2024032523371784100_nlaa127-B6","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.nurt.2009.07.004","article-title":"Diabetic painful and insensate neuropathy: Pathogenesis and potential treatments","volume":"6","author":"Obrosova","year":"2009","journal-title":"Neurotherapeutics"},{"key":"2024032523371784100_nlaa127-B7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/157015906778019536","article-title":"Painful peripheral neuropathies","volume":"4","author":"Marchettini","year":"2006","journal-title":"Curr Neuropharmacol"},{"key":"2024032523371784100_nlaa127-B8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The glial nature of embryonic and adult neural stem cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"2024032523371784100_nlaa127-B9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4110\/in.2012.12.2.41","article-title":"Glia as a link between neuroinflammation and neuropathic pain","volume":"12","author":"Jha","year":"2012","journal-title":"Immune Netw"},{"key":"2024032523371784100_nlaa127-B10","first-page":"136","article-title":"Role of proinflammatory cytokines released from microglia in Alzheimer's disease","volume":"3","author":"Wang","year":"2015","journal-title":"Ann Transl Med"},{"key":"2024032523371784100_nlaa127-B11","doi-asserted-by":"crossref","first-page":"12029","DOI":"10.1038\/ncomms12029","article-title":"Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury","volume":"7","author":"Peng","year":"2016","journal-title":"Nat Commun"},{"key":"2024032523371784100_nlaa127-B12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/jdi.12379","article-title":"Microglia in the spinal cord and neuropathic pain","volume":"7","author":"Tsuda","year":"2016","journal-title":"J Diabetes Invest"},{"key":"2024032523371784100_nlaa127-B13","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s40478-014-0142-6","article-title":"Microglial pathology","volume":"2","author":"Streit","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"2024032523371784100_nlaa127-B14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(01)01311-5","article-title":"Involvement of chemokines in pain","volume":"429","author":"Boddeke","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"2024032523371784100_nlaa127-B15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.expneurol.2011.08.018","article-title":"The mechanisms of microgliosis and pain following peripheral nerve injury","volume":"234","author":"Calvo","year":"2012","journal-title":"Exp Neurol"},{"key":"2024032523371784100_nlaa127-B16","first-page":"11","article-title":"Centralized pain: Our new clinical challenge","volume":"1","author":"Tennant","year":"2013","journal-title":"Pain"},{"key":"2024032523371784100_nlaa127-B17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2014.01.057","article-title":"Activated microglia in the spinal cord underlies diabetic neuropathic pain","volume":"728","author":"Wang","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"2024032523371784100_nlaa127-B18","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1089\/ars.2006.8.661","article-title":"Hydrogen sulfide protects HT22 neuronal cells from oxidative stress","volume":"8","author":"Kimura","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"2024032523371784100_nlaa127-B19","doi-asserted-by":"crossref","first-page":"28827","DOI":"10.1074\/jbc.M114.596593","article-title":"Hydrogen sulfide alleviates diabetic nephropathy in a streptozotocin-induced diabetic rat model","volume":"289","author":"Zhou","year":"2014","journal-title":"J Biol Chem"},{"key":"2024032523371784100_nlaa127-B20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2015.10.029","article-title":"Is there a role for neurotrophic factors and their receptors in augmenting the neuroprotective effect of (\u2013)-epigallocatechin-3-gallate treatment of sciatic nerve crush injury?","volume":"102","author":"Renno","year":"2016","journal-title":"Neuropharmacology"},{"key":"2024032523371784100_nlaa127-B21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3171\/2016.10.SPINE16218","article-title":"Possible role of antioxidative capacity of (\u2013)-epigallocatechin-3-gallate treatment in morphological and neurobehavioral recovery after sciatic nerve crush injury","volume":"27","author":"Renno","year":"2017","journal-title":"J Neurosurg Spine"},{"key":"2024032523371784100_nlaa127-B22","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"2024032523371784100_nlaa127-B23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.phrs.2012.05.001","article-title":"Characterization of Angiotensin-(1\u20137) effects on the cardiovascular