{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:44:03Z","timestamp":1792651443250,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100008908","name":"University of Messina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Posterior pituitary tumors are supposed to represent the morphological spectrum of a single entity. Herein, we report the clinical-pathological, immunohistochemical, and genetic features of 5 spindle cell oncocytomas (SCOs), 3 pituicytomas, and 1 granular cell tumor (GCT). SCOs had the highest local invasiveness and affected older subjects. The 3 histotypes differed in the content of spindle cells (predominant in pituicytoma and absent in GCT), presence of lymphocytic infiltrate (in SCO and GCT, but not in the pituicytoma) and EMA\/GFAP staining (negative in GCT; EMA-positive\/GFAP-negative in 4\/5 SCO and GFAP-positive in 3\/3 pituicytomas). Three SCOs and 1 pituicytoma analyzed with next-generation sequencing had no mutations in 409 genes. However, 1 SCO had previously unreported homozygous deletion of CDKN2A\/B and another of SMARCA4, SMARCB1, and NF2. All 3 SCOs had loss of heterozygosity of chromosome 1p, while the pituicytoma had chromosome 19 homozygous loss and chromosomes 10, 13q, and 18q loss of heterozygosity. Since 1p and 13q losses were previously reported in 1 pituicytoma and 1 SCO, respectively, our data demonstrate that posterior pituitary tumors share common genetic alterations. The possibility that posterior pituitary tumors are SMARCA4\/SMARCB1-deficient should be kept in mind in the differential diagnosis toward other entities.<\/jats:p>","DOI":"10.1093\/jnen\/nlaa139","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T23:48:55Z","timestamp":1605916135000},"page":"45-51","source":"Crossref","is-referenced-by-count":10,"title":["Clinical-Pathological, Immunohistochemical, and Genetic Characterization of a Series of Posterior Pituitary Tumors"],"prefix":"10.1093","volume":"80","author":[{"given":"Valeria","family":"Barresi","sequence":"first","affiliation":[{"name":"From the Department of Diagnostics and Public Health, Section of Anatomic Pathology, University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Simbolo","sequence":"additional","affiliation":[{"name":"From the Department of Diagnostics and Public Health, Section of Anatomic Pathology, University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gessi","sequence":"additional","affiliation":[{"name":"Neuropathology Unit, Division of Pathology, Fondazione Policlinico Universitario \u201cA.Gemelli\u201d IRCCS, Catholic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Rossi","sequence":"additional","affiliation":[{"name":"Unit of Pathology, Bambino Ges\u00f9 Hospital (SR) , Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Caffo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Neurosurgery, University of Messina , Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albino","family":"Eccher","sequence":"additional","affiliation":[{"name":"Unit of Anatomic Pathology, Department of Pathology and Diagnostics, Hospital Trust of Verona , Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo Flavio","family":"Angileri","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Neurosurgery, University of Messina , Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cannav\u00f2","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Childhood and Adulthood, University of Messina , Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Brunelli","sequence":"additional","affiliation":[{"name":"From the Department of Diagnostics and Public Health, Section of Anatomic Pathology, University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Scarpa","sequence":"additional","affiliation":[{"name":"ARC-Net Research Centre, University and Hospital Trust of Verona , Verona (AS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"2024032523363594400_nlaa139-B1","volume-title":"WHO Classification of Tumors of Endocrine Organs","year":"2017"},{"key":"2024032523363594400_nlaa139-B2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/archneurpsyc.1958.02340110037005","article-title":"Pituicytoma, a tumor of the hypothalamus; clinicopathological report of a case","volume":"80","author":"Liss","year":"1958","journal-title":"AMA Arch Neurpsych"},{"key":"2024032523363594400_nlaa139-B3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3171\/jns.1958.15.5.0481","article-title":"Pituicytoma, tumor of the sella turcica; A clinicopathological study","volume":"15","author":"Liss","year":"1958","journal-title":"J Neurosurg"},{"key":"2024032523363594400_nlaa139-B4","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1097\/00000478-200208000-00010","article-title":"Spindle cell oncocytoma' of the adenohypophysis: A tumor of folliculostellate cells?","volume":"26","author":"Roncaroli","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"2024032523363594400_nlaa139-B5","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.3174\/ajnr.A2717","article-title":"Pituicytoma, spindle cell oncocytoma, and granular cell tumor: Clarification and meta-analysis of the world literature since 1893","volume":"32","author":"Covington","year":"2011","journal-title":"AJNR Am J Neuroradiol"},{"key":"2024032523363594400_nlaa139-B6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00401-002-0557-1","article-title":"Pituicytomas, a mis-diagnosed benign tumor of the neurohypophysis: Report of three cases","volume":"104","author":"Figarella-Branger","year":"2002","journal-title":"Acta Neuropathol"},{"key":"2024032523363594400_nlaa139-B7","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/NEN.0b013e3181a13fca","article-title":"Thyroid transcription factor 1 expression in sellar tumors: A histogenetic marker?","volume":"68","author":"Lee","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523363594400_nlaa139-B8","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1097\/PAS.0b013e31829723e7","article-title":"Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma","volume":"37","author":"Mete","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"2024032523363594400_nlaa139-B9","first-page":"52","volume-title":"WHO Classification of Tumors of Endocrine Organs","author":"Mete","year":"2017"},{"key":"2024032523363594400_nlaa139-B10","volume-title":"WHO Classification of Tumors of the Central Nervous System","author":"Luois","year":"2016"},{"key":"2024032523363594400_nlaa139-B11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/bpa.12068","article-title":"Update on hypophysitis and TTF-1 expressing sellar region masses","volume":"23","author":"Kleinschmidt-DeMasters","year":"2013","journal-title":"Brain Pathol"},{"key":"2024032523363594400_nlaa139-B12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jocn.2017.02.017","article-title":"Spindle cell oncocytoma: report of two cases with massive bleeding and review of the literature","volume":"39","author":"Billeci","year":"2017","journal-title":"J Clin Neurosci"},{"key":"2024032523363594400_nlaa139-B13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s40618-018-0923-z","article-title":"Clinical features, diagnosis and therapy of pituicytoma: An update","volume":"42","author":"Salge-Arrieta","year":"2019","journal-title":"J Endocrinol Invest"},{"key":"2024032523363594400_nlaa139-B14","doi-asserted-by":"crossref","first-page":"894","DOI":"10.12659\/AJCR.903702","article-title":"Spindle Cell oncocytoma of the anterior pituitary presenting with an acute clinical course due to intraventricular hemorrhage. 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