{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:07:08Z","timestamp":1785499628939,"version":"3.56.0"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS107417"],"award-info":[{"award-number":["R01NS107417"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS113921"],"award-info":[{"award-number":["R01NS113921"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS109029"],"award-info":[{"award-number":["R01NS109029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS060703"],"award-info":[{"award-number":["R01NS060703"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Heart Association Transformational Project Award"},{"name":"DeGeorge Charitable Trust","award":["18TPA34170077"],"award-info":[{"award-number":["18TPA34170077"]}]},{"name":"Johns Hopkins University Alzheimer\u2019s Disease Research Center","award":["AG005146"],"award-info":[{"award-number":["AG005146"]}]},{"name":"Pearl M. Stetler Fellowship Award"},{"name":"Thrasher Research Fund Early Career Award Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neonatal hypoxia-ischemia (HI) causes white matter injury that is not fully prevented by therapeutic hypothermia. Adjuvant treatments are needed. We compared myelination in different piglet white matter regions. We then tested whether oleuropein (OLE) improves neuroprotection in 2- to 4-day-old piglets randomized to undergo HI or sham procedure and OLE or vehicle administration beginning at 15\u2009minutes. All groups received overnight hypothermia and rewarming. Injury in the subcortical white matter, corpus callosum, internal capsule, putamen, and motor cortex gray matter was assessed 1\u2009day later. At baseline, piglets had greater subcortical myelination than in corpus callosum. Hypothermic HI piglets had scant injury in putamen and cerebral cortex. However, hypothermia alone did not prevent the loss of subcortical myelinating oligodendrocytes or the reduction in subcortical myelin density after HI. Combining OLE with hypothermia improved post-HI subcortical white matter protection by preserving myelinating oligodendrocytes, myelin density, and oligodendrocyte markers. Corpus callosum and internal capsule showed little HI injury after hypothermia, and OLE accordingly had minimal effect. OLE did not affect putamen or motor cortex neuron counts. Thus, OLE combined with hypothermia protected subcortical white matter after HI. As an adjuvant to hypothermia, OLE may subacutely improve regional white matter protection after HI.<\/jats:p>","DOI":"10.1093\/jnen\/nlaa132","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T23:48:32Z","timestamp":1605916112000},"page":"182-198","source":"Crossref","is-referenced-by-count":8,"title":["Combining Hypothermia and Oleuropein Subacutely Protects Subcortical White Matter in a Swine Model of Neonatal Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1093","volume":"80","author":[{"given":"Jennifer K","family":"Lee","sequence":"first","affiliation":[{"name":"From the Department of Anesthesiology and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polan T","family":"Santos","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May W","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Kulikowicz","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Adams","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Hardart","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C","family":"Koehler","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology and Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee J","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"2024032523364526300_nlaa132-B1","first-page":"409","article-title":"No cry at birth: Global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths","volume":"83","author":"Lawn","year":"2005","journal-title":"Bull World Health Organ"},{"key":"2024032523364526300_nlaa132-B2","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","article-title":"Global, regional, and national causes of child mortality: An updated systematic analysis for 2010 with time trends since 2000","volume":"379","author":"Liu","year":"2012","journal-title":"Lancet"},{"key":"2024032523364526300_nlaa132-B3","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"2024032523364526300_nlaa132-B4","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N Engl J Med"},{"key":"2024032523364526300_nlaa132-B5","first-page":"F398","article-title":"Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy","volume":"97","author":"Shankaran","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2024032523364526300_nlaa132-B6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000452833","article-title":"Optimizing cerebral autoregulation may decrease neonatal regional hypoxic-ischemic brain injury","volume":"39","author":"Lee","year":"2017","journal-title":"Dev Neurosci"},{"key":"2024032523364526300_nlaa132-B7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3174\/ajnr.A4083","article-title":"Apparent diffusion coefficient scalars correlate with near-infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-ischemic