system in an experimental model of Type-1 diabetes","volume":"66","author":"Yousif","year":"2012","journal-title":"Pharmacological Research"},{"key":"2024032523371784100_nlaa127-B24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41443-018-0083-x","article-title":"Alleviation of impaired reactivity in the corpus cavernosum of STZ-diabetic rats by slow-release H2S donor GYY4137","volume":"31","author":"Qabazard","year":"2019","journal-title":"Int J Impot Res"},{"key":"2024032523371784100_nlaa127-B25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/10284150600576705","article-title":"Green tea pain modulating effect in sciatic nerve chronic constriction injury rat model","volume":"9","author":"Renno","year":"2006","journal-title":"Nutr Neurosci"},{"key":"2024032523371784100_nlaa127-B26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"2024032523371784100_nlaa127-B27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/neu.1997.14.517","article-title":"Chronic central pain after spinal cord injury","volume":"14","author":"Christensen","year":"1997","journal-title":"J Neurotrauma"},{"key":"2024032523371784100_nlaa127-B28","first-page":"A149","article-title":"Changes in inflammatory mediators in DRG of type 1 diabetic animals with neuropathy","volume":"63","author":"Yoon","year":"2014","journal-title":"Diabetes"},{"key":"2024032523371784100_nlaa127-B29","doi-asserted-by":"crossref","first-page":"e0226626","DOI":"10.1371\/journal.pone.0226626","article-title":"Neurotherapeutic effects of ginkgo biloba extract and its terpene trilactone, ginkgolide B, on sciatic crush injury model: A new evidence","volume":"14","author":"Al-Adwani","year":"2019","journal-title":"PLoS One"},{"key":"2024032523371784100_nlaa127-B30","first-page":"1","article-title":"Psychopharmacology of clonidine: An introduction","volume":"71","author":"Lal","year":"1981","journal-title":"Prog Clin Biol Res"},{"key":"2024032523371784100_nlaa127-B31","first-page":"233","article-title":"Archives Internationales de Pharmacodynamie et de","volume":"133","author":"Randall","year":"1957","journal-title":"Th\u00e9rapie (Hashi Trust)"},{"key":"2024032523371784100_nlaa127-B32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1089\/neu.2014.3491","article-title":"(\u2013)-Epigallocatechin-3-gallate modulates spinal cord neuronal degeneration by enhancing growth-associated protein 43, B-cell lymphoma 2, and decreasing B-cell lymphoma 2-associated x protein expression after sciatic nerve crush injury","volume":"32","author":"Renno","year":"2015","journal-title":"J Neurotrauma"},{"key":"2024032523371784100_nlaa127-B33","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.neuroscience.2008.08.010","article-title":"Influences of surgical decompression on the dorsal horn after chronic constriction injury: Changes in peptidergic and delta-opioid receptor (+) nerve terminals","volume":"156","author":"Tseng","year":"2008","journal-title":"Neuroscience"},{"key":"2024032523371784100_nlaa127-B34","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00198-016-3756-7","article-title":"Treatment with hydrogen sulfide attenuates sublesional skeletal deterioration following motor complete spinal cord injury in rats","volume":"28","author":"Yang","year":"2017","journal-title":"Osteoporos Int"},{"key":"2024032523371784100_nlaa127-B35","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/SHK.0b013e3181cdc4ae","article-title":"Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release","volume":"34","author":"Xie","year":"2010","journal-title":"Shock"},{"key":"2024032523371784100_nlaa127-B36","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1590\/1414-431X20143949","article-title":"Propofol pretreatment attenuates lipopolysaccharide-induced acute lung injury in rats by activating the phosphoinositide-3-kinase\/Akt pathway","volume":"47","author":"Zhao","year":"2014","journal-title":"Braz J Med Biol Res"},{"key":"2024032523371784100_nlaa127-B37","doi-asserted-by":"crossref","first-page":"106836","DOI":"10.1155\/2015\/106836","article-title":"Protective effects of hydrogen-rich saline on rats with smoke inhalation injury","volume":"2015","author":"Chen","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"2024032523371784100_nlaa127-B38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.phrs.2016.08.019","article-title":"The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro","volume":"113","author":"Ger\u0151","year":"2016","journal-title":"Pharmacol Res"},{"key":"2024032523371784100_nlaa127-B39","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1038\/s41598-017-03941-0","article-title":"A long-term and slow-releasing hydrogen sulfide donor protects against myocardial ischemia\/reperfusion injury","volume":"7","author":"Sun","year":"2017","journal-title":"Sci Rep"},{"key":"2024032523371784100_nlaa127-B40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/hr.2014.125","article-title":"Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice","volume":"38","author":"Al-Magableh","year":"2015","journal-title":"Hypertens Res"},{"key":"2024032523371784100_nlaa127-B41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.niox.2014.04.006","article-title":"Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer","volume":"41","author":"Elsheikh","year":"2014","journal-title":"Nitric Oxide"},{"key":"2024032523371784100_nlaa127-B42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/jcmm.12405","article-title":"Hydrogen sulphide decreases IL-1beta-induced activation of fibroblast-like synoviocytes from patients with osteoarthritis","volume":"19","author":"Sieghart","year":"2015","journal-title":"J Cell Mol Med"},{"key":"2024032523371784100_nlaa127-B43","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1053\/j.gastro.2009.04.012","article-title":"Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats","volume":"137","author":"Wallace","year":"2009","journal-title":"Gastroenterology"},{"key":"2024032523371784100_nlaa127-B44","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2337\/db16-0020","article-title":"Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation","volume":"65","author":"Xie","year":"2016","journal-title":"Diabetes"},{"key":"2024032523371784100_nlaa127-B45","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/CS20140460","article-title":"Hydrogen sulfide attenuates the development of diabetic cardiomyopathy","volume":"128","author":"Zhou","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"2024032523371784100_nlaa127-B46","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbalip.2017.11.008","article-title":"Cystathionine gamma-lyase\/hydrogen sulfide system is essential for adipogenesis and fat mass accumulation in mice","volume":"1863","author":"Yang","year":"2018","journal-title":"Biochim Biophys Acta"},{"key":"2024032523371784100_nlaa127-B47","doi-asserted-by":"crossref","first-page":"e0119511","DOI":"10.1371\/journal.pone.0119511","article-title":"Hydrogen sulfide promotes adipogenesis in 3T3L1 cells","volume":"10","author":"Tsai","year":"2015","journal-title":"PLoS One"},{"key":"2024032523371784100_nlaa127-B48","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbalip.2016.03.001","article-title":"Cystathionine gamma lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor gamma activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes","volume":"1861","author":"Cai","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"2024032523371784100_nlaa127-B49","doi-asserted-by":"crossref","first-page":"e73892","DOI":"10.1371\/journal.pone.0073892","article-title":"Increase or decrease hydrogen sulfide exert opposite lipolysis, but reduce global insulin resistance in high fatty diet induced obese mice","volume":"8","author":"Geng","year":"2013","journal-title":"PLoS One"},{"key":"2024032523371784100_nlaa127-B50","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11010-013-1946-6","article-title":"GYY4137, a novel hydrogen sulfide-releasing molecule, likely protects against high glucose-induced cytotoxicity by activation of the AMPK\/mTOR signal pathway in H9c2 cells","volume":"389","author":"Wei","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"2024032523371784100_nlaa127-B51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1089\/ars.2011.4451","article-title":"Roles of hydrogen sulfide in the pathogenesis of diabetes mellitus and its complications","volume":"17","author":"Szabo","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"2024032523371784100_nlaa127-B52","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0918s29","article-title":"Animal models of painful diabetic neuropathy: The STZ rat model","author":"Morrow","year":"2004","journal-title":"Curr Protoc Neurosci"},{"key":"2024032523371784100_nlaa127-B53","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jep.2008.07.049","article-title":"Ameliorative effects of Ocimum sanctum in sciatic nerve transection-induced neuropathy in rats","volume":"120","author":"Muthuraman","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"2024032523371784100_nlaa127-B54","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.2337\/diab.37.9.1253","article-title":"Effect of hyperglycemia on pain perception and on efficacy of morphine