injury","volume":"36","author":"Tekes","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024032523364526300_nlaa132-B8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijdevneu.2014.06.007","article-title":"The effects of hypoxic preconditioning on white matter damage following hypoxic-ischaemic injury in the neonatal rat brain","volume":"37","author":"Suryana","year":"2014","journal-title":"Int J Dev Neurosci"},{"key":"2024032523364526300_nlaa132-B9","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/iub.189","article-title":"Oxidized proteins: Mechanisms of removal and consequences of accumulation","volume":"61","author":"Dunlop","year":"2009","journal-title":"IUBMB Life"},{"key":"2024032523364526300_nlaa132-B10","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1523\/JNEUROSCI.1307-04.2004","article-title":"Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture","volume":"24","author":"Goldbaum","year":"2004","journal-title":"J Neurosci"},{"key":"2024032523364526300_nlaa132-B11","first-page":"162","article-title":"Endoplasmic reticulum protein quality control failure in myelin disorders","volume":"9","author":"Volpi","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"2024032523364526300_nlaa132-B12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3945\/an.116.013243","article-title":"Early-life nutrition and neurodevelopment: Use of the piglet as a translational model","volume":"8","author":"Mudd","year":"2017","journal-title":"Adv Nutr"},{"key":"2024032523364526300_nlaa132-B13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1471-4159.1976.tb12256.x","article-title":"Biphasic myelination and the fatty acid composition of cerebrosides and cholesterol esters in the developing central nervous system of the domestic pig","volume":"27","author":"Sweasey","year":"1976","journal-title":"J Neurochem"},{"key":"2024032523364526300_nlaa132-B14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.braindev.2018.10.009","article-title":"Correlation between human nervous system development and acquisition of fetal skills: An overview","volume":"41","author":"Borsani","year":"2019","journal-title":"Brain Dev"},{"key":"2024032523364526300_nlaa132-B15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroimage.2018.06.018","article-title":"Construction of a neonatal cortical surface atlas using Multimodal Surface Matching in the Developing Human Connectome Project","volume":"179","author":"Bozek","year":"2018","journal-title":"Neuroimage"},{"key":"2024032523364526300_nlaa132-B16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.earlhumdev.2005.10.013","article-title":"Ontogeny of the human central nervous system: What is happening when?","volume":"82","author":"de Graaf-Peters","year":"2006","journal-title":"Early Hum Dev"},{"key":"2024032523364526300_nlaa132-B17","doi-asserted-by":"crossref","first-page":"e009415","DOI":"10.1161\/JAHA.118.009415","article-title":"Proteasome biology is compromised in white matter after asphyxic cardiac arrest in neonatal piglets","volume":"7","author":"Santos","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2024032523364526300_nlaa132-B18","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/(SICI)1096-9861(19970113)377:2<262::AID-CNE8>3.0.CO;2-1","article-title":"Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia","volume":"377","author":"Martin","year":"1997","journal-title":"J Comp Neurol"},{"key":"2024032523364526300_nlaa132-B19","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1177\/0271678X18797328","article-title":"Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy","volume":"38","author":"Koehler","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"key":"2024032523364526300_nlaa132-B20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum Dev"},{"key":"2024032523364526300_nlaa132-B21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/mnfr.201100436","article-title":"Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake","volume":"56","author":"Serra","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"2024032523364526300_nlaa132-B22","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.pharep.2017.05.004","article-title":"Oleuropein protects intracerebral hemorrhage-induced disruption of blood-brain barrier through alleviation of oxidative stress","volume":"69","author":"Shi","year":"2017","journal-title":"Pharmacol Rep"},{"key":"2024032523364526300_nlaa132-B23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejmech.2019.03.009","article-title":"Therapeutic potentials of plant iridoids in Alzheimer\u2019s and Parkinson\u2019s diseases: A review","volume":"169","author":"Dinda","year":"2019","journal-title":"Eur J Med Chem"},{"key":"2024032523364526300_nlaa132-B24","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3390\/ijms17081293","article-title":"Oleuropein prevents neuronal death, mitigates mitochondrial superoxide production and modulates autophagy in a dopaminergic cellular model","volume":"17","author":"Achour","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2024032523364526300_nlaa132-B25","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2174\/092986709787581860","article-title":"Proteasome regulators: Activators and inhibitors","volume":"16","author":"Huang","year":"2009","journal-title":"Curr Med Chem"},{"key":"2024032523364526300_nlaa132-B26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00210-016-1323-6","article-title":"Oleuropein attenuates the progression of heart failure in rats by antioxidant and antiinflammatory effects","volume":"390","author":"Janahmadi","year":"2017","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2024032523364526300_nlaa132-B27","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/sj.ejcn.1602724","article-title":"Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: A randomized, crossover, controlled trial","volume":"62","author":"Fito","year":"2008","journal-title":"Eur J Clin Nutr"},{"key":"2024032523364526300_nlaa132-B28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1017\/S0007114515001269","article-title":"Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: A randomised, double-blind, placebo-controlled, cross-over trial","volume":"114","author":"Lockyer","year":"2015","journal-title":"Br J Nutr"},{"key":"2024032523364526300_nlaa132-B29","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00394-016-1188-y","article-title":"Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: A randomised controlled trial","volume":"56","author":"Lockyer","year":"2017","journal-title":"Eur J Nutr"},{"key":"2024032523364526300_nlaa132-B30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2174\/1573406413666170906123204","article-title":"Myelin oligodendrocyte glycoprotein and multiple sclerosis","volume":"14","author":"Androutsou","year":"2018","journal-title":"Med Chem"},{"key":"2024032523364526300_nlaa132-B31","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/jcbfm.2014.245","article-title":"Rewarming from therapeutic hypothermia induces cortical neuron apoptosis in a swine model of neonatal hypoxic-ischemic encephalopathy","volume":"35","author":"Wang","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"2024032523364526300_nlaa132-B32","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1152\/japplphysiol.00238.2013","article-title":"Cerebrovascular autoregulation after rewarming from hypothermia in a neonatal swine model of asphyxic brain injury","volume":"115","author":"Larson","year":"2013","journal-title":"J Appl Physiol (1985)"},{"key":"2024032523364526300_nlaa132-B33","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1097\/PCC.0000000000001299","article-title":"End-tidal CO2-guided chest compression delivery improves survival in a neonatal asphyxial cardiac arrest model","volume":"18","author":"Hamrick","year":"2017","journal-title":"Pediatr Crit Care Med"},{"key":"2024032523364526300_nlaa132-B34","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.2527\/jas.2012-5501","article-title":"Piglet behavior as a measure of vitality and its influence on piglet survival and growth during lactation","volume":"91","author":"Muns","year":"2013","journal-title":"J Anim Sci"},{"key":"2024032523364526300_nlaa132-B35","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.prevetmed.2012.11.016","article-title":"Newborn piglet traits associated with survival and growth performance until weaning","volume":"110","author":"Panzardi","year":"2013","journal-title":"Prev Vet Med"},{"key":"2024032523364526300_nlaa132-B36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1203\/01.PDR.0000072783.22373.FF","article-title":"Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming","volume":"54","author":"Agnew","year":"2003","journal-title":"Pediatr Res"},{"key":"2024032523364526300_nlaa132-B37","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00005072-195312040-00008","article-title":"A method for the combined staining of cells and fibers in the nervous system","volume":"12","author":"Kluver","year":"1953","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523364526300_nlaa132-B38","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3174\/ajnr.A5168","article-title":"Myelin detection using rapid quantitative MR imaging correlated to macroscopically registered luxol fast blue-stained brain specimens","volume":"38","author":"Warntjes","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024032523364526300_nlaa132-B39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuroscience.2015.12.046","article-title":"White matter apoptosis is increased by delayed hypothermia and rewarming in a neonatal piglet model of hypoxic ischemic encephalopathy","volume":"316","author":"Wang","year":"2016","journal-title":"Neuroscience"},{"key":"2024032523364526300_nlaa132-B40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13024-016-0124-1","article-title":"Predominant expression of Alzheimer\u2019s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts","volume":"11","author":"De Rossi","year":"2016","journal-title":"Mol Neurodegener"},{"key":"2024032523364526300_nlaa132-B41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000496602","article-title":"Hypoxia-ischemia and hypothermia independently and interactively affect neuronal pathology in neonatal piglets with short-term recovery","volume":"41","author":"O\u2019Brien","year":"2019","journal-title":"Dev Neurosci"},{"key":"2024032523364526300_nlaa132-B42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0361-9230(98)00024-0","article-title":"Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis","volume":"46","author":"Martin","year":"1998","journal-title":"Brain Res Bull"},{"key":"2024032523364526300_nlaa132-B43","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000448585","article-title":"Hypothermia and rewarming activate a macroglial unfolded protein response independent of hypoxic-ischemic brain injury in neonatal piglets","volume":"38","author":"Lee","year":"2016","journal-title":"Dev Neurosci"},{"key":"2024032523364526300_nlaa132-B44","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.neuroscience.2007.06.060","article-title":"Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as \u201ccontinuum\u201d phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain","volume":"149","author":"Northington","year":"2007","journal-title":"Neuroscience"},{"key":"2024032523364526300_nlaa132-B45","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/dneu.22625","article-title":"Chromatolysis: Do injured axons regenerate poorly when ribonucleases attack rough endoplasmic reticulum, ribosomes and RNA?","volume":"78","author":"Moon","year":"2018","journal-title":"Dev Neurobiol"},{"key":"2024032523364526300_nlaa132-B46","doi-asserted-by":"crossref","first-page":"430","DOI":"10.6026\/97320630015430","article-title":"Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis","volume":"15","author":"Choudhury","year":"2019","journal-title":"Bioinformation"},{"key":"2024032523364526300_nlaa132-B47","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","article-title":"GFAP in health and disease","volume":"93","author":"Middeldorp","year":"2011","journal-title":"Prog Neurobiol"},{"key":"2024032523364526300_nlaa132-B48","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.clp.2019.08.002","article-title":"Anesthesia neurotoxicity in the developing brain: Basic studies relevant for neonatal or perinatal medicine","volume":"46","author":"Clausen","year":"2019","journal-title":"Clin Perinatol"},{"key":"2024032523364526300_nlaa132-B49","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1542\/peds.2005-0328","article-title":"Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy","volume":"116","author":"Rutherford","year":"2005","journal-title":"Pediatrics"},{"key":"2024032523364526300_nlaa132-B50","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3390\/cells9020478","article-title":"Extra virgin olive oil polyphenols: Modulation of cellular pathways related to oxidant species and inflammation in aging","volume":"9","author":"Serreli","year":"2020","journal-title":"Cells"},{"key":"2024032523364526300_nlaa132-B51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13760-020-01308-3","article-title":"Pathophysiology of hypoxic-ischemic encephalopathy: A review of the past and a view on the future","volume":"120","author":"Greco","year":"2020","journal-title":"Acta Neurol Belg"},{"key":"2024032523364526300_nlaa132-B52","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.phymed.2012.06.003","article-title":"The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model","volume":"19","author":"Rabiei","year":"2012","journal-title":"Phytomedicine"},{"key":"2024032523364526300_nlaa132-B53","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s11745-007-3097-6","article-title":"Dietary virgin olive oil reduces oxidative stress and cellular damage in rat brain slices subjected to hypoxia-reoxygenation","volume":"42","author":"Gonzalez-Correa","year":"2007","journal-title":"Lipids"},{"key":"2024032523364526300_nlaa132-B54","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fnins.2015.00138","article-title":"Classic and Golli Myelin Basic Protein have distinct developmental trajectories in human visual cortex","volume":"9","author":"Siu","year":"2015","journal-title":"Front Neurosci"},{"key":"2024032523364526300_nlaa132-B55","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1089\/brain.2019.0673","article-title":"Pig brains have homologous resting-state networks with human brains","volume":"9","author":"Simchick","year":"2019","journal-title":"Brain Connect"},{"key":"2024032523364526300_nlaa132-B56","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/CIRCULATIONAHA.111.048215","article-title":"White matter protection in congenital heart surgery","volume":"125","author":"Ishibashi","year":"2012","journal-title":"Circulation"},{"key":"2024032523364526300_nlaa132-B57","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1471-4159.1989.tb02516.x","article-title":"Developmental-study of myelin basic-protein variants in various regions of pig nervous-system","volume":"52","author":"Sheng","year":"1989","journal-title":"J Neurochem"},{"key":"2024032523364526300_nlaa132-B58","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mric.2011.08.009","article-title":"Advanced neonatal NeuroMRI","volume":"20","author":"Oishi","year":"2012","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"2024032523364526300_nlaa132-B59","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1523\/JNEUROSCI.12-12-04890.1992","article-title":"Myelin