analgesia in rats","volume":"37","author":"Raz","year":"1988","journal-title":"Diabetes"},{"key":"2024032523371784100_nlaa127-B55","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4103\/0250-474X.100235","article-title":"Effect of fluoxetine on an experimental model of diabetes-induced neuropathic pain perception in the rat Indian","volume":"73","author":"Tembhurne","year":"2011","journal-title":"Indian J Pharm Sci"},{"key":"2024032523371784100_nlaa127-B56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/bja\/aen088","article-title":"Spinal cord mechanisms of pain BJA","volume":"101","author":"D\u2019Mello","year":"2008","journal-title":"Br J Anaesth"},{"key":"2024032523371784100_nlaa127-B57","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/j.1460-9568.1995.tb01134.x","article-title":"Flip and Flop variants of AMPA receptors in the rat lumbar spinal cord","volume":"7","author":"T\u00f6lle","year":"1995","journal-title":"Eur J Neurosci"},{"key":"2024032523371784100_nlaa127-B58","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pneurobio.2008.06.002","article-title":"Nociceptive behavior in animal models for peripheral neuropathy: Spinal and supraspinal mechanisms","volume":"86","author":"Saad\u00e9","year":"2008","journal-title":"Prog in Neurobiol"},{"key":"2024032523371784100_nlaa127-B59","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/jir.1996.16.695","article-title":"Interleukin-6-mediated hyperalgesia\/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model","volume":"16","author":"Deleo","year":"1996","journal-title":"J Interferon Cytokine Res"},{"key":"2024032523371784100_nlaa127-B60","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/00000542-200510000-00023","article-title":"Role for cyclooxygenase 2 in the development and maintenance of neuropathic pain and spinal glial activation","volume":"103","author":"Takeda","year":"2005","journal-title":"Anesthesiol"},{"key":"2024032523371784100_nlaa127-B61","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.pain.2005.12.023","article-title":"Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury","volume":"121","author":"Piao","year":"2006","journal-title":"Pain"},{"key":"2024032523371784100_nlaa127-B62","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ejphar.2007.01.013","article-title":"Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain","volume":"560","author":"Mika","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"2024032523371784100_nlaa127-B63","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3959(00)00386-9","article-title":"Spinal and supraspinal components of opioid antinociception in streptozotocin-induced diabetic neuropathy in rats","volume":"90","author":"Zurek","year":"2001","journal-title":"Pain"},{"key":"2024032523371784100_nlaa127-B64","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0306-4522(02)00111-2","article-title":"Attenuation of neuropathic pain by segmental and supraspinal activation of the dorsal column system in awake rats","volume":"112","author":"El-Khoury","year":"2002","journal-title":"Neuroscience"},{"key":"2024032523371784100_nlaa127-B65","doi-asserted-by":"crossref","first-page":"174480691772455","DOI":"10.1177\/1744806917724559","article-title":"Immune system involvement in specific pain conditions","volume":"13","author":"Totsch","year":"2017","journal-title":"Mol Pain"},{"key":"2024032523371784100_nlaa127-B66","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: A unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"2024032523371784100_nlaa127-B67","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.2337\/db11-0026","article-title":"Intervention with an erythropoietin-derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathy","volume":"60","author":"McVicar","year":"2011","journal-title":"Diabetes"},{"key":"2024032523371784100_nlaa127-B68","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/archophthalmol.2007.65","article-title":"Microglial activation in human diabetic retinopathy","volume":"126","author":"Zeng","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"2024032523371784100_nlaa127-B69","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12974-015-0421-6","article-title":"Altered morphological dynamics of activated microglia after induction of status epilepticus","volume":"12","author":"Avignone","year":"2015","journal-title":"J Neuroinflam"},{"key":"2024032523371784100_nlaa127-B70","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/emm.2006.40","article-title":"Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinson's disease","volume":"38","author":"Kim","year":"2006","journal-title":"Exp Mol Med"},{"key":"2024032523371784100_nlaa127-B71","doi-asserted-by":"crossref","first-page":"9513","DOI":"10.1038\/srep09513","article-title":"Phenotypic dysregulation of microglial activation in young offspring rats with maternal sleep deprivation-induced cognitive impairment","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci Rep"},{"key":"2024032523371784100_nlaa127-B72","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.brainresrev.2006.11.002","article-title":"The origin and cell lineage of microglia: New concepts","volume":"53","author":"Chan","year":"2007","journal-title":"Brain Res Rev"},{"key":"2024032523371784100_nlaa127-B73","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/ecp.10.134","article-title":"Hydrogen sulfide and inflammation: The good, the bad, the ugly and the promising","volume":"4","author":"Whiteman","year":"2011","journal-title":"Expert Rev Clin Pharmacol"},{"key":"2024032523371784100_nlaa127-B74","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ejcts.2008.01.047","article-title":"The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury","volume":"33","author":"Sodha","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"key":"2024032523371784100_nlaa127-B75","doi-asserted-by":"crossref","first-page":"174480691664678","DOI":"10.1177\/1744806916646784","article-title":"Interleukin-1beta overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents","volume":"12","author":"Gui","year":"2016","journal-title":"Mol Pain"},{"key":"2024032523371784100_nlaa127-B76","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1128\/IAI.01428-07","article-title":"Interleukin-1beta modulates proinflammatory cytokine production in human epithelial cells","volume":"76","author":"Eskan","year":"2008","journal-title":"Infect Immun"},{"key":"2024032523371784100_nlaa127-B77","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12950-016-0119-2","article-title":"Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin but does not play a role in the development of endotoxin tolerance","volume":"13","author":"Rios","year":"2016","journal-title":"J Inflamm (Lond)"},{"key":"2024032523371784100_nlaa127-B78","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12974-016-0607-6","article-title":"Interleukin-6: An emerging regulator of pathological pain","volume":"13","author":"Zhou","year":"2016","journal-title":"J Neuroinflam"},{"key":"2024032523371784100_nlaa127-B79","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bbi.2006.10.010","article-title":"Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120","volume":"21","author":"Schoeniger-Skinner","year":"2007","journal-title":"Brain Behav Immun"},{"key":"2024032523371784100_nlaa127-B80","first-page":"929","article-title":"Platycodin D inhibits inflammatory response in LPS-stimulated primary rat microglia cells through activating LXR\u03b1-ABCA1 signaling pathway","volume":"8","author":"Fu","year":"2017","journal-title":"Front Immunol"},{"key":"2024032523371784100_nlaa127-B81","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1179\/147683008X301405","article-title":"Consumption of green tea alters glial fibrillary acidic protein immunoreactivity in the spinal cord astrocytes of STZ-diabetic rats","volume":"11","author":"Renno","year":"2008","journal-title":"Nutr Neurosci"},{"key":"2024032523371784100_nlaa127-B82","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/glia.20068","article-title":"Effects of diabetes mellitus on astrocyte GFAP and glutamate transporters in the CNS","volume":"48","author":"Coleman","year":"2004","journal-title":"Glia"},{"key":"2024032523371784100_nlaa127-B83","first-page":"1971","article-title":"Glial reactivity, an early feature of diabetic retinopathy","volume":"41","author":"Rungger-Brandle","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024032523371784100_nlaa127-B84","doi-asserted-by":"crossref","first-page":"506","DOI":"10.2337\/diabetes.52.2.506","article-title":"A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat","volume":"52","author":"Asnaghi","year":"2003","journal-title":"Diabetes"},{"key":"2024032523371784100_nlaa127-B85","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00005072-199305000-00002","article-title":"Neuronal and glial gene expression in neocortex of Down\u2019s syndrome and Alzheimer\u2019s disease","volume":"52","author":"Goodison","year":"1993","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523371784100_nlaa127-B86","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11068-005-5044-x","article-title":"Changes in mitotic rate and GFAP expression