acquisition in the central nervous system of the mouse revealed by an MBP-Lac Z transgene","volume":"12","author":"Foran","year":"1992","journal-title":"J Neurosci"},{"key":"2024032523364526300_nlaa132-B60","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000112343","article-title":"Electroblot analysis of rat myelin proteolipid protein and basic protein during development","volume":"6","author":"Macklin","year":"1983","journal-title":"Dev Neurosci"},{"key":"2024032523364526300_nlaa132-B61","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41390-018-0138-1","article-title":"Early human brain development: Insights into macroscale connectome wiring","volume":"84","author":"Keunen","year":"2018","journal-title":"Pediatr Res"},{"key":"2024032523364526300_nlaa132-B62","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jpeds.2012.04.054","article-title":"White matter and cortical injury in hypoxic-ischemic encephalopathy: Antecedent factors and 2-year outcome","volume":"161","author":"Martinez-Biarge","year":"2012","journal-title":"J Pediatr"},{"key":"2024032523364526300_nlaa132-B63","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/pr.2013.132","article-title":"Cerebrovascular autoregulation and neurologic injury in neonatal hypoxic-ischemic encephalopathy","volume":"74","author":"Howlett","year":"2013","journal-title":"Pediatr Res"},{"key":"2024032523364526300_nlaa132-B64","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/jnen\/nlw025","article-title":"Human traumatic brain injury results in oligodendrocyte death and increases the number of oligodendrocyte progenitor cells","volume":"75","author":"Flygt","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523364526300_nlaa132-B65","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1203\/00006450-199811000-00018","article-title":"Lactate and pyruvate changes in the cerebral gray and white matter during posthypoxic seizures in newborn pigs","volume":"44","author":"Thoresen","year":"1998","journal-title":"Pediatr Res"},{"key":"2024032523364526300_nlaa132-B66","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41390-019-0475-8","article-title":"Protection of axonal integrity with 48 or 72 h of cerebral hypothermia in near-term fetal sheep","volume":"88","author":"Zhou","year":"2020","journal-title":"Pediatr Res"},{"key":"2024032523364526300_nlaa132-B67","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000369007","article-title":"Additive neuroprotection of a 20-HETE inhibitor with delayed therapeutic hypothermia after hypoxia-ischemia in neonatal piglets","volume":"37","author":"Zhu","year":"2015","journal-title":"Dev Neurosci"},{"key":"2024032523364526300_nlaa132-B68","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF00308474","article-title":"Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia","volume":"83","author":"Morioka","year":"1992","journal-title":"Acta Neuropathol"},{"key":"2024032523364526300_nlaa132-B69","doi-asserted-by":"crossref","first-page":"111921","DOI":"10.1016\/j.bbr.2019.111921","article-title":"Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition","volume":"369","author":"Singh","year":"2019","journal-title":"Behav Brain Res"},{"key":"2024032523364526300_nlaa132-B70","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1053\/j.semperi.2016.09.007","article-title":"Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE)","volume":"40","author":"Natarajan","year":"2016","journal-title":"Semin Perinatol"},{"key":"2024032523364526300_nlaa132-B71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/295215","article-title":"GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage","volume":"2014","author":"Gillani","year":"2014","journal-title":"Biomed Res Int"},{"key":"2024032523364526300_nlaa132-B72","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ejpn.2015.01.005","article-title":"Long-term motor and behavioral outcome after perinatal hypoxic-ischemic encephalopathy","volume":"19","author":"van Schie","year":"2015","journal-title":"Eur J Paediatr Neurol"},{"key":"2024032523364526300_nlaa132-B73","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neuropsychologia.2019.05.018","article-title":"Prefrontal neural dynamics in consciousness","volume":"131","author":"Leon-Dominguez","year":"2019","journal-title":"Neuropsychologia"},{"key":"2024032523364526300_nlaa132-B74","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/brain\/awu375","article-title":"Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination","volume":"138","author":"Wegener","year":"2015","journal-title":"Brain"},{"key":"2024032523364526300_nlaa132-B75","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.mcn.2006.08.007","article-title":"Induced expression of Olig2 is sufficient for oligodendrocyte specification but not for motoneuron specification and astrocyte repression","volume":"33","author":"Du","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"2024032523364526300_nlaa132-B76","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nrn3386","article-title":"Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2","volume":"13","author":"Meijer","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"2024032523364526300_nlaa132-B77","first-page":"71","article-title":"Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair","volume":"4","author":"Domingues","year":"2016","journal-title":"Front Cell Dev Biol"},{"key":"2024032523364526300_nlaa132-B78","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1213\/ANE.0b013e31824762d5","article-title":"Noninvasive autoregulation monitoring in a swine model of pediatric cardiac arrest","volume":"114","author":"Lee","year":"2012","journal-title":"Anesth Analg"},{"key":"2024032523364526300_nlaa132-B79","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-cellbio-100818-125204","article-title":"Developmental cell death in the cerebral cortex","volume":"35","author":"Wong","year":"2019","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2024032523364526300_nlaa132-B80","doi-asserted-by":"crossref","first-page":"10142","DOI":"10.1038\/s41598-019-46505-0","article-title":"Differential effects of slow rewarming after cerebral hypothermia on white matter recovery after global cerebral ischemia in near-term fetal sheep","volume":"9","author":"Draghi","year":"2019","journal-title":"Sci Rep"},{"key":"2024032523364526300_nlaa132-B81","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/pr.2012.138","article-title":"Effects of combination therapy using hypothermia and erythropoietin in a rat model of neonatal hypoxia-ischemia","volume":"73","author":"Fang","year":"2013","journal-title":"Pediatr Res"},{"key":"2024032523364526300_nlaa132-B82","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/pr.2015.100","article-title":"Therapeutic hypothermia and hypoxia-ischemia in the term-equivalent neonatal rat: Characterization of a translational preclinical model","volume":"78","author":"Patel","year":"2015","journal-title":"Pediatr Res"},{"key":"2024032523364526300_nlaa132-B83","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.thromres.2004.06.038","article-title":"Growth and function of the normal human placenta","volume":"114","author":"Gude","year":"2004","journal-title":"Thromb Res"},{"key":"2024032523364526300_nlaa132-B84","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/s41390-019-0493-6","article-title":"Placental pathology and neonatal brain MRI in a randomized trial of erythropoietin for hypoxic-ischemic encephalopathy","volume":"87","author":"Wu","year":"2020","journal-title":"Pediatr Res"},{"key":"2024032523364526300_nlaa132-B85","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000490349","article-title":"The glymphatic system and waste clearance with brain aging: A review","volume":"65","author":"Benveniste","year":"2019","journal-title":"Gerontology"},{"key":"2024032523364526300_nlaa132-B86","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1213\/ANE.0000000000004069","article-title":"Glymphatic system function in relation to anesthesia and sleep states","volume":"128","author":"Benveniste","year":"2019","journal-title":"Anesth Analg"},{"key":"2024032523364526300_nlaa132-B87","doi-asserted-by":"crossref","first-page":"F346","DOI":"10.1136\/archdischild-2015-309639","article-title":"Management and investigation of neonatal encephalopathy: 2017 update","volume":"102","author":"Martinello","year":"2017","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2024032523364526300_nlaa132-B88","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/BF00687789","article-title":"The nature and timing of excitotoxic neuronal necrosis in the cerebral cortex, hippocampus and thalamus due to flurothyl-induced status epilepticus","volume":"75","author":"Ingvar","year":"1988","journal-title":"Acta Neuropathol"},{"key":"2024032523364526300_nlaa132-B89","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF01182228","article-title":"Comparative electron microscopic and autoradiographic studies of \u201cdark\u201d and \u201clight\u201d neurons of the cerebral cortex","volume":"10","author":"Rubleva","year":"1980","journal-title":"Neurosci Behav Physiol"},{"key":"2024032523364526300_nlaa132-B90","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/jmri.27181","article-title":"Mean diffusivity in striatum correlates with acute neuronal death but not lesser neuronal injury in a pilot study of neonatal piglets with encephalopathy","volume":"52","author":"Lee","year":"2020","journal-title":"J Magn Reson Imaging"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/80\/2\/182\/35933266\/nlaa132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/80\/2\/182\/35933266\/nlaa132.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T23:57:24Z","timestamp":1711411044000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/80\/2\/182\/5992385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":90,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,11,19]]},"published-print":{"date-parts":[[2021,1,20]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlaa132","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2,1]]},"published":{"date-parts":[[2020,11,19]]}}}