in the primary olfactory axis of streptozotocin-induced diabetic rats","volume":"34","author":"Dennis","year":"2005","journal-title":"J Neurocytol"},{"key":"2024032523371784100_nlaa127-B87","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1056-8727(96)90006-9","article-title":"Cerebrovascular disorders in patients with diabetes mellitus","volume":"10","author":"Mankovsky","year":"1996","journal-title":"J Diabetes Complications"},{"key":"2024032523371784100_nlaa127-B88","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2174\/1381612033455314","article-title":"Effect of diabetes on the blood-brain barrier","volume":"9","author":"Horani","year":"2003","journal-title":"Curr Pharm Des"},{"key":"2024032523371784100_nlaa127-B89","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1073\/pnas.93.13.6361","article-title":"Targeted deletion in astrocyte intermediate filament (GFAP) alters neuronal physiology","volume":"93","author":"McCall","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024032523371784100_nlaa127-B90","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/2070","article-title":"Impaired blood-brain barrier function in angiotensinogen-deficient mice","volume":"4","author":"Kakinuma","year":"1998","journal-title":"Nat Med"},{"key":"2024032523371784100_nlaa127-B91","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1469-7580.2002.00064.x","article-title":"Astrocyte-endothelial interactions and blood-brain barrier permeability","volume":"200","author":"Abbott","year":"2002","journal-title":"J Anatomy"},{"key":"2024032523371784100_nlaa127-B92","first-page":"3561","article-title":"Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes","volume":"41","author":"Barber","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024032523371784100_nlaa127-B93","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0006-8993(91)90781-P","article-title":"Insulin influences astroglial morphology and glial fibrillary acidic protein (GFAP) expression in organotypic cultures","volume":"558","author":"Toran-Allerand","year":"1991","journal-title":"Brain Res"},{"key":"2024032523371784100_nlaa127-B94","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0006-8993(00)02212-5","article-title":"Oxidative stress and HNE conjugation of GLUT3 are increased in the hippocampus of diabetic rats subjected to stress","volume":"862","author":"Reagan","year":"2000","journal-title":"Brain Res"},{"key":"2024032523371784100_nlaa127-B95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/674987","article-title":"Neuroinflammation and oxidative stress in diabetic neuropathy: Futuristic strategies based on these targets","volume":"2014","author":"Sandireddy","year":"2014","journal-title":"Int J Endocrinol"},{"key":"2024032523371784100_nlaa127-B96","doi-asserted-by":"crossref","first-page":"738","DOI":"10.2174\/1381612822666151204001234","article-title":"Evolving insights into the pathophysiology of diabetic neuropathy: Implications of malfunctioning glia and discovery of novel therapeutic targets","volume":"22","author":"Rahman","year":"2016","journal-title":"Curr Pharm Des"},{"key":"2024032523371784100_nlaa127-B97","first-page":"45","article-title":"Type 2 diabetes mellitus, oxidative stress and inflammation: Examining the links","volume":"11","author":"Oguntibeju","year":"2019","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"2024032523371784100_nlaa127-B98","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41419-017-0135-z","article-title":"Cellular death, reactive oxygen species (ROS) and diabetic complications","volume":"9","author":"Volpe","year":"2018","journal-title":"Cell Death Dis"},{"key":"2024032523371784100_nlaa127-B99","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10735-010-9271-9","article-title":"Apoptotic factors (Bcl-2 and Bax) and diabetic retinopathy in type 2 diabetes","volume":"41","author":"Khalfaoui","year":"2010","journal-title":"J Mol Hist"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/79\/12\/1320\/34693057\/nlaa127.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/79\/12\/1320\/34693057\/nlaa127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T23:58:12Z","timestamp":1711411092000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/79\/12\/1320\/6019882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,26]]},"references-count":99,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,11,26]]},"published-print":{"date-parts":[[2020,12,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlaa127","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12]]},"published":{"date-parts":[[2020,11,26]]}}}